Grindelia (Grindelia robusta): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Grindelia work for asthma and bronchitis?

Grindelia contains grindelic acid and diterpene acids that act as bronchial antispasmodics, helping to relax smooth muscle in the airways. The herb also contains saponins that provide expectorant effects, helping to thin and clear mucus from the respiratory tract. Additionally, tannins contribute anti-inflammatory properties. This combination makes Grindelia useful for spasmodic respiratory conditions. Evidence level: C (preliminary evidence from traditional use and pharmacological studies).

Does Grindelia interact with any medications?

Grindelia may interact with medications affecting the heart, kidneys, or cardiovascular system due to its potential cardiac and renal effects at higher doses. It should be used cautiously with diuretics, cardiac glycosides, or blood pressure medications. The herb's effects on the heart could theoretically potentiate or interfere with cardiac drugs. Always consult a healthcare provider before combining Grindelia with prescription medications, especially those for heart or kidney conditions.

What is the recommended dosage for Grindelia?

The typical adult dosage for Grindelia is 1-3ml of tincture taken three times daily, or 1-2 grams of dried herb prepared as a tea. These doses are based on traditional use patterns rather than clinical trials. Due to potential side effects including gastrointestinal and renal irritation, it's advisable to start with lower doses and avoid prolonged use. Consult a qualified herbalist or healthcare provider for personalized dosing recommendations.

Is Grindelia safe to take during pregnancy?

No, Grindelia is considered unsafe during pregnancy. The herb contains compounds that may stimulate uterine contractions or cause cardiac effects that could harm fetal development. Traditional use and pharmacological evidence suggest potential risks to both mother and fetus. Pregnant women should avoid Grindelia entirely. Women who are breastfeeding should also avoid this herb due to insufficient safety data. Always consult a healthcare provider before using any herbs during pregnancy.

Can Grindelia help treat poison ivy rash?

Yes, Grindelia has a long history of traditional use as a remedy for poison ivy dermatitis. Native American peoples used the herb externally as a wash or poultice to soothe the characteristic itching, blistering rash caused by poison ivy exposure. The tannins and other compounds may help reduce inflammation and promote healing of affected skin. Evidence level: C, based primarily on traditional use rather than clinical trials. For severe reactions, seek medical attention.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Grindelia robusta, also known as gumweed, is a medicinal herb of the sunflower family used traditionally for respiratory conditions [PMID: 26119826, PMID: 33938204].

Contexte

Grindelia robusta (gumweed) is a member of the Asteraceae family [PMID: 26119826]. It is characterized by a resinous exudate on its surfaces, particularly on unopened composite flowers [PMID: 26119826].

Usages traditionnels

Historically, it has been used in the treatment of asthma [PMID: 37825252, PMID: 29833417] and chronic bronchitis [PMID: 29833417].

Composés actifs

Major constituents include grindelic acid and related grindelane diterpenoids [PMID: 26119826]. Phenolic compounds identified include flavonoids (such as diosmetin-7-O-glucuronide-3'-O-pentoside and apigenin-7-O-glucuronide) and hydroxycinnamic acids [PMID: 24603350]. Essential oils contain borneol, alpha-pinene, trans-pinocarveol, bornyl acetate, and limonene [PMID: 17600634, PMID: 39253917]. Phenolic acids present include caffeic, chlorogenic, p-coumaric, p-hydroxybenzoic, ferulic, gallic, protocatechuic, vanillic, salicylic, p-hydroxyphenylacetic, and ellagic acids [PMID: 22876612].

Mécanisme d'action

Extracts enriched in saponins and polyphenols have demonstrated the ability to dose-dependently inhibit the secretion of inflammatory mediators (IL-6, RANTES, MCP-1, PGE(2), and TNF-a) and matrix metalloproteinases (MMP-1, -3, -7, -8, -9, -13) in LPS-induced macrophage models [PMID: 21031629].

Preuves cliniques

Preuve BAcute post-viral cough in children

Some evidence from pediatric randomized controlled trials suggests efficacy for a multicomponent product containing Grindelia robusta, Plantago lanceolata, Helichrysum italicum, and honey [PMID: 33938204].

Preuve DInflammation

In vitro macrophage models showed anti-inflammatory properties by reducing LPS-induced inflammatory mediators [PMID: 21031629].

Preuve DBrain disorders (Alzheimer's and depression)

Extracts displayed strong in vitro scavenging activity against oxygen and nitrogen reactive species and monoamine oxidase-A (MAO-A) inhibitory activity [PMID: 24603350].

Sécurité et effets indésirables

In vitro tests on SH-SY5Y human neuroblastoma cells showed anti-MAO-A capacity at non-toxic concentrations [PMID: 24603350].

Synthèse des preuves

The evidence is primarily based on in vitro pharmacological studies and limited pediatric clinical trials for cough; overall clinical evidence for systemic use is low.

Sources PubMed

1.PMID: 37825252 (1881) — Grindelia Robusta in Asthma. · The Independent practitioner
2.PMID: 39454950 (2024) — The crystal structure of Grindelia robusta 7,13-copalyl diphosphate synthase reveals active site features controlling catalytic specificity. · The Journal of biological chemistry
3.PMID: 24603350 (2014) — HPLC-DAD-ESI/MS(n) analysis of phenolic compounds for quality control of Grindelia robusta Nutt. and bioactivities. · Journal of pharmaceutical and biomedical analysis
4.PMID: 17770060 (1984) — New crops for arid lands. · Science (New York, N.Y.)
5.PMID: 9691479 (1998) — Maxillary palps can mediate taste rejection of plant allelochemicals by caterpillars. · Journal of comparative physiology. A, Sensory, neural, and behavioral physiology

Grindelia

Sources et citations

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