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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Jujube (Ziziphus jujuba Mill.) is a nutritious fruit and medicinal herb used worldwide for its diverse biological effects, including antioxidant, anti-inflammatory, and neuroprotective properties [PMID:34128368, PMID:39409594].
Contexte
Ziziphus jujuba Mill. is a tree species widely cultivated in tropical and temperate zones, particularly in China [PMID:34128368, PMID:39409594]. Every part of the plant, including the leaves, fruits, and seeds, demonstrates therapeutic properties [PMID:39409594].
Usages traditionnels
Traditionally used in Eastern medicine for respiratory diseases (asthma, cough, laryngitis), gastrointestinal problems (constipation, colitis, liver diseases), and cardiovascular or genitourinary diseases [PMID:31670624]. In China, it is used to treat blood deficiency [PMID:33324222] and children with typhoid fever, furuncle, and ecthyma [PMID:28084039]. The seeds (Suan Zao Ren) are commonly used for insomnia [PMID:28084039, PMID:36720435].
Composés actifs
Bioactive components include polysaccharides, polyphenols, flavonoids, saponins, alkaloids, amino acids, nucleotides, fatty acids, and vitamin C [PMID:34128368, PMID:39065014, PMID:39679366]. Specific active metabolites include spinosin (from seeds), lupeol, and betulinic acid [PMID:36193419, PMID:39354208].
Mécanisme d'action
Jujube components may enhance glucose uptake via PI3K/Akt signaling, modulate AMPK activity, and regulate insulin signaling proteins [PMID:39354208]. Polyphenol extracts may inhibit NLRP3 and MAPKs signaling pathways to regulate gut microbiota homeostasis [PMID:38600887]. Seed metabolites modulate GABAergic activity and the serotonergic system [PMID:28899507].
Preuves cliniques
Preuve ADepression
Gan Mai Da Zao (GMDZ) decoction, containing jujube, showed mixed results in RCTs; some failed to show favorable effects on response rates in major depression, while others showed benefit in post-surgical depression [PMID:25262476].
Preuve AMenopausal Symptoms
A formula of licorice and jujube may improve sleep symptoms, but there is insufficient evidence for clinical recommendations [PMID:34237667].
Preuve CInsomnia
Ziziphus jujuba var. spinosa seeds are used as a phytomedicine for insomnia and have sedative and sleeping effects [PMID:28084039, PMID:36720435].
Synthèse des preuves
Evidence is primarily based on review articles and animal models (C and D levels). Systematic reviews of clinical trials for depression and menopause show insufficient or mixed evidence to support strong clinical recommendations (A level).
Sources PubMed
1.PMID: 34128368 (2021) — Research advances in bioactive components and health benefits of jujube (Ziziphus jujuba Mill.) fruit. · Journal of Zhejiang University. Science. B
2.PMID: 40580692 (2025) — Gan-Mai-Da-Zao decoction ameliorates depressive-like behaviors in CUMS mice via the microbiota-metabolism-inflammation axis. · Phytomedicine : international journal of phytotherapy and phytopharmacology
3.PMID: 22414105 (2012) — Nature against depression. · Current medicinal chemistry
4.PMID: 39065014 (2024) — Functional Nutrients and Jujube-Based Processed Products in Ziziphus jujuba. · Molecules (Basel, Switzerland)
5.PMID: 39679366 (2024) — Phytochemical, pharmacological, pharmacokinetic and toxicological characteristics of Ziziphi Spinosae Semen: a review.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
8.PMID: 39409594 (2024) — Ziziphus jujuba: Applications in the Pharmacy and Food Industry. · Plants (Basel, Switzerland)
9.PMID: 26392706 (2015) — "Ziziphus jujuba": A red fruit with promising anticancer activities. · Pharmacognosy reviews
10.PMID: 36720435 (2023) — Research progress of quality control for the seed of Ziziphus jujuba var. spinosa (Bunge) Hu ex H.F. Chow (Suan-Zao-Ren) and its proprietary Chinese medicines. · Journal of ethnopharmacology
11.PMID: 33763543 (2021) — Chloroplast genome sequence of the wild Ziziphus jujuba Mill. var. spinosa from North China. · Mitochondrial DNA. Part B, Resources
12.PMID: 39354208 (2024) — Ziziphus jujuba (Jujube) in Metabolic Syndrome: From Traditional Medicine to Scientific Validation. · Current nutrition reports
13.PMID: 35731918 (2022) — Wild Jujube (Ziziphus jujuba var. spinosa): A Review of Its Phytonutrients, Health Benefits, Metabolism, and Applications. · Journal of agricultural and food chemistry
14.PMID: 38600887 (2024) — Polyphenol Extracts from Ziziphus jujuba Mill. "Junzao" Attenuates Ulcerative Colitis by Inhibiting the NLRP3 and MAPKs Signaling Pathways and Regulating Gut Microbiota Homeostasis in Mice. · Molecular nutrition & food research
15.PMID: 33324222 (2020) — A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence. · Frontiers in pharmacology
16.PMID: 28680447 (2017) — A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection. · Evidence-based complementary and alternative medicine : eCAM
17.PMID: 36193419 (2022) — The pharmacology, pharmacokinetics, and toxicity of spinosin: A mini review. · Frontiers in pharmacology
18.PMID: 28274443 (2017) — Isolation, structures and bioactivities of the polysaccharides from jujube fruit (Ziziphus jujuba Mill.): A review. · Food chemistry
19.PMID: 28899507 (2017) — Ziziphus spinosa seeds for insomnia: A review of chemistry and psychopharmacology. · Phytomedicine : international journal of phytotherapy and phytopharmacology
20.PMID: 40308264 (2025) — Research progress on extraction, separation, structure, and biological activities of polysaccharides from jujube fruit (Ziziphus jujuba Mill.): a review. · Frontiers in chemistry
21.PMID: 29086878 (2017) — Steam distillation/drop-by-drop extraction with gas chromatography-mass spectrometry for fast determination of volatile components in jujube (Ziziphus jujuba Mill.) extract. · Chemistry Central journal
22.PMID: 31670624 (2020) — Therapeutic Effects of Ziziphus jujuba Mill. Fruit in Traditional and Modern Medicine: A Review. · Medicinal chemistry (Shariqah (United Arab Emirates))
23.PMID: 34237667 (2021) — Licorice (Glycyrrhiza spp.) and jujube (Ziziphus jujuba Mill.) formula for menopausal symptoms: Classical records, clinical evidence and experimental data. · Complementary therapies in clinical practice
24.PMID: 35161241 (2022) — Major Plant in Herbal Mixture Gan-Mai-Da-Zao for the Alleviation of Depression in Rat Models. · Plants (Basel, Switzerland)
25.PMID: 25262476 (2014) — Herbal medicine (Gan Mai Da Zao decoction) for depression: a systematic review and meta-analysis of randomized controlled trials. · Maturitas
26.PMID: 35627028 (2022) — Development of Functional Pizza Base Enriched with Jujube (Ziziphus jujuba) Powder. · Foods (Basel, Switzerland)
27.PMID: 28392956 (2017) — Effects of Herbal Medicine (Gan Mai Da Zao Decoction) on Several Types of Neuropsychiatric Disorders in an Animal Model: A Systematic Review: Herbal medicine for animal studies of neuropsychiatric diseases. · Journal of pharmacopuncture
28.PMID: 37446967 (2023) — Genotyping of Jujube (Ziziphus spp.) Germplasm in New Mexico and Southwestern Texas. · Plants (Basel, Switzerland)