Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Fomes fomentarius contains bioactive compounds including fomentarins, polyphenols, and triterpenoids that contribute to its medicinal effects. These compounds exhibit immunomodulatory and anti-inflammatory properties through modulation of immune cell activity and cytokine production. The polyphenols provide antioxidant activity, while triterpenoids may support wound healing processes. Evidence level C indicates these mechanisms are primarily supported by in vitro and animal studies rather than extensive human trials.
Does Fomes fomentarius interact with any medications?
Fomes fomentarius may interact with immunosuppressant medications due to its immunomodulatory properties. Because it can stimulate immune activity, individuals taking drugs to suppress immune function should avoid this fungus. Additionally, its potential effects on blood clotting suggest caution when combined with anticoagulant or antiplatelet medications. Always consult a healthcare provider before combining Fomes fomentarius with prescription medications. Evidence level C.
What is the recommended dosage for Fomes fomentarius?
The typical adult dosage for Fomes fomentarius is 1-3 grams of extract daily, traditionally divided into smaller doses throughout the day. This can be taken as capsules, tinctures, or powdered extracts mixed with water. Dosage may vary depending on the specific preparation and concentration. Start with the lower end of the range and adjust based on individual response. Consult a qualified herbalist or healthcare provider for personalized dosing recommendations. Evidence level C.
Is Fomes fomentarius safe during pregnancy and breastfeeding?
Fomes fomentarius is considered unsafe during pregnancy and breastfeeding. The immunomodulatory compounds may affect fetal development or infant health, and insufficient safety data exists for these populations. Women who are pregnant, planning to become pregnant, or breastfeeding should avoid this herb entirely. Additionally, individuals with autoimmune conditions should not use Fomes fomentarius as it may stimulate immune activity and worsen symptoms. Evidence level C.
What is Fomes fomentarius used for in traditional medicine?
Fomes fomentarius has been used traditionally across Northern Europe and Siberia for wound healing and as a hemostatic agent to stop bleeding. Folk medicine applications include supporting immune function, reducing inflammation, and promoting tissue repair. Historically, it was also valued as tinder for starting fires. Modern herbalists may recommend it for similar purposes, though clinical evidence remains limited to level C, indicating a need for more rigorous human studies.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Fomes fomentarius, known as the tinder polypore, is a wood-decaying macrofungus with recognized medicinal value and biotechnological applications [PMID:27910753, PMID:37017659].
Contexte
Fomes fomentarius is a white-rot basidiomycete fungus that colonizes coarse wood and standing trees, particularly birch [PMID:20668917, PMID:38535205]. It is characterized by hoof-shaped fruiting bodies and is distributed across North America, Europe, and Asia [PMID:27910753, PMID:37017659].
Usages traditionnels
Traditionally used worldwide as tinder for starting fires, for ritual purposes, in artworks (clothing, frames, ornaments), and to treat human diseases including wounds, gastro-intestinal disorders, liver-related problems, inflammations, and various cancers [PMID:37017659]. In central European folk medicine, it was used for dysmenorrhoea, haemorrhoids, bladder disorders, pyretic diseases, coughs, cancer, and rheumatism [PMID:24786572].
Composés actifs
The fungus contains phenolics, carbohydrates (including beta-glucans and alpha-glucans), minerals, and crude fat [PMID:33822505]. Specific compounds include melanin-like pigments (melanins, lignins, and humic acids), ergosterol peroxide, ergost-7-en-3-one [PMID:33822505, PMID:10963454], and ergostane-type sterols known as fomentarols A-D [PMID:23747096]. It also contains the anti-inflammatory compound methyl 9-oxo-(10E,12E)-octadecadienoate (FF-8) [PMID:26539049] and chitin [PMID:35381153].
Mécanisme d'action
The compound FF-8 attenuates lipopolysaccharide-induced inflammatory responses in murine macrophages by blocking the phosphorylation of STAT3 and downregulating inducible NO synthase and cyclooxygenase-2 expression [PMID:26539049].
Preuves cliniques
Preuve DInflammation (Murine model)
Methyl 9-oxo-(10E,12E)-octadecadienoate (FF-8) suppressed the secretion of nitric oxide, prostaglandin E2, and inflammatory cytokines TNF-α and IL-6 [PMID:26539049]
Preuve DCancer (In vitro)
An aqueous alkali extract showed dose-dependent cytotoxicity against murine fibroblasts (L929) and cutaneous melanoma cells (COLO-818), while human colorectal adenocarcinoma cells (Caco-2) did not react [PMID:36004705]
Preuve DHoney Bee Viruses
Extracts from Fomes mycelium reduced levels of deformed wing virus (DWV) and Lake Sinai virus (LSV) in a dose-dependent manner [PMID:30287824]
Synthèse des preuves
The current evidence is primarily based on in vitro studies, animal models, and traditional use reviews (Level C and D). There are no human clinical trials (Level B) or meta-analyses (Level A) provided in the source material.
Sources PubMed
1.PMID: 27910753 (2016) — Medicinal Value and Taxonomy of the Tinder Polypore, Fomes fomentarius (Agaricomycetes): A Review. · International journal of medicinal mushrooms
2.PMID: 37017659 (2023) — Medicinal Potential of the Insoluble Extracted Fibers Isolated from the Fomes fomentarius (Agaricomycetes) Fruiting Bodies: A Review. · International journal of medicinal mushrooms
3.PMID: 34933689 (2021) — Extrusion-based additive manufacturing of fungal-based composite materials using the tinder fungus Fomes fomentarius. · Fungal biology and biotechnology
4.PMID: 35209941 (2022) — Establishment of the basidiomycete Fomes fomentarius for the production of composite materials. · Fungal biology and biotechnology
5.PMID: 20668917 (2011) — Ecology of coarse wood decomposition by the saprotrophic fungus Fomes fomentarius.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 38049892 (2023) — Mechanical, physical and thermal properties of composite materials produced with the basidiomycete Fomes fomentarius. · Fungal biology and biotechnology
7.PMID: 33822505 (2021) — Chemical Composition and Ultraviolet Absorption Activity of an Aqueous Alkali Extract from the Fruiting Bodies of the Tinder Conk Mushroom, Fomes fomentarius (Agaricomycetes). · International journal of medicinal mushrooms
8.PMID: 23928420 (2013) — Phylogenetic and phenotypic characterization of Fomes fasciatus and Fomes fomentarius in the United States. · Mycologia
9.PMID: 35381153 (2021) — Simplified Colorimetric Determination of Glucosamine in the Tinder Conk Mushroom, Fomes fomentarius (Agaricomycetes). · International journal of medicinal mushrooms
10.PMID: 36812306 (2023) — The complex structure of Fomes fomentarius represents an architectural design for high-performance ultralightweight materials. · Science advances
11.PMID: 10963454 (2000) — Constituents of various wood-rotting basidiomycetes. · Phytochemistry
12.PMID: 33858513 (2021) — An approach to change the basic polymer composition of the milled Fomes fomentarius fruiting bodies. · Fungal biology and biotechnology
13.PMID: 36004705 (2022) — In Vitro Cytotoxic Activity of an Aqueous Alkali Extract of the Tinder Conk Mushroom, Fomes fomentarius (Agaricomycetes), on Murine Fibroblasts, Human Colorectal Adenocarcinoma, and Cutaneous Melanoma Cells. · International journal of medicinal mushrooms
14.PMID: 24786572 (2014) — European medicinal polypores--a modern view on traditional uses. · Journal of ethnopharmacology
15.PMID: 38535205 (2024) — Comparative Transcriptome Analysis Explores the Mechanism of Angiosperm and Gymnosperm Deadwood Degradation by Fomes fomentarius. · Journal of fungi (Basel, Switzerland)
16.PMID: 36226293 (2022) — Wood degradation by Fomitiporia mediterranea M. Fischer: Physiologic, metabolomic and proteomic approaches. · Frontiers in plant science
17.PMID: 29953352 (2018) — Genetic Variability of the Medicinal Tinder Bracket Polypore, Fomes fomentarius (Agaricomycetes), from the Asian Part of Russia. · International journal of medicinal mushrooms
18.PMID: 33669445 (2021) — Unleashing the Biological Potential of Fomes fomentarius via Dry and Wet Milling. · Antioxidants (Basel, Switzerland)
19.PMID: 16821719 (2006) — Primary fluorescence (autofluorescence) of fruiting bodies of the wood-rotting fungus Fomes fomentarius. · Folia microbiologica
20.PMID: 30287824 (2018) — Extracts of Polypore Mushroom Mycelia Reduce Viruses in Honey Bees. · Scientific reports
21.PMID: 39203038 (2024) — Antibacterial Efficacy and Characterization of Silver Nanoparticles Synthesized via Methanolic Extract of Fomes fomentarius L. Fr. · Molecules (Basel, Switzerland)
22.PMID: 38640440 (2024) — Decomposition of Fomes fomentatius fruiting bodies - transition of healthy living fungus into a decayed bacteria-rich habitat is primarily driven by Arthropoda. · FEMS microbiology ecology
23.PMID: 35836854 (2022) — Structural characterization and a novel water-soluble polysaccharide from Fomes Fomentarius. · American journal of translational research
24.PMID: 19413764 (2009) — Effect of culturing processes and copper addition on laccase production by the white-rot fungus Fomes fomentarius MUCL 35117. · Letters in applied microbiology
25.PMID: 31119076 (2019) — The microbiome profiling of fungivorous black tinder fungus beetle Bolitophagus reticulatus reveals the insight into bacterial communities associated with larvae and adults. · PeerJ
26.PMID: 32647621 (2019) — How to resolve cryptic species of polypores: an example in Fomes. · IMA fungus
27.PMID: 36985251 (2023) — Fomes fomentarius and F. inzengae-A Comparison of Their Decay Patterns on Beech Wood. · Microorganisms
28.PMID: 26539049 (2015) — Methyl 9-Oxo-(10E,12E)-octadecadienoate Isolated from Fomes fomentarius Attenuates Lipopolysaccharide-Induced Inflammatory Response by Blocking Phosphorylation of STAT3 in Murine Macrophages. · Mycobiology
29.PMID: 33287923 (2020) — Optimization of fermentation of Fomes fomentarius extracellular polysaccharide and antioxidation of derivatized polysaccharides. · Cellular and molecular biology (Noisy-le-Grand, France)
30.PMID: 23747096 (2013) — Fomentarols A-D, sterols from the polypore macrofungus Fomes fomentarius. · Phytochemistry