Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
KA
Not CommonRésumée par IA
Korean Acanthopanax
Acanthopanax senticosus
Tonique adaptogène dans la médecine Hanbang coréenne
How does Korean Acanthopanax work as an adaptogen?
Korean Acanthopanax contains active compounds called eleutherosides, syringin, and lignans that modulate the hypothalamic-pituitary-adrenal (HPA) axis. These compounds help regulate the body's stress response by influencing cortisol production and supporting adrenal function. Research suggests the herb may also enhance immune cell activity and improve cellular energy metabolism through mitochondrial support. This dual action on stress hormones and immune function underlies its adaptogenic properties, helping the body resist physical, mental, and environmental stressors. Evidence level: C.
Does Korean Acanthopanax interact with any medications?
Korean Acanthopanax may interact with several medication classes. It can potentially enhance the effects of anticoagulant and antiplatelet medications, increasing bleeding risk. The herb may interact with immunosuppressants due to its immunomodulatory properties, potentially reducing their effectiveness. Because it affects cortisol and adrenal function, it may also interfere with hormone therapies, corticosteroid medications, and digoxin. Patients taking blood thinners, immunosuppressants, or hormone-related medications should consult a healthcare provider before use. Evidence level: C.
What is the recommended dosage for Korean Acanthopanax?
The typical adult dosage for Korean Acanthopanax is 300-600mg of standardized extract daily, or 3-5ml of tincture taken once or twice daily. For optimal results, herbalists often recommend taking the herb for 4-6 weeks followed by a 1-2 week break to prevent tolerance. Taking doses earlier in the day is advisable, as late administration may cause insomnia in some individuals. Dosage should be adjusted based on individual response and under guidance from a qualified practitioner. Evidence level: C, Traditional.
Is Korean Acanthopanax safe during pregnancy and breastfeeding?
Korean Acanthopanax is considered unsafe during pregnancy and should be avoided. The herb contains compounds that may stimulate uterine contractions and affect hormone levels, potentially posing risks to fetal development. There is insufficient safety data for breastfeeding, so use is not recommended while nursing. Women who are pregnant, planning to become pregnant, or breastfeeding should consult a qualified healthcare provider before using this or any herbal supplement. Evidence level: D.
What are the side effects of Korean Acanthopanax?
Korean Acanthopanax is generally well-tolerated, but some individuals may experience side effects. The most common include insomnia when taken late in the day and mild gastrointestinal upset such as nausea or diarrhea. Headaches and irritability have been reported in some cases. Those with hormone-sensitive cancers or autoimmune diseases should avoid this herb due to its immunomodulatory and potential hormone-affecting properties. Discontinue use if adverse effects occur and consult a healthcare provider. Evidence level: C, Traditional.
What is Korean Acanthopanax used for in traditional medicine?
In Korean Hanbang medicine, Acanthopanax senticosus has been used for centuries as a restorative tonic to strengthen vital energy, combat fatigue, and help the body adapt to stress. Traditionally, it was prescribed for convalescence after illness, general weakness, and immune support during winter months. Modern herbalists continue to use it for stress-related fatigue, immune enhancement, and as a general adaptogen to improve physical and mental resilience. Evidence level: Traditional, C.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Acanthopanax senticosus (also known as Eleutherococcus senticosus or Siberian ginseng) is an adaptogenic plant native to Northeast Asia used to enhance stress resistance and immune function [PMID:40572479, PMID:31388349].
Contexte
Acanthopanax senticosus (Rupr.&Maxim.) Harms, belonging to the Araliaceae family, is a medicinal herb commonly known as Siberian ginseng or Ciwujia [PMID:40409102, PMID:21434569, PMID:30678313]. It is native to Northeast Asia and utilized in traditional Chinese, Korean, and Japanese medicine [PMID:40572479].
Usages traditionnels
Traditional applications include the treatment of inflammation, fatigue, and cancer [PMID:31388349]. In Traditional Chinese Medicine, it is used to invigorate qi, strengthen the spleen, nourish the kidney, invigorate the liver, replenish vitality, strengthen bones, stimulate appetite, and improve memory [PMID:21434569, PMID:33212178].
Composés actifs
Bioactive compounds include eleutherosides (specifically eleutheroside B/syringin and eleutheroside E/syringaresinol), lignans, saponins (such as Ciwujianoside C and Eleutheroside A), flavonoids, polysaccharides, coumarins, and phytosterols [PMID:40572479, PMID:30000865, PMID:21434569, PMID:41317222, PMID:40409102].
Mécanisme d'action
Mechanisms include the inhibition of PI3K/AKT1/mTOR-mediated glycolysis in myeloid-derived suppressor cells (MDSCs) to alleviate immunosuppression in gastric cancer [PMID:40409102], inhibition of JAK2/STAT3 signaling to protect bone marrow mesenchymal stem cells from high glucose-induced injury [PMID:40033807], and suppression of ferroptosis via the NNAT/NF-κB pathway to protect against cerebral ischemia-reperfusion injury [PMID:41317222]. It may also regulate autophagic flux via the AMPK/mTOR pathway [PMID:39307910].
Preuves cliniques
Preuve CGeneral Adaptogenic Use
Used to increase endurance, improve memory, and boost immunity, although no good human evidence supports these uses [PMID:30000865].
Preuve DImmune Response
Polysaccharides from A. senticosus induce interferon production [PMID:23531136] and stimulate macrophages, antibody formation, and T lymphocyte proliferation [PMID:1841992].
Preuve DNeuroprotection
Extracts improved learning and memory ability in Co-γ ray-irradiated mice by modulating neurotransmitters and gut microbiota [PMID:36971202].
Sécurité et effets indésirables
Generally well tolerated [PMID:30000865]. Reported adverse effects include breast tenderness, and it may increase blood pressure, bleeding, and blood sugar [PMID:30000865]. It has been identified in reports of herbal TCM-induced liver injury (hepatotoxicity) [PMID:26357619].
Grossesse et allaitement
No data exist on the safety and efficacy of eleuthero in nursing mothers or infants [PMID:30000865].
Synthèse des preuves
The evidence consists primarily of review articles and in vitro or animal studies (Level C and D). There is a noted lack of high-quality human clinical evidence to support its traditional uses as an adaptogen [PMID:30000865].
Sources PubMed
1.PMID: 40572479 (2025) — Eleutherococcus senticosus (Acanthopanax senticosus): An Important Adaptogenic Plant. · Molecules (Basel, Switzerland)
2.PMID: 30000865 (2006) — Acanthopanax senticosus: Photochemistry and Anticancer Potential. · The American journal of Chinese medicine
3.PMID: 40409102 (2025) — Eleutheroside A inhibits PI3K/AKT1/mTOR-mediated glycolysis in MDSCs to alleviate their immunosuppressive function in gastric cancer. · International immunopharmacology
4.PMID: 40033807 (2024) — Syringin protects high glucose-induced BMSC injury, cell senescence, and osteoporosis by inhibiting JAK2/STAT3 signaling. · Journal of applied biomedicine
5.PMID: 26357619 (2014) — Traditional Chinese Medicine Induced Liver Injury. · Journal of clinical and translational hepatology
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 30678313 (2019) — The Chemical Characterization of Eleutherococcus senticosus and Ci-wu-jia Tea using UHPLC-UV-QTOF/MS. · International journal of molecular sciences
7.PMID: 31388349 (2019) — A review on the immunomodulatory activity of Acanthopanax senticosus and its active components. · Chinese medicine
8.PMID: 39307910 (2024) — Eleutheroside B Pretreatment Attenuates Hypobaric Hypoxia-Induced High-Altitude Pulmonary Edema by Regulating Autophagic Flux via the AMPK/mTOR Pathway. · Phytotherapy research : PTR
9.PMID: 21434569 (2011) — Acanthopanax senticosus: review of botany, chemistry and pharmacology. · Die Pharmazie
10.PMID: 41317222 (2025) — Ciwujianoside C Attenuates Cerebral Ischemia-Reperfusion Injury by Suppressing Ferroptosis via NNAT-Mediated Inhibition of NF-κB Signaling. · Neurochemical research
11.PMID: 23531136 (2000) — Immunomodulating components from chinese medicines. · Pharmaceutical biology
12.PMID: 1841992 (1991) — Immunomodulating Chinese herbal medicines. · Memorias do Instituto Oswaldo Cruz
13.PMID: 33212178 (2021) — A review of Acanthopanax senticosus (Rupr and Maxim.) harms: From ethnopharmacological use to modern application. · Journal of ethnopharmacology
14.PMID: 36971202 (2023) — Acanthopanax senticosus extract alleviates radiation-induced learning and memory impairment based on neurotransmitter-gut microbiota communication. · CNS neuroscience & therapeutics