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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Solanum aviculare
An Australasian plant valued for its steroidal alkaloid content used in pharmaceutical synthesis.
Kangaroo Apple (Solanum aviculare) is an Australasian shrub valued for its steroidal alkaloid content, primarily solasodine, which serves as a precursor for pharmaceutical steroid synthesis. Modern research explores its anticancer and anti-inflammatory potential, while traditional use focuses on topical applications for skin conditions and joint pain. The plant is considered toxic if ingested and is not recommended for internal use.
The primary active compounds, solasodine and its glycosides (solamargine, solasonine), exhibit cytotoxic effects by inducing apoptosis via caspase activation and mitochondrial membrane depolarization. They also inhibit NF-κB signaling, reducing pro-inflammatory cytokine production, and may interfere with microtubule polymerization, similar to colchicine. Additionally, solasodine acts as a precursor for the synthesis of steroidal hormones, including progesterone and corticosteroids, through microbial or enzymatic conversion.
An Australasian plant valued for its steroidal alkaloid content used in pharmaceutical synthesis.
Kangaroo Apple (Solanum aviculare) is an Australasian shrub valued for its steroidal alkaloid content, primarily solasodine, which serves as a precursor for pharmaceutical steroid synthesis. Modern research explores its anticancer and anti-inflammatory potential, while traditional use focuses on topical applications for skin conditions and joint pain. The plant is considered toxic if ingested and is not recommended for internal use.
The primary active compounds, solasodine and its glycosides (solamargine, solasonine), exhibit cytotoxic effects by inducing apoptosis via caspase activation and mitochondrial membrane depolarization. They also inhibit NF-κB signaling, reducing pro-inflammatory cytokine production, and may interfere with microtubule polymerization, similar to colchicine. Additionally, solasodine acts as a precursor for the synthesis of steroidal hormones, including progesterone and corticosteroids, through microbial or enzymatic conversion.