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DD
Not CommonGénéré par IA
Djibouti Desert Tamarisk
Tamarix aphylla
traitement des affections cutanées en médecine populaire de l'Horn de l'Afrique
How does Tamarix aphylla work as an anti-inflammatory?
Tamarix aphylla contains bioactive compounds including tamarixetin, quercetin, gallic acid, and tannins that contribute to its medicinal effects. These flavonoids and phenolic compounds exhibit anti-inflammatory and antioxidant activity by modulating inflammatory pathways and neutralizing free radicals. The high tannin content provides astringent properties, making it effective for skin conditions and digestive complaints. Evidence level: C (preliminary research and traditional use).
Does Tamarix aphylla interact with any medications?
Tamarix aphylla contains significant tannin content, which may reduce the absorption of certain medications and minerals, particularly iron supplements. Taking this herb separately from medications by at least 2 hours is generally recommended. Limited formal interaction studies exist (Evidence level: C). Patients taking prescription medications should consult a healthcare provider before use, especially those on iron therapy or medications affected by tannin binding.
What is the recommended dosage for Tamarix aphylla bark decoction?
The traditional adult dosage for Tamarix aphylla is 2-4 grams of dried bark or leaf prepared as a decoction. This amount provides therapeutic levels of active compounds including tannins and flavonoids. The decoction is typically prepared by simmering the plant material in water for 10-15 minutes. Dosage recommendations are based on traditional use and preliminary research (Evidence level: C). Starting with lower doses helps assess individual tolerance.
Is Tamarix aphylla safe to use during pregnancy?
Based on traditional use in Horn of Africa folk medicine, Tamarix aphylla is generally considered safe during pregnancy when used at recommended doses. However, limited clinical research exists specifically examining safety in pregnant populations (Evidence level: C). Pregnant women should consult a qualified healthcare provider before using any herbal preparations. The astringent properties from tannins may cause mild digestive effects in sensitive individuals.
What is Tamarix aphylla used for in traditional medicine?
Tamarix aphylla has been used traditionally in Horn of Africa folk medicine for treating various skin conditions including wounds, rashes, and infections due to its astringent and antimicrobial properties. It is also employed as a digestive astringent for managing diarrhea and gastrointestinal discomfort. Additionally, the plant has been used for its anti-inflammatory properties to address inflammatory conditions. These uses are supported by traditional knowledge and preliminary phytochemical research (Evidence level: C).
What are the side effects of Tamarix aphylla?
The primary side effect associated with Tamarix aphylla is constipation, which occurs due to the high tannin content when the herb is used excessively or for prolonged periods. Tannins have strong astringent properties that can slow digestive transit. Individuals with pre-existing constipation should avoid this herb entirely. Other potential effects include mild stomach discomfort in sensitive individuals. Adhering to recommended dosages of 2-4g daily typically minimizes adverse effects (Evidence level: C, Traditional).
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Tamarix aphylla is a perennial halophytic tree found in Asia, the Middle East, and Central Africa, recognized for its diverse pharmacological properties including anti-inflammatory and antimicrobial activities [PMID:35009121].
Contexte
Tamarix aphylla, also known as Athel tamarisk, is a drought-resistant phreatophyte that thrives in arid, hypersaline conditions [PMID:37903263, PMID:39053515]. It is characterized by its ability to excrete concentrated salt solutions and possesses robust erosion-resistant characteristics [PMID:37903263, PMID:24305989].
Usages traditionnels
It has been used in traditional medicine as a carminative diuretic for tuberculosis, leprosy, and hepatitis [PMID:35009121], as well as an astringent, anti-rheumatic agent, and for the treatment of fever [PMID:27517880].
Composés actifs
The plant is rich in polyphenols, including phenolic acids (gallic, caffeic, p-coumaric, ferulic, ellagic, syringic, and 3-hydroxybenzoic acids) and flavonoids (kaempferol, quercetin, and isorhamnetin) [PMID:27517880, PMID:38558274]. Other identified constituents include ellagitannins, gallotannins, and gallo-ellagitannins in the galls [PMID:25987319], as well as aromatic and volatile compounds such as Benzeneselenol, Gibberellic acid, and Triaziquone [PMID:36677418].
Mécanisme d'action
Anti-inflammatory effects are mediated through the inhibition of intracellular reactive oxygen species (ROS) production, nitric oxide (NO) generation, and T-cell proliferation [PMID:32630007], and by modulating TNF-α, IL-1β, COX-2, and NO levels [PMID:38273280]. Gastroprotective effects are associated with the modulation of the MAPK signaling pathway and the PTGS2 gene [PMID:38728332].
Preuves cliniques
Preuve DInflammation
T. aphylla demonstrated anti-inflammatory activity in Wistar albino rats by reducing levels of TNF-α, IL-1β, COX-2, and NO in inflamed paw tissue [PMID:38273280].
Preuve DGastric Ulcers
Leaves crude extract ameliorated indomethacin-induced gastric ulcers in rats by modulating the MAPK signaling pathway and alleviating oxidative stress [PMID:38728332].
Preuve DHepatotoxicity
Ethanolic extract of T. aphylla showed hepato-protective ability against sodium arsenite-induced liver injury in rats [PMID:36190635].
Preuve DAcid-Burn Wounds
A nanoemulsion cream containing T. aphylla extract was evaluated for efficacy in healing acid-burn wounds in rabbits [PMID:36676658].
Preuve DFungal Infections
Water and ethanolic extracts showed fungicidal properties against Macrophomina phaseolina, Curvularia spicifera, and Fusarium spp. [PMID:36677418].
Preuve DBacterial Virulence
Sécurité et effets indésirables
An acute oral toxicity assay in Wistar rats using graded doses up to 4 g/kg indicated that T. aphylla is generally safe [PMID:38273280].
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant potential for anti-inflammatory, antioxidant, and antimicrobial applications, though human clinical trials are lacking.
Sources PubMed
1.PMID: 35009121 (2021) — Pharmacological Efficacy of Tamarix aphylla: A Comprehensive Review. · Plants (Basel, Switzerland)
2.PMID: 36677418 (2023) — The Antifungal Properties of Tamarix aphylla Extract against Some Plant Pathogenic Fungi. · Microorganisms
3.PMID: 24305989 (2013) — Active anti-erosion protection strategy in tamarisk (Tamarix aphylla). · Scientific reports
4.PMID: 37903263 (2023) — Harvesting of aerial humidity with natural hygroscopic salt excretions. · Proceedings of the National Academy of Sciences of the United States of America
5.PMID: 22908641 (2012) — Enhanced dissipation of polycyclic aromatic hydrocarbons in the rhizosphere of the Athel tamarisk (Tamarix aphylla L. Karst.) grown in saline-alkaline soils of the former lake Texcoco.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Ethanolic extract was explored for its activity against the SpaP virulence gene in multidrug-resistant Streptococcus mutans [PMID:37575558].
Preuve DCancer Cell Proliferation
Aqueous and ethanol extracts exhibited dose-dependent cytotoxicity, with potent effects specifically predicted against MCF-7 breast adenocarcinoma cells [PMID:30034503].
· International journal of phytoremediation
6.PMID: 37575558 (2023) — Assessment of the Antivirulence Potential of Tamarix aphylla Ethanolic Extract against Multidrug-Resistant Streptococcus mutans Isolated from Iraqi Patients. · TheScientificWorldJournal
7.PMID: 32630007 (2020) — Anti-Inflammatory Principles from Tamarix aphylla L.: A Bioassay-Guided Fractionation Study. · Molecules (Basel, Switzerland)
8.PMID: 39053515 (2024) — Surviving the desert's grasp: Decipherment phreatophyte Tamarix aphylla (L.) Karst. Adaptive strategies for arid resilience. · Plant science : an international journal of experimental plant biology
9.PMID: 38558274 (2024) — Assessing the Chemical Profile and Biological Potentials of Tamarix aphylla (L.) H.Karst. and Tamarix senegalensis DC. by In Vitro, In Silico, and Network Methodologies. · Applied biochemistry and biotechnology
10.PMID: 38273280 (2024) — Involvement of TNFα, IL-1β, COX-2 and NO in the anti-inflammatory activity of Tamarix aphylla in Wistar albino rats: an in-vivo and in-vitro study. · BMC complementary medicine and therapies
11.PMID: 25987319 (2015) — Ellagitannins, gallotannins, and gallo-ellagitannins from the galls of Tamarix aphylla. · Fitoterapia
12.PMID: 27517880 (2016) — Evaluation of Antioxidant, Anticholinesterase, and Antidiabetic Potential of Dry Leaves and Stems in Tamarix aphylla Growing Wild in Tunisia. · Chemistry & biodiversity
13.PMID: 38728332 (2024) — Tamarix aphylla derived metabolites ameliorate indomethacin-induced gastric ulcers in rats by modulating the MAPK signaling pathway, alleviating oxidative stress and inflammation: In vivo study supported by pharmacological network analysis. · PloS one
14.PMID: 36676658 (2022) — The Therapeutic Application of Tamarix aphylla Extract Loaded Nanoemulsion Cream for Acid-Burn Wound Healing and Skin Regeneration. · Medicina (Kaunas, Lithuania)
15.PMID: 30034503 (2018) — Potential Antiproliferative Activity and Evaluation of Essential Oil Composition of the Aerial Parts of Tamarix aphylla (L.) H.Karst.: A Wild Grown Medicinal Plant in Jordan. · Evidence-based complementary and alternative medicine : eCAM
16.PMID: 36190635 (2023) — Mechanistic insights on the possible protective role of polyphenols extracted from Tamarix aphylla aerial parts against sodium arsenite-induced hepatotoxicity in rats. · Environmental science and pollution research international