How does Costmary work as a digestive aid?

Costmary acts primarily as a carminative and bitter tonic. Its active compounds, particularly carvone and camphor, help relax smooth muscle in the gastrointestinal tract to relieve spasms and expel gas. The herb's flavonoids may also contribute to anti-inflammatory effects. While these mechanisms are well-understood pharmacologically, clinical evidence specifically for Costmary is limited (Evidence Level C), relying largely on traditional use and constituent analysis rather than randomized controlled trials.

Is Costmary safe to take during pregnancy?

No, Costmary is considered unsafe during pregnancy and breastfeeding. The herb contains thujone and camphor, compounds known to stimulate uterine contractions and potentially cause miscarriage or fetal harm. Thujone is a neurotoxin that can cross the placenta. Because of these risks, pregnant women should strictly avoid Costmary supplements, teas, or essential oils (Evidence Level D/Traditional safety rating).

What is the recommended dosage for Costmary tea?

The standard adult dosage for Costmary is 1 to 3 grams of dried herb daily, prepared as an infusion or tea. To prepare, steep the dried herb in boiling water for 5 to 10 minutes. It is crucial not to exceed this recommended amount due to the potential for thujone toxicity. Dosage recommendations are based on traditional use and pharmacopoeia standards (Evidence Level C), as clinical trials establishing an optimal dose are lacking.

Does Costmary interact with any medications?

Costmary may interact with medications metabolized by the liver due to its camphor and flavonoid content. Because it contains thujone, it should be avoided by individuals taking anticonvulsants, as thujone can lower the seizure threshold. Additionally, Costmary may potentiate the effects of sedatives or anticoagulants. There is limited clinical data on specific drug interactions (Evidence Level C), so patients should consult a physician before combining it with prescription medications.

What are the side effects of Costmary?

When consumed in moderate amounts, Costmary is generally well-tolerated for digestive complaints. However, excessive intake can lead to thujone toxicity, resulting in symptoms such as dizziness, nausea, vomiting, headaches, and in severe cases, seizures or kidney damage. Long-term use is discouraged due to thujone accumulation. Individuals with liver or kidney disorders should exercise caution, as these organs are responsible for processing the herb's active compounds (Evidence Level C).

Costmary (Tanacetum balsamita)

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 27 articles PubMed · modèle : gemma4:31b

Résumé

Tanacetum balsamita L. (costmary) is an Asteraceae species used traditionally as a tonic, carminative, and aromatic plant [PMID:36616151].

Contexte

Costmary (Tanacetum balsamita L.) is a medicinal plant characterized by various chemotypes, including 'camphor' and 'carvone' types, depending on its cultivation and origin [PMID:40805755, PMID:36559586].

Usages traditionnels

It is traditionally used as an aromatic, carminative, and tonic plant [PMID:36616151], and in Transylvanian ethnobotany for the treatment of wounds, furuncles, and liver disorders [PMID:38931084]. It has also been used in human medicine to address gastrointestinal problems such as abdominal pain [PMID:35601771].

Composés actifs

The plant contains over 100 secondary metabolites, including acylquinic acids, flavonoid glycosides, phenolic acids, and sesquiterpene lactones [PMID:36616151, PMID:34791965]. Key components of its essential oils include carvone, alpha-thujone, beta-thujone, camphor, and camphene [PMID:34961198, PMID:19370888, PMID:10888559]. Parthenolide is identified as a main active ingredient extracted from the buds [PMID:41262674].

Mécanisme d'action

Parthenolide acts as a nuclear factor-kappaB (NF-kappaB) inhibitor [PMID:36307537] and promotes diabetic wound healing by targeting TNF-alpha and STAT3 pathways [PMID:42337164]. Extracts have shown inhibition of acetyl- and butyrylcholinesterase [PMID:36616151] and 5-lipoxygenase and alpha-glucosidase enzymes [PMID:34791965].

Preuves cliniques

Preuve DMetabolic-associated fatty liver disease (MAFLD)

Methanol-aqueous extract (150-300 mg/kg bw) in rats significantly reduced blood glucose (by ~20%), lipase activity (by 52%), total cholesterol (by 50%), and triglycerides (by 57%) [PMID:39124206].

Preuve DMetabolic-induced renal injury (MIRI)

Leaf extract (150-300 mg/kg) in diabetic rats decreased blood glucose, lowered systolic pressure, reduced urea and creatinine levels, and alleviated proteinuria [PMID:40699692].

Preuve DDoxorubicin-induced cardiotoxicity

Parthenolide inhibited cytotoxicity and cardiomyocyte apoptosis in H9c2 cells and C57BL/6J mice [PMID:41262674].

Preuve DPeritoneal fibrosis

Parthenolide improved peritoneal fibrosis in PD mice by selectively inhibiting the phosphorylation of Smad2/3 [PMID:36307537].

Preuve DDiabetic wounds

Parthenolide (100 uM and 200 uM) significantly accelerated wound repair in diabetic mouse models by enhancing keratinocyte proliferation and angiogenesis [PMID:42337164].

Preuve D

Sécurité et effets indésirables

A methanol-aqueous extract was found to be non-toxic with an LD50 > 3000 mg/kg in rat models [PMID:39124206].

Synthèse des preuves

The current evidence is based on in vitro studies and animal models (rats, mice, fish), indicating potential anti-inflammatory, antioxidant, and metabolic benefits. There are no human clinical trials provided.

Sources PubMed

1.PMID: 36616151 (2022) — An In-Depth Study of Metabolite Profile and Biological Potential of Tanacetum balsamita L. (Costmary). · Plants (Basel, Switzerland)
2.PMID: 40805755 (2025) — Sustainable Agronomical Practices Affect Essential Oil Composition of Tanacetum balsamita L. · Plants (Basel, Switzerland)
3.PMID: 34961198 (2021) — Allelopathic Effects of Essential Oils on Seed Germination of Barley and Wheat. · Plants (Basel, Switzerland)
4.PMID: 36616147 (2022) — Antiviral Activity of Selected Essential Oils against Cucumber Mosaic Virus. · Plants (Basel, Switzerland)
5.PMID: 34791965 (2023) — A new eudesmanolide from Tanacetum balsamita L. and biological activities of extracts.

Costmary

Sources et citations

Scoparia Dulcis

Osmorhiza longistylis

Mentha longifolia

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Costmary

Sources et citations

Plantes associées

Scoparia Dulcis

Osmorhiza longistylis

Mentha longifolia

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales