Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Costus speciosus contains steroidal saponins, particularly diosgenin and dioscin, which appear to enhance insulin sensitivity and support glucose metabolism. The plant also contains flavonoids like kaempferol and quercetin, which have demonstrated antioxidant properties that may protect pancreatic beta cells from oxidative damage. Research suggests these compounds may help improve glucose uptake in peripheral tissues, though the exact mechanism requires further study. Evidence level: C (preliminary clinical evidence).
Can Costus speciosus interact with diabetes medications?
Yes, Costus speciosus may interact with hypoglycemic medications. Because this herb has blood sugar-lowering properties, combining it with prescription diabetes medications like metformin, insulin, or sulfonylureas may cause additive effects, potentially leading to dangerously low blood glucose levels (hypoglycemia). If you are taking diabetes medications, consult your healthcare provider before using Costus speciosus. Close monitoring of blood glucose levels would be essential if combined use is medically supervised.
What is the recommended dosage for Costus speciosus?
The typical adult dosage for Costus speciosus is 3-6 grams of leaf powder or dried leaf tea daily. This can be divided into two or three doses throughout the day. For blood sugar management, it is best taken with meals to reduce the risk of gastrointestinal upset. Always start with the lower end of the dosage range to assess individual tolerance. Standardized preparations may offer different dosing guidelines, so follow product-specific recommendations when available.
Is Costus speciosus safe during pregnancy?
No, Costus speciosus is not considered safe during pregnancy. The herb contains steroidal compounds, including diosgenin, which may have hormonal effects and could potentially stimulate uterine contractions or affect fetal development. Traditional use and available evidence contraindicate its use in pregnant women. Women who are pregnant, trying to conceive, or breastfeeding should avoid Costus speciosus. Consult a qualified healthcare provider for appropriate alternatives during pregnancy.
What are the medicinal uses of Costus speciosus?
Costus speciosus is traditionally used for several health conditions, with its primary modern application being blood sugar management in diabetes. Other traditional uses include treating rheumatism, reducing fever, relieving constipation, and addressing respiratory conditions like bronchitis. The plant's active compounds—diosgenin, dioscin, gracillin, and various flavonoids—contribute to its anti-inflammatory and potential metabolic effects. Evidence level: C (preliminary clinical evidence) for diabetes; other uses are primarily based on traditional practice.
What are the side effects of Costus speciosus?
The most common side effects of Costus speciosus include hypoglycemia (low blood sugar) and gastrointestinal upset, such as nausea, bloating, or diarrhea. Hypoglycemia is more likely when the herb is taken in high doses or combined with other blood sugar-lowering agents. Symptoms of low blood sugar may include dizziness, sweating, confusion, and weakness. Discontinue use if severe symptoms occur and seek medical attention. Those with existing hypoglycemia or on diabetes medications should use this herb only under professional supervision.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Costus speciosus, also known as crepe ginger, is a medicinal plant native to Southeast Asia used in traditional medicine for various inflammatory and metabolic conditions [PMID:27515456, PMID:26593213].
Contexte
Costus speciosus (Koen ex. Retz.) Sm. is an ornamental plant from the Costaceae family native to Southeast Asia, specifically found in India, Sri Lanka, Indonesia, and Malaysia [PMID:27515456, PMID:26593213].
Usages traditionnels
It is used in traditional medicine to treat inflammation, rheumatism, bronchitis, fever, headache, asthma, flatulence, constipation, helminthiasis, leprosy, skin diseases, hiccough, anemia, burning sensation on urination [PMID:26593213], and 'khadar' or paresthesia in Islamic Traditional Medicine [PMID:26561077]. It also has a long history in Indian Ayurvedic medicine [PMID:40435094].
Composés actifs
Bioactive ingredients include alkaloids, flavonoids, glycosides, phenols, saponins, sterols, sesquiterpenes [PMID:27515456], diosgenin [PMID:34581038], raffinose [PMID:29458019], and 22-ketocholesteryl palmitate [PMID:28480734]. Metabolic profiling of rhizomes also identified methyl protogracillin, dioscin, caffeic acid, and trehalose [PMID:28814124].
Mécanisme d'action
Anticancer activity is attributed to the up-regulation of apoptotic molecules (p53, p21, p27, caspases, ROS) and down-regulation of anti-apoptotic agents (Akt, Bcl2, NFKB, STAT3, JAK, MMPs, actin, surviving, vimentin) [PMID:27515456]. Raffinose modulates PPARs/SREBP1c to attenuate lipid synthesis and improves insulin sensitivity via the IRβ/PI3K/Akt pathway [PMID:29458019].
Preuves cliniques
Preuve CCancer
Bioactive compounds exhibit cytotoxic effects against breast, ovarian, and uterine cancers by inducing apoptosis and regulating the cell cycle [PMID:40435094].
Preuve DInflammation
Sesquiterpenes from rhizomes demonstrate anti-inflammatory activity by affecting levels of IL-6, IL-1β, TNF-α, and COX-2 [PMID:26593213].
Preuve DPolycystic Ovary Syndrome (PCOS)
In female rats, extract ameliorated phenotypes of letrozole-induced PCOS [PMID:41983838].
Preuve DDiabetes-induced Prostate Changes
Gold nanoparticles of C. speciosus ameliorated structural changes in the prostate of diabetic rats by mediating pro-inflammatory cytokines IL-6, IL-1β, and TNF-α [PMID:35164292].
Preuve DOxidative Damage (Zearalenone)
Extract protected rats against zearalenone-induced oxidative damage, genotoxicity, and cytotoxicity via modulation of Nrf2 and iNOS [PMID:35597521].
Preuve DUterine Contractility
Sécurité et effets indésirables
General risks associated with herbal products include potential contamination with heavy metals or toxic chemicals, which can lead to acute hepatic or renal failure [PMID:28152355]. Specific safety data for C. speciosus is limited, and further research is required to ensure the safety of its extracts [PMID:40435094].
Synthèse des preuves
The evidence consists primarily of in vitro studies, animal models (rats/mice), and review articles. There are no human clinical trials provided in the abstracts.
Sources PubMed
1.PMID: 27515456 (2016) — Possible Anticancer Mechanisms of Some Costus speciosus Active Ingredients Concerning Drug Discovery. · Current drug discovery technologies
2.PMID: 34581038 (2021) — [Research on anti-tumor natural product diosgenin]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
3.PMID: 26593213 (2015) — Anti-inflammatory sesquiterpenes from Costus speciosus rhizomes. · Journal of ethnopharmacology
4.PMID: 40435094 (2025) — Exploring the anticancer potential of Costus speciosus: a comprehensive review. · Brazilian journal of biology = Revista brasleira de biologia
5.PMID: 28152355 (2017) — What risks do herbal products pose to the Australian community? · The Medical journal of Australia
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Ethanolic rhizome extract increased spontaneous phasic contractions in rat myometrium, an effect abolished by L-type calcium channel or MLCK inhibition [PMID:21566246].
6.PMID: 21566246 (2011) — The effects of wild ginger (Costus speciosus (Koen) Smith) rhizome extract and diosgenin on rat uterine contractions. · Reproductive sciences (Thousand Oaks, Calif.)
7.PMID: 35597521 (2022) — Costus speciosus extract protects against the oxidative damage of zearalenone via modulation of inflammatory cytokines, Nrf2 and iNOS gene expression in rats. · Toxicon : official journal of the International Society on Toxinology
8.PMID: 35164292 (2022) — Nanoparticles of Costus speciosus Ameliorate Diabetes-Induced Structural Changes in Rat Prostate through Mediating the Pro-Inflammatory Cytokines IL 6, IL1β and TNF-α. · Molecules (Basel, Switzerland)
9.PMID: 28814124 (2018) — Comparative metabolic profiling of Costus speciosus leaves and rhizomes using NMR, GC-MS and UPLC/ESI-MS/MS. · Natural product research
10.PMID: 41983838 (2026) — The fortunate amelioration of Costus speciosus on phenotypes of letrozole-induced polycystic ovary syndrome in female rats. · Brazilian journal of biology = Revista brasleira de biologia
11.PMID: 29458019 (2018) — Raffinose from Costus speciosus attenuates lipid synthesis through modulation of PPARs/SREBP1c and improves insulin sensitivity through PI3K/AKT. · Chemico-biological interactions
12.PMID: 26561077 (2016) — Paresthesia: A Review of Its Definition, Etiology and Treatments in View of the Traditional Medicine. · Current pharmaceutical design
13.PMID: 28480734 (2018) — A new oxo-sterol derivative from the rhizomes of Costus speciosus. · Natural product research