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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Salvia miltiorrhiza, known as Danshen, is a traditional Chinese medicinal herb widely used for treating cardiovascular and cerebrovascular diseases [PMID: 33430756, 30923500].
Contexte
Danshen (Salvia miltiorrhiza Bunge) is a perennial plant of the Lamiaceae family native to China and Japan [PMID: 30923500, 32089238, 40720694]. The medicinal part is the dried root and rhizome [PMID: 28828985, 32089238].
Usages traditionnels
It has been used for hundreds of years in Traditional Chinese Medicine to treat cardiovascular diseases, cerebrovascular diseases, and skeletal diseases [PMID: 28828985, 30923500, 25109459]. It is also associated with promoting blood circulation and removing blood stasis (Huoxue Huayu) [PMID: 24123144].
Composés actifs
The primary bioactive constituents are divided into lipophilic tanshinones (e.g., tanshinone I, IIA, IIB, cryptotanshinone, and dihydrotanshinone) and hydrophilic phenolic acids (e.g., salvianolic acids A, B, and C, rosmarinic acid, and danshensu) [PMID: 28828985, 30923500, 31338034, 35600860]. Other components include polysaccharides, diterpenoid quinones, and triterpenes [PMID: 36937857, 37648044, 28766764].
Mécanisme d'action
Danshen exhibits anti-oxidative stress, anti-inflammatory, and anti-thrombotic functions [PMID: 33430756]. It improves endothelial function, promotes vasodilation, inhibits platelet aggregation, and reduces the proliferation and migration of vascular smooth muscle cells [PMID: 40469984, 31338034]. In cancer, it may induce apoptosis, autophagy, and cell cycle arrest by interfering with microRNAs and epigenetic enzymes [PMID: 36172186, 35600860].
Preuves cliniques
Preuve BPrimary Hypertension
A randomized, double-blind, placebo-controlled trial showed a significant reduction in systolic and diastolic blood pressure in the intervention group receiving intravenous Salvia miltiorrhiza [PMID: 40658027]
Clinical trials indicated that DanShen was an effective medicine for angina pectoris, myocardial infarction, and stroke [PMID: 11603281]
Preuve CCardiovascular Diseases
Preparations in combination with Western medicine were reported to be more effective for treating angina pectoris, myocardial infarction, hypertension, hyperlipidemia, and pulmonary heart diseases [PMID: 31338034]
Preuve ACancer
Tanshinones and phenolic acids have demonstrated potent anticancer activities both in vitro and in vivo [PMID: 24123144, 36386172]
Grossesse et allaitement
S. miltiorrhiza and its active compounds are suggested to potentially attenuate symptoms of placenta-mediated pregnancy complications (PMPCs) such as preeclampsia and fetal growth restriction through anticoagulation and endothelial protection [PMID: 36711034].
Synthèse des preuves
Evidence is strongest for cardiovascular applications and anticancer potential, with a mix of systematic reviews, clinical trials, and extensive in vitro/in vivo research. One recent RCT supports its use in hypertension management.
Sources PubMed
1.PMID: 33430756 (2021) — Salvia miltiorrhiza in Anti-diabetic Angiopathy. · Current molecular pharmacology
2.PMID: 11603281 (2000) — Salvia miltiorrhiza and ischemic diseases. · Acta pharmacologica Sinica
3.PMID: 28828985 (2017) — Danshen (Salvia miltiorrhiza Bunge): A Prospective Healing Sage for Cardiovascular Diseases. · Current pharmaceutical design
4.PMID: 30923500 (2019) — Tanshinones, Critical Pharmacological Components in Salvia miltiorrhiza. · Frontiers in pharmacology
5.PMID: 25109459 (2014) — Salvia miltiorrhiza: an ancient Chinese herbal medicine as a source for anti-osteoporotic drugs. · Journal of ethnopharmacology
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 40750518 (2025) — Salvia miltiorrhiza components and gut microbiota interactions in Helicobacter pylori infection. · Journal of integrative medicine
7.PMID: 40658027 (2025) — Effects of Dan Shen (Salvia miltiorrhiza) on blood pressure management in hypertensive patients: a randomized controlled trial. · Blood pressure
8.PMID: 24123144 (2014) — The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review. · Medicinal research reviews
9.PMID: 36711034 (2023) — Effects of Salvia miltiorrhiza active compounds on placenta-mediated pregnancy complications. · Frontiers in cell and developmental biology
10.PMID: 35358599 (2022) — MAPKK2/4/5/7-MAPK3-JAZs modulate phenolic acid biosynthesis in Salvia miltiorrhiza. · Phytochemistry
11.PMID: 37030588 (2023) — The tanshinones from the plant of Salvia miltiorrhiza. · Phytochemistry
12.PMID: 32089238 (2020) — Pharmacological properties of tanshinones, the natural products from Salvia miltiorrhiza. · Advances in pharmacology (San Diego, Calif.)
13.PMID: 40720694 (2025) — Biosynthesis and regulatory mechanism of tanshinones and phenolic acids in Salvia miltiorrhiza. · The Plant journal : for cell and molecular biology
14.PMID: 33597880 (2020) — Tanshinone IIA: A Review of its Anticancer Effects. · Frontiers in pharmacology
15.PMID: 37648044 (2023) — Salviamilthone A-O, diterpenoid quinones from Salvia miltiorrhiza. · Phytochemistry
16.PMID: 36937857 (2023) — Recent developments in Salvia miltiorrhiza polysaccharides: Isolation, purification, structural characteristics and biological activities. · Frontiers in pharmacology
17.PMID: 40469984 (2025) — Anti-atherosclerotic effects and molecular targets of salvianolic acids from Salvia miltiorrhiza Bunge. · Frontiers in pharmacology
18.PMID: 36172186 (2022) — Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes. · Frontiers in pharmacology
19.PMID: 35126100 (2021) — Salvia miltiorrhiza Bge. (Danshen) for Inflammatory Bowel Disease: Clinical Evidence and Network Pharmacology-Based Strategy for Developing Supplementary Medical Application. · Frontiers in pharmacology
20.PMID: 36386172 (2022) — Salvianolic acid B from Salvia miltiorrhiza bunge: A potential antitumor agent. · Frontiers in pharmacology
21.PMID: 34833133 (2021) — Salvia miltiorrhiza Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress. · Life (Basel, Switzerland)
22.PMID: 31338034 (2019) — Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications. · Frontiers in pharmacology
23.PMID: 28766764 (2017) — Bioactive Triterpenes from the Root of Salvia miltiorrhiza Bunge. · Phytotherapy research : PTR
24.PMID: 32933217 (2020) — Overview of Salvia miltiorrhiza as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action. · Antioxidants (Basel, Switzerland)
25.PMID: 37842784 (2024) — Metabolomic and antioxidant analyses of Salvia miltiorrhiza Bunge and Salvia prattii Hemsl. seeds. · Natural product research
26.PMID: 30609767 (2019) — Biosynthesis, Chemistry, and Pharmacology of Polyphenols from Chinese Salvia Species: A Review. · Molecules (Basel, Switzerland)
27.PMID: 36869860 (2024) — Salvia miltiorrhiza augments endothelial cell function for ischemic hindlimb recovery. · Biological chemistry
28.PMID: 35600860 (2022) — Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms. · Frontiers in pharmacology
29.PMID: 38542838 (2024) — Research Progress on Regulation of Immune Response by Tanshinones and Salvianolic Acids of Danshen (Salvia miltiorrhiza Bunge). · Molecules (Basel, Switzerland)