Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
PubMed · Cyclopia maculata and Cyclopia subternata (honeybush tea) inhibits adipogenesis in 3T3-L1 pre-adipocytes. (2013)
PubMed · Analysis of the Differentially Expressed Proteins and Metabolic Pathways of Honeybush (<i>Cyclopia subternata</i>) in Response to Water Deficit Stress. (2023)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Cyclopia subternata is a South African shrub used to produce honeybush tea, recognized for its rich polyphenol content and antioxidant properties [PMID:15315375, PMID:37299160].
Contexte
Cyclopia subternata is one of several endemic South African shrub species used to brew honeybush tea [PMID:15315375, PMID:35033263]. It is characterized by a pleasant flavor, low tannin content, and the absence of caffeine [PMID:15315375, PMID:19032980].
Usages traditionnels
Since the 19th century, honeybush tea has been consumed to treat various medical ailments [PMID:23428403]. It has been used as a tonic for colds, influenza, catarrh, and pulmonic tuberculosis, and is noted for alleviating menopausal symptoms in women [PMID:15315375]. It is also used in traditional medicine to relieve pain [PMID:26243020].
Composés actifs
Major compounds include the flavonoid phloretin-3',5'-di-C-glucoside [PMID:23428403], xanthones such as mangiferin and isomangiferin [PMID:15315375, PMID:19791506, PMID:19272608], and flavanones including hesperidin, narirutin, and eriocitrin [PMID:15315375, PMID:19791506]. Other identified constituents include pinitol, shikimic acid, p-coumaric acid, 4-glucosyltyrosol, epigallocatechin gallate, the isoflavone orobol, flavones luteolin, 5-deoxyluteolin, and scolymoside [PMID:15315375].
Mécanisme d'action
Honeybush extracts exhibit antioxidant and anti-inflammatory activities [PMID:19032980, PMID:32405387]. Specific mechanisms include the inhibition of adipogenesis via decreased PPARγ2 expression [PMID:23428403], anti-degranulation activity in allergic responses [PMID:38966058], and the suppression of HMGB1-mediated septic responses, including the inhibition of proinflammatory proteins and leukocyte adhesion [PMID:26243020]. In cancer cells, extracts may induce cell death via autophagy and ATP depletion [PMID:39139978].
Preuves cliniques
Preuve DObesity (In vitro/Animal)
Hot water extracts of C. subternata inhibit adipogenesis and intracellular triglyceride accumulation in 3T3-L1 pre-adipocytes [PMID:23428403].
Preuve DUV-induced skin damage (Animal)
Topical application of honeybush extracts reduced signs of sunburn (erythema, peeling, hardening) and reduced epidermal hyperplasia and COX-2 induction in SKH-1 mice [PMID:21435898].
Preuve DAllergy (Animal)
Extracts significantly suppressed anaphylactic reaction-induced body temperature decline and inhibited antigen-antibody-induced degranulation in a murine model [PMID:38966058].
Preuve DSepsis (In vitro/Animal)
Active compounds vicenin-2 and scolymoside inhibited lipopolysaccharide-induced release of HMGB1 and suppressed septic responses in HUVECs and mice [PMID:26243020].
Preuve DCancer (In vitro)
C. subternata extracts reduced cell viability and inhibited proliferation in human liver (HepG2) and colon (HT-29) cancer cells [PMID:39139978]. A specific extract (SM6Met) showed synergistic inhibition of MCF7 breast cancer cell proliferation when combined with tamoxifen [PMID:36210845].
Sécurité et effets indésirables
No adverse effects of honeybush consumption as tisanes have been reported [PMID:16927447].
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant antioxidant, anti-inflammatory, and photoprotective properties. There are no reported human clinical trials.
Sources PubMed
1.PMID: 27618035 (2016) — Polyphenols and Sunburn. · International journal of molecular sciences
2.PMID: 23428403 (2013) — Cyclopia maculata and Cyclopia subternata (honeybush tea) inhibits adipogenesis in 3T3-L1 pre-adipocytes. · Phytomedicine : international journal of phytotherapy and phytopharmacology
3.PMID: 15315375 (2004) — Phenolic metabolites from honeybush tea (Cyclopia subternata). · Journal of agricultural and food chemistry
4.PMID: 37299160 (2023) — Analysis of the Differentially Expressed Proteins and Metabolic Pathways of Honeybush (Cyclopia subternata) in Response to Water Deficit Stress. · Plants (Basel, Switzerland)
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Biocontrol of Fusarium Species Utilizing Indigenous Rooibos and Honeybush Extracts.
· Microbiology spectrum
6.PMID: 32405387 (2020) — Effects of honeybush (Cyclopia subternata) extract on physico-chemical, oxidative and sensory traits of typical Italian salami. · Food science & nutrition
7.PMID: 35033263 (2022) — Class-modelling of overlapping classes. A two-step authentication approach. · Analytica chimica acta
8.PMID: 19032980 (2009) — Honeybush (Cyclopia sp.) - a rich source of compounds with high antimutagenic properties. · Fitoterapia
9.PMID: 32831989 (2020) — Honeybush Extracts (Cyclopia spp.) Rescue Mitochondrial Functions and Bioenergetics against Oxidative Injury. · Oxidative medicine and cellular longevity
10.PMID: 23222906 (2012) — Food ingredient extracts of Cyclopia subternata (Honeybush): variation in phenolic composition and antioxidant capacity. · Molecules (Basel, Switzerland)
11.PMID: 35249566 (2022) — Entomopathogenic nematodes associated with organic honeybush (Cyclopia spp.) cultivation in South Africa. · Journal of helminthology
12.PMID: 19791506 (2009) — In vitro cultures of Cyclopia plants (honeybush) as a source of bioactive xanthones and flavanones. · Zeitschrift fur Naturforschung. C, Journal of biosciences
13.PMID: 19272608 (2009) — Isolation of isomangiferin from honeybush (Cyclopia subternata) using high-speed counter-current chromatography and high-performance liquid chromatography. · Journal of chromatography. A
14.PMID: 27367721 (2016) — Mangiferin and Cancer: Mechanisms of Action. · Nutrients
15.PMID: 22394400 (2012) — Characterization of volatiles and aroma-active compounds in honeybush (Cyclopia subternata) by GC-MS and GC-O analysis. · Journal of agricultural and food chemistry
16.PMID: 38966058 (2024) — Anti-allergic effect of Cyclopia (honeybush) extracts via anti-degranulation activity in a murine allergy model for inhaled antigen. · Bioscience of microbiota, food and health
17.PMID: 39139978 (2024) — Autophagy-induced cell death by aqueous and polyphenol-enriched extracts of honeybush (Cyclopia spp.) in liver and colon cancer cells. · Food science & nutrition
18.PMID: 28417179 (2017) — Analysis of honeybush tea (Cyclopia spp.) volatiles by comprehensive two-dimensional gas chromatography using a single-stage thermal modulator. · Analytical and bioanalytical chemistry
19.PMID: 37242784 (2023) — Photoprotection and Antiaging Activity of Extracts from Honeybush (Cyclopia sp.)-In Vitro Wound Healing and Inhibition of the Skin Extracellular Matrix Enzymes: Tyrosinase, Collagenase, Elastase and Hyaluronidase. · Pharmaceutics
20.PMID: 26243020 (2015) — Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo. · Canadian journal of physiology and pharmacology
21.PMID: 23872960 (2013) — Isoflavone production in Cyclopia subternata Vogel (honeybush) suspension cultures grown in shake flasks and stirred-tank bioreactor. · Applied microbiology and biotechnology
22.PMID: 16927447 (2007) — A review of the bioactivity of South African herbal teas: rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia). · Phytotherapy research : PTR
23.PMID: 25355549 (2014) — Anti-wrinkle effects of fermented and non-fermented Cyclopia intermedia in hairless mice. · BMC complementary and alternative medicine
24.PMID: 19916502 (2010) — Effect of pre-drying treatments and storage on color and phenolic composition of green honeybush (Cyclopia subternata) herbal tea. · Journal of agricultural and food chemistry
25.PMID: 32164369 (2020) — Pharmacological Activity of Honeybush (Cyclopia intermedia) in Boar Spermatozoa during Semen Storage and under Oxidative Stress. · Animals : an open access journal from MDPI
26.PMID: 31882089 (2020) — Development of chemical-based reference standards for rooibos and honeybush aroma lexicons. · Food research international (Ottawa, Ont.)
27.PMID: 41316849 (2025) — The Sensory and Physicochemical Properties of Honeybush Tea Depend on the Brewing Water: A Preliminary Study. · Journal of food science
28.PMID: 23880330 (2013) — Cyclopia maculata (honeybush tea) stimulates lipolysis in 3T3-L1 adipocytes. · Phytomedicine : international journal of phytotherapy and phytopharmacology
29.PMID: 36210845 (2022) — Combinatorial treatments of tamoxifen and SM6Met, an extract from Cyclopia subternata Vogel, are superior to either treatment alone in MCF-7 cells. · Frontiers in pharmacology
30.PMID: 21435898 (2011) — Photoprotection by honeybush extracts, hesperidin and mangiferin against UVB-induced skin damage in SKH-1 mice. · Journal of photochemistry and photobiology. B, Biology