Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Daniellia oliveri oleoresin contains beta-caryophyllene, a sesquiterpene that activates CB2 cannabinoid receptors to modulate inflammatory pathways. The diterpenes and sesquiterpenes inhibit pro-inflammatory mediators including prostaglandins and cytokines. Tannins contribute astringent and antioxidant properties that support wound healing. This multi-compound mechanism explains its traditional effectiveness for joint pain and inflammatory skin conditions. Evidence level: C (preliminary pharmacological studies).
Can I take Daniellia oliveri with other medications?
Daniellia oliveri may interact with NSAIDs and anticoagulant medications, potentially increasing bleeding risk through additive anti-inflammatory effects. The oleoresin may affect liver enzymes responsible for drug metabolism. Due to potential kidney irritation, combining internal use with nephrotoxic medications is contraindicated. Always consult a healthcare provider before combining with prescription medications. Evidence level: D (theoretical based on constituent properties).
What is the proper dosage of Daniellia oliveri?
For topical use, the oleoresin can be applied directly to affected joints or skin areas 2-3 times daily. Internal use requires professional supervision due to potential kidney irritation and lacks standardized dosing guidelines. Traditional practitioners may prescribe small, monitored doses for respiratory conditions. Always consult a qualified herbalist before internal use. Evidence level: C (traditional use with limited clinical data).
Is Daniellia oliveri safe during pregnancy?
No, Daniellia oliveri is contraindicated during pregnancy. The oleoresin contains compounds that may stimulate uterine contractions, posing risks of miscarriage or premature labor. Both internal and topical use should be avoided by pregnant women. Breastfeeding women should also avoid this herb due to insufficient safety data regarding infant exposure. Evidence level: D (traditional contraindication).
What are the side effects of Daniellia oliveri?
Reported side effects include skin sensitization and allergic contact dermatitis with topical application. Internal use may cause kidney irritation, particularly with prolonged or high-dose administration. Individuals with pre-existing kidney disease should avoid internal use entirely. Discontinue use immediately if skin rash, itching, or urinary changes occur and seek medical attention. Evidence level: C (reported adverse effects).
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 23 articles PubMed · modèle : gemma4:31b
Résumé
Daniellia oliveri is a tropical tree of the Fabaceae family used in traditional medicine across Africa for treating inflammatory, infectious, and neurological conditions [PMID:37810056, 32774429].
Contexte
Daniellia oliveri (also known as the African Copaiba Balsam Tree) is a member of the Detarioideae subfamily of the legume family (Fabaceae) found in savannahs [PMID:37810056, 32028029].
Usages traditionnels
Indigenous uses include the management of diabetes mellitus, tuberculosis, fever, ulcers, pain, pneumonia, skin ailments, infectious diseases, sickle cell anaemia [PMID:37810056], inflammatory diseases, rheumatism, chest pain, toothache, and lumbago [PMID:36868442]. It is also used in the treatment of schizophrenia, epilepsy [PMID:32774429], infectious diarrhea [PMID:34007296], intertrigo and candidiasis [PMID:36551356], and as a mosquito repellent via the smoke of its bark [PMID:9924960, 10083750].
Composés actifs
Secondary metabolites identified include polyphenols, flavonoids, saponins, alkaloids [PMID:37810056], tannins, and cardiac and cyanogenetic glycosides [PMID:10441783, 10441782]. Specific compounds identified via in silico or chemical analysis include beta-carotene, beta-amyrin, cis-Calamenene [PMID:40056709], and carotenoid K, cadala-1(10),3,8-triene, valencene, and beta-sesquiphellandrene [PMID:40524946].
Mécanisme d'action
The leaf extract may inhibit the influx of extracellular Ca(2+) by inhibiting K(+) channels [PMID:10441783]. The bark extract may interfere with transmitter release and act on multiple sites in skeletal muscle [PMID:10441783] and acts as a noncompetitive antagonist for muscarinic receptors in bladder smooth muscle [PMID:10441782]. In silico studies suggest compounds may act as quorum sensing inhibitors for Acinetobacter baumannii (BfmR/RstA) [PMID:40056709] and Escherichia coli (SdiA) [PMID:40524946].
Preuves cliniques
Preuve DInflammation and Pain
Stem bark extract demonstrated anti-inflammatory and antinociceptive activities in animal models (xylene-induced paw oedema and acetic acid-induced writhing) [PMID:36868442]
Preuve DAmnesia (Diazepam-induced)
Aqueous root bark extract decreased diazepam-induced amnesia and provided neuroprotection in mice [PMID:32774429]
Preuve DDiarrhea
Leaf n-butanol extracts provided 60-80% protection against castor oil-induced diarrhea in mice and caused dose-dependent relaxation of isolated rabbit jejunum [PMID:20161921]
Preuve DBacterial Infections
Raw extracts and fractions showed antibacterial activity with MICs ranging from 16 to 256 μg/mL, though no antifungal activity was observed at 25 μg/mL [PMID:36551356]
Sécurité et effets indésirables
Acute toxicity tests in mice using the limit test for stem bark extract [PMID:36868442] and a single dose of 2000 mg/kg for aqueous/hydroethanolic extracts [PMID:34007296] were conducted; leaf extracts showed an i.p LD(50) > 4000 mg/kg in mice [PMID:20161921].
Synthèse des preuves
The current evidence is primarily based on in vitro studies, in silico modeling, and animal models (Level D). There are no human clinical trials provided in the abstracts.
Sources PubMed
1.PMID: 37810056 (2023) — A review of indigenous knowledge and ethnopharmacological significance of African Copaiba Balsam Tree, Daniellia oliveri (Fabaceae). · Heliyon
2.PMID: 36868442 (2023) — Anti-inflammatory and antinociceptive activities of Daniellia oliveri (Fabaceace) stem bark extract. · Journal of ethnopharmacology
3.PMID: 34099047 (2021) — Filaricidal activity of Daniellia oliveri and Psorospermum febrifugum extracts. · Parasites & vectors
4.PMID: 36551356 (2022) — Daniellia oliveri (Rolfe) Hutch and Dalziel: Antimicrobial Activities, Cytotoxicity Evaluation, and Phytochemical Identification by GC-MS. · Antibiotics (Basel, Switzerland)
5.PMID: 32774429 (2020) — Aqueous Root Bark Extract of Daniellia oliveri (Hutch. & Dalz.) (Fabaceae) Protects Neurons against Diazepam-Induced Amnesia in Mice.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
· Evidence-based complementary and alternative medicine : eCAM
6.PMID: 32028029 (2020) — Phylogeny and biogeography of the Daniellia clade (Leguminosae: Detarioideae), a tropical tree lineage largely threatened in Africa and Madagascar. · Molecular phylogenetics and evolution
7.PMID: 31297686 (2020) — Concentrate replacement with Daniellia oliveri foliage in goat diets. · Tropical animal health and production
8.PMID: 40056709 (2025) — Modulating Acinetobacter baumannii BfmR (RstA) drug target: Daniellia oliveri compounds as RstA quorum sensing inhibitors. · Computational biology and chemistry
9.PMID: 10441783 (1999) — Effects of Daniellia oliveri stem bark and leaf extracts on rat skeletal muscle. · Phytotherapy research : PTR
10.PMID: 40524946 (2025) — In Silico Bioprospection of Daniellia oliveri-Based Products as Quorum Sensing Modulators of Escherichia coli SdiA. · Biochemistry research international
11.PMID: 34007296 (2021) — Toxicological Characterization of Ten Medicinal Plants of the Beninese Flora Used in the Traditional Treatment of Diarrheal Diseases. · Evidence-based complementary and alternative medicine : eCAM
12.PMID: 9924960 (1999) — Plant products used as mosquito repellents in Guinea Bissau, West Africa. · Acta tropica
13.PMID: 10441782 (1999) — Effects of Daniellia oliveri bark on isolated rat bladder. · Phytotherapy research : PTR
14.PMID: 20161921 (2007) — Anti-diarrheal activity of the leaf extracts of Daniellia oliveri Hutch and Dalz (Fabaceae) and Ficus sycomorus Miq (Moraceae). · African journal of traditional, complementary, and alternative medicines : AJTCAM
15.PMID: 15567251 (2004) — Phytochemical and antimicrobial activities of the Daniellia oliveri leaves. · Fitoterapia
16.PMID: 34540993 (2021) — Percentage Destabilization Effect of Some West African Medicinal Plants on the Outer Membrane of Various Bacteria Involved in Infectious Diarrhea. · BioMed research international
17.PMID: 10083750 (1999) — Comparison of plant products and pyrethroid-treated bed nets for protection against mosquitoes (Diptera: Culicidae) in Guinea Bissau, West Africa. · Journal of medical entomology
18.PMID: 25863959 (2015) — Effect of browse plant foliage supplementation on the performance of buckling goats fed threshed sorghum top basal diet. · Tropical animal health and production
19.PMID: 27010715 (2016) — Effects of supplementation of threshed sorghum top with selected browse plant foliage on haematology and serum biochemical parameters of Red Sokoto goats. · Tropical animal health and production
20.PMID: 31350736 (2019) — In Vitro Modulation of Glibenclamide Transport by P-glycoprotein Inhibitory Antidiabetic African Plant Extracts. · Planta medica
21.PMID: 12881406 (2003) — Structure of pollen apertures in the Detarieae sensu stricto (Leguminosae: Caesalpinioideae), with particular reference to underlying structures (Zwischenkörper). · Annals of botany