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Cornus officinalis contains bioactive iridoid glycosides, including cornuside, loganic acid, and loganin, along with ursolic acid. These compounds exert antioxidant and anti-inflammatory effects that support kidney and liver function. In Traditional Chinese Medicine theory, the fruit acts as an astringent tonic that stabilizes the kidney and liver, preventing abnormal leakage of essence and fluids. The herb's adaptogenic properties may relate to modulation of the hypothalamic-pituitary-adrenal axis, though human mechanistic studies remain limited. Evidence level: C.
Does Cornus fruit interact with any medications?
No significant drug interactions have been documented for Cornus officinalis in the scientific literature. However, due to its astringent properties and traditional effects on kidney function, theoretical interactions with diuretics or medications affecting renal function cannot be ruled out. The tannin content may potentially reduce absorption of certain drugs if taken simultaneously. Patients on prescription medications should consult a qualified healthcare provider before adding Cornus fruit supplements to their regimen. Evidence level: Traditional.
What is the recommended dosage for Cornus officinalis?
The standard adult dosage for Cornus officinalis is 6-12 grams of dried fruit prepared as a decoction daily, or 500-1000mg of standardized extract. In Traditional Chinese Medicine practice, the fruit is typically combined with other herbs in formulations such as Liu Wei Di Huang Wan, where it serves as a key stabilizing ingredient. Dosage should be adjusted based on individual constitution and the specific condition being treated. Consult a qualified herbalist for personalized dosing recommendations. Evidence level: Traditional.
Is Cornus fruit safe to take during pregnancy?
Cornus officinalis is generally considered safe during pregnancy when used at recommended doses under professional guidance. In Traditional Chinese Medicine, the fruit has been used as a kidney tonic to support essence, which is believed important during pregnancy. However, clinical safety data specific to pregnancy is limited. Pregnant women should always consult a qualified healthcare provider before using any herbal supplements to ensure appropriate use for their individual circumstances. Evidence level: Traditional.
What are the side effects and contraindications of Cornus officinalis?
Cornus officinalis is generally well-tolerated, with mild gastrointestinal upset being the most commonly reported side effect. The herb is contraindicated in Traditional Chinese Medicine for individuals with damp heat conditions or difficult, painful urination. These contraindications relate to the herb's astringent nature, which may worsen conditions where fluids need to flow freely rather than be constrained. Those with urinary obstruction or strong heat signs should avoid this herb unless prescribed by a qualified practitioner. Evidence level: Traditional.
What is Cornus officinalis used for in Traditional Chinese Medicine?
Cornus officinalis, known as Shan Zhu Yu in Chinese medicine, is used to stabilize the kidney and liver, stop excessive sweating, and prevent leakage of essence. It is commonly prescribed for urinary frequency, impotence, spermatorrhea, and spontaneous sweating. As a key ingredient in the foundational formula Liu Wei Di Huang Wan, it helps anchor and stabilize while supporting overall vitality. Modern applications also classify it as an adaptogenic herb for supporting stress response. Evidence level: C.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Cornus officinalis is a traditional East Asian medicinal herb used for kidney-tonifying and anti-inflammatory purposes [PMID:40784528, PMID:33912050]. Recent research highlights its potential in treating neurodegenerative, metabolic, and renal disorders [PMID:33912050, PMID:40714074].
Contexte
Cornus officinalis (Asiatic dogwood) is a deciduous tree distributed in eastern Asia, primarily China, Korea, and Japan [PMID:30210335]. Its ripening and dry fruits, known as Corni Fructus, are essential components of Traditional Chinese Medicine (TCM) [PMID:29983732].
Usages traditionnels
Traditionally used for nearly two thousand years in TCM to treat dizziness, tinnitus, impotence, spermatorrhea, profuse sweating, and conditions affecting the lumbar and knee regions [PMID:40784528, PMID:29155174]. It is characterized by sour, astringent, and warming properties used to tonify the liver and kidney and nourish the essence [PMID:33912050, PMID:40784528].
Composés actifs
Identified bioactive constituents include iridoids (loganin, morroniside, sweroside, cornuside, cornuside I, cornel iridoid glycoside), flavonoids (kaempferol, myricetin, quercetin, trifolin), and verbenalin [PMID:38111697, PMID:39307743, PMID:36628351, PMID:36104266].
Mécanisme d'action
Mechanisms include attenuation of the NLRP3 inflammasome axis [PMID:39972387, PMID:40490233, PMID:39510640], promotion of mitophagy via Pink1/Parkin signaling [PMID:39972387], activation of the NRF2/HO-1 pathway [PMID:39510640], and regulation of the PI3K/AKT pathway [PMID:40490233, PMID:40432887]. It also modulates gut microbiota to suppress proinflammatory metabolites [PMID:40501499, PMID:38788396].
Preuves cliniques
Preuve DCognitive Impairment/Alzheimer's
Cornuside ameliorated behavioral deficits and protected synaptic plasticity by attenuating NLRP3-mediated neurotoxicity and promoting mitophagy in mice [PMID:39972387].
Preuve DAcute Lung Injury (ALI)
Cornus officinalis ethanol extract and loganin attenuated ALI in mice by regulating the PI3K/AKT/NLRP3 axis [PMID:40490233].
Preuve COsteoporosis
Bioactive constituents like morroniside and sweroside are supported as effective in OP treatment [PMID:38111697].
Preuve CDiabetes and Complications
Loganin and morroniside promote insulin secretion and improve insulin resistance; they show potential in treating diabetic nephropathy and neuropathy [PMID:40714074].
Preuve DHyperuricemia
Extracts significantly reduced serum uric acid levels and increased urinary excretion by modulating URAT1 in rat models [PMID:41155274].
Preuve DNon-alcoholic Steatohepatitis (NASH)
Sécurité et effets indésirables
Verbenalin, a compound in C. officinalis, showed no signs of mutagenicity in the Ames test [PMID:36628351]. Some reviews note low toxicity and excellent tolerability for long-term administration [PMID:38111697].
Synthèse des preuves
The evidence is primarily based on in vitro studies and animal models (Level D), with several comprehensive reviews (Level C) summarizing traditional use and phytochemical profiles. There is a lack of high-level human clinical trial data (Level A/B) in the provided abstracts.
Sources PubMed
1.PMID: 39972387 (2025) — Cornuside alleviates cognitive impairments induced by Aβ1-42 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy. · Alzheimer's research & therapy
3.PMID: 30210335 (2018) — Cornus mas and Cornus Officinalis-Analogies and Differences of Two Medicinal Plants Traditionally Used. · Frontiers in pharmacology
4.PMID: 40490233 (2025) — Cornus officinalis loganin attenuates acute lung injury in mice via regulating the PI3K/AKT/NLRP3 axis. · Journal of ethnopharmacology
5.PMID: 38111697 (2023) — Cornus officinalis: a potential herb for treatment of osteoporosis. · Frontiers in medicine
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Morroniside delayed NASH progression by promoting AMPK-mediated lipophagy in mice [PMID:38723527].
Preuve DPost-stroke Depression
Morroniside alleviated depression-like behaviors in mice via the BDNF signaling pathway [PMID:38006805].
6.PMID: 36628351 (2022) — Bacterial Reverse Mutation Test of Verbenalin. · Journal of pharmacopuncture
7.PMID: 39307743 (2024) — [A new secoiridoid from Cornus officinalis]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
8.PMID: 40784528 (2025) — Cornus officinalis Sieb.: An updated review on the ethnopharmacology, phytochemistry, pharmacology, toxicology, and pharmacokinetics. · Journal of ethnopharmacology
9.PMID: 39510640 (2024) — Loganin inhibits the ROS-NLRP3-IL-1β axis by activating the NRF2/HO-1 pathway against osteoarthritis. · Chinese journal of natural medicines
10.PMID: 33912050 (2021) — Active Components and Pharmacological Effects of Cornus officinalis: Literature Review. · Frontiers in pharmacology
11.PMID: 37579922 (2024) — Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple ameliorates renal interstitial fibrosis in CKD rats by inhibiting the TGF-β1/MAPK signaling pathway. · Journal of ethnopharmacology
12.PMID: 38723527 (2024) — Morroniside delays the progression of non-alcoholic steatohepatitis by promoting AMPK-mediated lipophagy. · Phytomedicine : international journal of phytotherapy and phytopharmacology
13.PMID: 29983732 (2018) — Corni Fructus: a review of chemical constituents and pharmacological activities. · Chinese medicine
14.PMID: 29155174 (2018) — Ethnopharmacology, phytochemistry, and pharmacology of Cornus officinalis Sieb. et Zucc. · Journal of ethnopharmacology
15.PMID: 37475719 (2023) — Research progress on Cornus officinalis and its active compounds in the treatment of diabetic nephropathy. · Frontiers in pharmacology
16.PMID: 40661830 (2025) — Cornus officinalis Protects Against Steroid-Induced Osteonecrosis of the Femoral Head Through Inhibiting Inflammatory Responses and Apoptosis via Network Pharmacology and Experimental Validation. · Drug design, development and therapy
17.PMID: 38788396 (2024) — Therapeutic mechanism of Cornus Officinalis Fruit Coreon on ALI by AKT/Nrf2 pathway and gut microbiota. · Phytomedicine : international journal of phytotherapy and phytopharmacology
18.PMID: 41403435 (2025) — Decoding the therapeutic potential mechanism of Cornus officinalis in Parkinson's disease: a network pharmacology insight. · Frontiers in pharmacology
19.PMID: 40714074 (2025) — Loganin and morroniside: Therapeutic effects and molecular mechanisms in diabetes mellitus and its complications-A review. · European journal of pharmacology
20.PMID: 40501499 (2025) — Cornus officinalis Extract Ameliorates Fructose-Induced Hepatic Steatosis in Mice by Sustaining the Homeostasis of Intestinal Microecology and Lipid Metabolism. · Food science & nutrition
21.PMID: 41663651 (2026) — Cornus officinalis extract modulates rumen microbiome and growth of lambs fed a high-concentrate diet. · AMB Express
22.PMID: 40962125 (2026) — Cornuside ameliorates LPS induced cognitive dysfunction and microglial NLRP3 inflammasome activation by enhancing Sirt1-mediated autophagy. · Journal of ethnopharmacology
24.PMID: 36104266 (2022) — Cornel Iridoid Glycoside Alleviates Microglia-Mediated Inflammatory Response via the NLRP3/Calpain Pathway. · Journal of agricultural and food chemistry
25.PMID: 41155274 (2025) — Antihyperuricemic Effects of Cornus officinalis Extract via URAT1 Regulation and Renoprotective Mechanisms. · International journal of molecular sciences
26.PMID: 35592634 (2022) — Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity. · Frontiers in nutrition
27.PMID: 42178074 (2026) — Combination of Cornus officinalis Siebold and Moutan officinalis (L.) Lindl. alleviates the metabolic disorders of MAFLD through regulating IRE1α/ASK1/JNK pathway mediated endoplasmic reticulum stress. · Journal of ethnopharmacology
28.PMID: 40432887 (2025) — Regulation of autophagy by the PI3K-AKT pathway in Astragalus membranaceus -Cornus officinalis to ameliorate diabetic nephropathy. · Frontiers in pharmacology
29.PMID: 33930987 (2022) — Secoiridoid glycosides from the fruits of Cornus officinalis. · Natural product research
30.PMID: 38006805 (2024) — Morroniside improves the symptoms of post-stroke depression in mice through the BDNF signaling pathway mediated by MiR-409-3p. · Phytomedicine : international journal of phytotherapy and phytopharmacology