Juniperus oxycedrus (Juniperus oxycedrus): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does cade oil work for psoriasis and eczema?

Cade oil contains active compounds including cadinene, guaiacol, phenols, and terpenes that contribute to its therapeutic effects. These constituents demonstrate antiseptic and anti-inflammatory properties when applied topically. The phenolic compounds, particularly guaiacol, provide antimicrobial activity against skin pathogens, while the terpenes help reduce inflammation and promote skin healing. This mechanism supports its traditional use for chronic inflammatory skin conditions. Evidence level: C.

Does cade oil interact with any medications?

There are no well-documented drug interactions for topical cade oil in current medical literature. However, because cade oil is applied to the skin, it may theoretically affect the absorption or efficacy of other topical medications applied to the same area. Patients using prescription topical treatments for psoriasis or eczema should consult a healthcare provider before adding cade oil to their regimen. Internal use is toxic and should be strictly avoided. Evidence level: C.

What is the recommended dosage for cade oil?

Cade oil should always be used in diluted form for topical application. The standard recommended concentration is 5-10% cade oil in a prepared formulation, such as a cream, ointment, or carrier oil blend. Undiluted cade oil is a strong irritant and should never be applied directly to the skin. Proper dilution is essential for safe and effective use. Evidence level: C.

Is cade oil safe to use during pregnancy?

Cade oil is considered unsafe during pregnancy and should be avoided. The phenolic compounds and other active constituents may pose risks to fetal development. Additionally, the potential for skin sensitization and systemic absorption through topical application raises safety concerns for pregnant individuals. Women who are breastfeeding should also avoid cade oil. Consult a qualified healthcare provider for alternative treatments for skin conditions during pregnancy.

What are the side effects of cade oil?

Cade oil can cause skin irritation and sensitization, particularly when used undiluted or applied to sensitive skin. Common reactions include redness, itching, burning sensations, and contact dermatitis. Some individuals may develop allergic sensitization with repeated use. Internal consumption of cade oil is toxic and can cause serious health effects including kidney damage. Always perform a patch test before widespread application and discontinue use if irritation occurs. Evidence level: C.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Juniperus oxycedrus is a Cupressaceae species used in traditional medicine for conditions such as diabetes and diarrhea [PMID:38777767, 22326357], though its pollen is a known allergen [PMID:24314710, 9648702].

Contexte

Juniperus oxycedrus, also known as prickly juniper, is a tree widespread in the Mediterranean and interior Anatolian and Mediterranean uplands [PMID:41829773, 42095825]. It belongs to the Cupressaceae family and has various subspecies, including subsp. oxycedrus, subsp. macrocarpa, and subsp. rufescens [PMID:23603383, 21999482, 28554036].

Usages traditionnels

It has been used in traditional medicine as an antidiarrheal medication [PMID:38777767] and in Turkey, decoctions of leaves and berries are used internally to lower blood glucose levels [PMID:22326357, 22063725, 21073939]. Cade oil is also used in traditional medicine in Morocco [PMID:40828635].

Composés actifs

Active compounds include the diterpene Sugiol [PMID:21202151], shikimic acid, 4-O-β-d-glucopyranosyl ferulic acid, and oleuropeic acid-8-O-β-d-glucopyranoside [PMID:22063725]. Essential oil constituents vary by part and subspecies but include α-pinene, limonene, manoyl oxide, germacrene D, and β-pinene [PMID:31696737, 35456809, 38690641]. Phenolic compounds such as apigenin, (-)-epicatechin, and luteolin have been identified in extracts [PMID:35448753].

Mécanisme d'action

In rodent jejunum models, aqueous extracts diminished maximum tone induced by low K+ [PMID:38777767]. Cade oil has demonstrated antioxidant capabilities through radical scavenging (DPPH, ABTS, and Galvinoxyl) and reducing abilities [PMID:39097895].

Preuves cliniques

Preuve DDiabetes/Hyperglycemia

Leaf and fruit extracts decreased blood glucose levels and lipid peroxidation in liver and kidney tissues in streptozotocin-induced diabetic rats [PMID:21073939]; subfractions of leaf extracts showed antidiabetic activity in vivo [PMID:22326357].

Preuve DDiarrhea/Bowel Spasms

Aqueous extract showed antispasmodic effects in rat jejunum and antidiarrheic activity in mice using castor oil models [PMID:38777767].

Preuve DAllergic Asthma

Cade oil exhibited antioxidant and anti-inflammatory effects in a Wistar allergic asthma model [PMID:39097895].

Preuve DWound Infection

Essential oil-loaded microneedles improved wound healing in rats infected with P. aeruginosa, S. aureus, and C. albicans [PMID:38256874].

Preuve DCypress Pollinosis

J. oxycedrus pollen is allergenic and shows wide cross-reactivity with other Cupressaceae species [PMID:9648702, 42095825].

Sécurité et effets indésirables

Ingestion of home-made extract (cade oil) has caused fever, severe hypotension, renal failure, hepatotoxicity, and severe cutaneous burns [PMID:15732446]. Fatal cases of cade oil poisoning have been reported in infants following topical application to treat diarrhea, vomiting, and fever, with phenol identified as the primary toxic component [PMID:40828635].

Synthèse des preuves

The evidence consists primarily of in vitro studies, animal models (rats/mice), and case reports of toxicity. There are no human clinical trials (RCTs) provided in the abstracts.

Sources PubMed

1.PMID: 21202151 (2008) — 6-Hydr-oxy-7-isopropyl-1,1,4a-trimethyl-2,3,4,4a,10,10a-hexa-hydro-phenanthren-9(1H)-one. · Acta crystallographica. Section E, Structure reports online
2.PMID: 24314710 (2013) — [Cypress pollen allergy]. · Revue des maladies respiratoires
3.PMID: 38777767 (2024) — Antispasmodic and antidiarrheal effects of Juniperus oxycedrus L. on the jejunum in rodents. · Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi
4.PMID: 11558640 (2001) — Final report on the safety assessment of Juniperus communis Extract, Juniperus oxycedrus Extract, Juniperus oxycedrus Tar, Juniperus phoenicea extract, and Juniperus virginiana Extract. · International journal of toxicology
5.PMID: 39097895 (2024) — Exploring the In Vitro and In Vivo Therapeutic Efficacy of Juniperus oxycedrus Cade Oil: Antioxidant, Anti-inflammatory, and Anti-asthmatic Effects in an Allergic Asthma Model.

Juniperus oxycedrus

Sources et citations

Calculer une dose sûre de Juniperus oxycedrus