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KA
Not CommonRésumée par IA
Korean Acanthopanax
Acanthopanax senticosus
Tonique adaptogène dans la médecine Hanbang coréenne
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Acanthopanax senticosus (also known as Eleutherococcus senticosus or Siberian ginseng) is an adaptogenic plant native to Northeast Asia used to enhance stress resistance and immune function [PMID:40572479, PMID:31388349].
Contexte
Acanthopanax senticosus (Rupr.&Maxim.) Harms, belonging to the Araliaceae family, is a medicinal herb commonly known as Siberian ginseng or Ciwujia [PMID:40409102, PMID:21434569, PMID:30678313]. It is native to Northeast Asia and utilized in traditional Chinese, Korean, and Japanese medicine [PMID:40572479].
Usages traditionnels
Traditional applications include the treatment of inflammation, fatigue, and cancer [PMID:31388349]. In Traditional Chinese Medicine, it is used to invigorate qi, strengthen the spleen, nourish the kidney, invigorate the liver, replenish vitality, strengthen bones, stimulate appetite, and improve memory [PMID:21434569, PMID:33212178].
Composés actifs
Bioactive compounds include eleutherosides (specifically eleutheroside B/syringin and eleutheroside E/syringaresinol), lignans, saponins (such as Ciwujianoside C and Eleutheroside A), flavonoids, polysaccharides, coumarins, and phytosterols [PMID:40572479, PMID:30000865, PMID:21434569, PMID:41317222, PMID:40409102].
Mécanisme d'action
Mechanisms include the inhibition of PI3K/AKT1/mTOR-mediated glycolysis in myeloid-derived suppressor cells (MDSCs) to alleviate immunosuppression in gastric cancer [PMID:40409102], inhibition of JAK2/STAT3 signaling to protect bone marrow mesenchymal stem cells from high glucose-induced injury [PMID:40033807], and suppression of ferroptosis via the NNAT/NF-κB pathway to protect against cerebral ischemia-reperfusion injury [PMID:41317222]. It may also regulate autophagic flux via the AMPK/mTOR pathway [PMID:39307910].
Preuves cliniques
Preuve CGeneral Adaptogenic Use
Used to increase endurance, improve memory, and boost immunity, although no good human evidence supports these uses [PMID:30000865].
Preuve DImmune Response
Polysaccharides from A. senticosus induce interferon production [PMID:23531136] and stimulate macrophages, antibody formation, and T lymphocyte proliferation [PMID:1841992].
Preuve DNeuroprotection
Extracts improved learning and memory ability in Co-γ ray-irradiated mice by modulating neurotransmitters and gut microbiota [PMID:36971202].
Sécurité et effets indésirables
Generally well tolerated [PMID:30000865]. Reported adverse effects include breast tenderness, and it may increase blood pressure, bleeding, and blood sugar [PMID:30000865]. It has been identified in reports of herbal TCM-induced liver injury (hepatotoxicity) [PMID:26357619].
Grossesse et allaitement
No data exist on the safety and efficacy of eleuthero in nursing mothers or infants [PMID:30000865].
Synthèse des preuves
The evidence consists primarily of review articles and in vitro or animal studies (Level C and D). There is a noted lack of high-quality human clinical evidence to support its traditional uses as an adaptogen [PMID:30000865].
Sources PubMed
1.PMID: 40572479 (2025) — Eleutherococcus senticosus (Acanthopanax senticosus): An Important Adaptogenic Plant. · Molecules (Basel, Switzerland)
2.PMID: 30000865 (2006) — Acanthopanax senticosus: Photochemistry and Anticancer Potential. · The American journal of Chinese medicine
3.PMID: 40409102 (2025) — Eleutheroside A inhibits PI3K/AKT1/mTOR-mediated glycolysis in MDSCs to alleviate their immunosuppressive function in gastric cancer. · International immunopharmacology
4.PMID: 40033807 (2024) — Syringin protects high glucose-induced BMSC injury, cell senescence, and osteoporosis by inhibiting JAK2/STAT3 signaling. · Journal of applied biomedicine
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Traditional Chinese Medicine Induced Liver Injury.
· Journal of clinical and translational hepatology
6.PMID: 30678313 (2019) — The Chemical Characterization of Eleutherococcus senticosus and Ci-wu-jia Tea using UHPLC-UV-QTOF/MS. · International journal of molecular sciences
7.PMID: 31388349 (2019) — A review on the immunomodulatory activity of Acanthopanax senticosus and its active components. · Chinese medicine
8.PMID: 39307910 (2024) — Eleutheroside B Pretreatment Attenuates Hypobaric Hypoxia-Induced High-Altitude Pulmonary Edema by Regulating Autophagic Flux via the AMPK/mTOR Pathway. · Phytotherapy research : PTR
9.PMID: 21434569 (2011) — Acanthopanax senticosus: review of botany, chemistry and pharmacology. · Die Pharmazie
10.PMID: 41317222 (2025) — Ciwujianoside C Attenuates Cerebral Ischemia-Reperfusion Injury by Suppressing Ferroptosis via NNAT-Mediated Inhibition of NF-κB Signaling. · Neurochemical research
11.PMID: 23531136 (2000) — Immunomodulating components from chinese medicines. · Pharmaceutical biology
12.PMID: 1841992 (1991) — Immunomodulating Chinese herbal medicines. · Memorias do Instituto Oswaldo Cruz
13.PMID: 33212178 (2021) — A review of Acanthopanax senticosus (Rupr and Maxim.) harms: From ethnopharmacological use to modern application. · Journal of ethnopharmacology
14.PMID: 36971202 (2023) — Acanthopanax senticosus extract alleviates radiation-induced learning and memory impairment based on neurotransmitter-gut microbiota communication. · CNS neuroscience & therapeutics