Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
EH
Not CommonGénéré par IA
Euphorbia Hirta Plant
Euphorbia hirta
asthme et bronchite en médicine asiatique traditionnelle
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Euphorbia hirta is a tropical weed used in traditional medicine across Asia and the Philippines for various ailments, including respiratory disorders and dengue [PMID: 29849664, 35187071, 39290882].
Contexte
Euphorbia hirta, also known as Tawa-Tawa, is a common roadside weed found in tropical Asia and India [PMID: 29849664, 40061658].
Usages traditionnels
Traditionally used to treat respiratory ailments, dysentery, jaundice, digestive problems, and diarrhea [PMID: 35455080, 39290882]. In the Philippines, it is used in folklore medicine for the treatment of dengue [PMID: 29849664]. In India, Indonesia, and Angola, it has been used as a galactagogue and to improve colostrum quality [PMID: 30000943].
Composés actifs
Identified constituents include flavonoids (such as Quercetin-3-O-alpha-rhamnoside and kaempferol), saponins, sterols (beta-sitosterol), terpenes (alpha-amyrin, beta-amyrin, lupeol, taraxerone), alkaloids, polyphenols, tannins, and mucilage [PMID: 25598628, 27033089, 28479737, 40061658]. Other identified compounds include heneicosane, tetracosane, phytol, and squalene [PMID: 40061720, 40061658].
Mécanisme d'action
Anti-inflammatory effects are mediated through the modulation of Nrf2 and NF-kappaB signaling pathways [PMID: 39505796]. In human keratinocytes, it suppresses TNF-alpha/IFN-gamma-induced inflammatory responses by down-regulating JNK or STAT1/3 pathways [PMID: 35455080]. It also suppresses the release of TNF-alpha and IL-6 from activated rat peritoneal mast cells [PMID: 17643865].
Preuves cliniques
Preuve CDengue
Used in folklore medicine; a systematic review identified one human trial, though limited studies have been conducted on antidengue activity [PMID: 29849664]
Preuve DHepatotoxicity (CCl4-induced)
Ethanolic extracts exhibited potential in vitro antioxidant activity and protective effects in Wistar rats [PMID: 36268597]
Preuve DSnake Venom Toxicity
Quercetin-3-O-alpha-rhamnoside inhibited protease, phospholipase-A(2), hemolytic activity, and hemorrhage inducing activity of Naja naja venom in vitro and in mice models [PMID: 27033089]
Preuve DGastroesophageal Reflux Disease (GERD)
Whole plant extract and flavonoids were investigated in surgically induced GERD models in rats [PMID: 28479737]
Preuve DAnaphylaxis
Ethanolic extract showed anti-anaphylactic activity against compound 48/80-induced systemic anaphylaxis in rats and mice [PMID: 17643865]
Preuve D
Sécurité et effets indésirables
Acute toxicity studies indicate the toxic dose may be above 3000 mg/kg [PMID: 25598628]. In silico assessments suggest several phytoconstituents are nontoxic [PMID: 40061720]. However, it has been identified as a potential antigen in air-borne contact dermatitis [PMID: 28150592].
Grossesse et allaitement
Used as a galactagogue in some cultures, but no scientifically valid clinical trials support this use, and no data exist on the excretion of components into breastmilk [PMID: 30000943].
Synthèse des preuves
The evidence is primarily based on in vitro studies, animal models (D), and systematic reviews of folklore use (C). There is a lack of high-level clinical trial data (A or B) to support therapeutic claims in humans.
Sources PubMed
1.PMID: 30000943 (2006) — Lignans from Euphorbia hirta L. · Natural product research
2.PMID: 29849664 (2018) — Potential Use of Euphorbia hirta for Dengue: A Systematic Review of Scientific Evidence. · Journal of tropical medicine
3.PMID: 40061720 (2024) — In Silico toxicity assessment of Euphorbia hirta. · Journal of pharmacy & bioallied sciences
4.PMID: 40061658 (2024) — Determination of Phytochemical Properties "Amman Pacharisi"-Euphorbia hirta Linn. · Journal of pharmacy & bioallied sciences
5.PMID: 25598628 (2015) — Minerals salt composition and secondary metabolites of Euphorbia hirta Linn., an antihyperglycemic plant.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Ethanol extract formulated as a mouthwash demonstrated anti-bacterial effects against Streptococcus mutans [PMID: 35592805]
· Pharmacognosy research
6.PMID: 24359779 (2013) — Triterpenes from Euphorbia hirta and their cytotoxicity. · Chinese journal of natural medicines
7.PMID: 36268597 (2022) — Protective effect of Euphorbia thymifolia and Euphorbia hirta against carbon tetrachloride-induced hepatotoxicity in Wistar rats. · Drug development and industrial pharmacy
8.PMID: 35187071 (2021) — Phytochemicals of Euphorbia hirta L. and Their Inhibitory Potential Against SARS-CoV-2 Main Protease. · Frontiers in molecular biosciences
9.PMID: 35592805 (2022) — Formulation, characteristics and anti-bacterial effects of Euphorbia hirta L. mouthwash. · Journal of Taibah University Medical Sciences
10.PMID: 35455080 (2022) — Euphorbia hirta Leaf Ethanol Extract Suppresses TNF-α/IFN-γ-Induced Inflammatory Response via Down-Regulating JNK or STAT1/3 Pathways in Human Keratinocytes. · Life (Basel, Switzerland)
11.PMID: 39290882 (2024) — A review of ethnobotanical studies reveals over 500 medicinal plants in Mindanao, Philippines. · Plant diversity
12.PMID: 27033089 (2016) — Quercetin-3-O-rhamnoside from Euphorbia hirta protects against snake Venom induced toxicity. · Biochimica et biophysica acta
13.PMID: 28479737 (2017) — Flavonoids from whole Plant of Euphorbia hirta and their Evaluation against Experimentally induced Gastroesophageal Reflux Disease in Rats. · Pharmacognosy magazine
14.PMID: 39505796 (2025) — Flavonoids of Euphorbia hirta inhibit inflammatory mechanisms via Nrf2 and NF-κB pathways. · Cell biochemistry and biophysics
15.PMID: 28150592 (1986) — Air-borne Contact Dermatitis in Varanasi. · Indian journal of dermatology, venereology and leprology
16.PMID: 19943357 (2010) — Molluscicides from some common medicinal plants of eastern Uttar Pradesh, India. · Journal of applied toxicology : JAT
17.PMID: 17643865 (2007) — Anti-anaphylactic effect of Euphorbia hirta. · Fitoterapia