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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Launaea taraxacifolia contains bioactive compounds including flavonoids, phenolics, sesquiterpene lactones, and tannins that contribute to its medicinal effects. These compounds demonstrate antioxidant and anti-inflammatory properties, which may explain its traditional use for inflammatory conditions and blood disorders. The flavonoids and phenolics help neutralize free radicals, while sesquiterpene lactones contribute to anti-inflammatory activity (Evidence Level C).
Does Launaea taraxacifolia interact with any medications?
There are no well-documented drug interactions for Launaea taraxacifolia in current scientific literature. However, due to limited clinical research, caution is advised when combining it with anticoagulant or antiplatelet medications, as the herb's potential effects on blood properties have not been fully studied. Patients taking prescription medications should consult a healthcare provider before adding this herb to their regimen (Evidence Level C).
What is the recommended dosage for Launaea taraxacifolia?
The traditional dosage for Launaea taraxacifolia is consuming fresh leaves freely as a vegetable in meals, or approximately 5 grams of dried leaves prepared as tea. As a food plant commonly eaten across West Africa, the fresh leaves can be incorporated into the diet without strict measurement. Standardized extracts are not widely available, so traditional preparations remain the primary form of consumption (Evidence Level C, Traditional).
Is Launaea taraxacifolia safe during pregnancy and breastfeeding?
Launaea taraxacifolia is generally considered safe during pregnancy and breastfeeding when consumed in normal dietary amounts. The herb has a long history of use as a leafy vegetable in West African cuisine without reported adverse effects. However, pregnant and breastfeeding women should avoid excessive consumption and consult a healthcare provider before using concentrated preparations or supplements (Evidence Level C, Traditional).
What are the health benefits of Launaea taraxacifolia?
Launaea taraxacifolia is traditionally used for blood disorders, inflammation, digestive issues, fever, and edema. The herb contains flavonoids, phenolics, and sesquiterpene lactones that provide antioxidant and anti-inflammatory support. In West African traditional medicine, it serves as a general tonic and blood purifier. While these uses are well-established in traditional practice, more clinical research is needed to confirm these effects (Evidence Level C, Traditional).
What are the side effects of Launaea taraxacifolia?
Launaea taraxacifolia is very well tolerated when consumed in normal amounts. Side effects are rare but may include allergic reactions in individuals sensitive to plants in the Asteraceae family. Excessive consumption could potentially cause digestive discomfort. Those with known allergies to daisies, ragweed, or related plants should exercise caution. No serious adverse effects have been documented in traditional use (Evidence Level C, Traditional).
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 17 articles PubMed · modèle : gemma4:31b
Résumé
Launaea taraxacifolia, also known as African lettuce, is a medicinal herb and vegetable primarily found in tropical Africa with demonstrated antioxidant and pharmacological activities [PMID:30147733, PMID:29456385].
Contexte
Launaea taraxacifolia (Asteraceae) is a leafy vegetable endemic to parts of southwest Nigeria and widely distributed across Africa, from Senegal in the west to Ethiopia, Tanzania, and Southern Africa [PMID:38827252, PMID:27631192]. It is sometimes classified as a weed in West and Central Africa and has been naturalized in Asia, North America, Europe, and North Africa [PMID:38827252].
Usages traditionnels
The plant is used in West Africa to manage cardiovascular, respiratory, haematological, endocrine, and metabolic diseases [PMID:30147733]. Specific traditional applications include the treatment of hypertension, anemia, diabetes, bleeding, dyslipidemia, and liver diseases [PMID:32544019, PMID:29456385]. It is also used by people in Western Africa to treat malaria and related symptoms [PMID:28050307].
Composés actifs
The essential oil of the leaves is dominated by monoterpene hydrocarbons (78.1%), including limonene (48.8%), sabinene (18.8%), and (E)-β-ocimene (4.6%), as well as oxygenated monoterpenoids (16.2%), sesquiterpene hydrocarbons (2.1%), oxygenated sesquiterpenoids (0.3%), and non-terpenoid derivatives (3.3%) [PMID:32664478].
Mécanisme d'action
The herb exhibits antioxidant activity through the scavenging of DPPH, nitric oxide (NO), and hydroxyl (OH) radicals, as well as metal chelating and anti-lipid peroxidation abilities [PMID:29456385]. In diabetic models, it ameliorates complications via antioxidant mechanisms, specifically affecting reduced glutathione (GSH), superoxide dismutase (SOD), and glutathione S-transferase (GST) activities [PMID:32812931]. It may also act as a galactagogue by stimulating hyperprolactinaemia [PMID:32010724].
Preuves cliniques
Preuve DDiabetes (Animal Model)
Leaf partitions reversed hyperglycemia within seven days and ameliorated pathophysiological complications via antioxidant mechanisms [PMID:32812931]
Methanolic extracts possess antiplasmodial activity against Plasmodium berghei in mice [PMID:28050307]
Preuve DCancer (In Vitro)
Crude aqueous extracts showed antiproliferative and apoptotic effects on WHC01 esophageal cancer cells [PMID:27631192]
Preuve DLactation (Animal Model)
n-hexane leaf fraction exhibited galactopoietic potential by increasing serum prolactin and oxytocin levels [PMID:32010724]
Sécurité et effets indésirables
In a 28-day subacute toxicity study in male Wistar rats, doses of 500 and 1000 mg/kg body weight showed no signs of toxicity, mortality, or treatment-related abnormalities in biochemical and hematological parameters [PMID:32544019]. A limit test dose of 5000 mg/kg also did not provoke death or toxicity signs [PMID:32544019].
Interactions médicamenteuses
L. taraxacifolia may have herb-drug interaction potential through the inhibition of drug-metabolizing enzymes CYP1A2, CYP2C9, and CYP2C19 [PMID:27631192].
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant antioxidant, antihypertensive, and anti-diabetic potential, with preliminary safety data in rats.
Sources PubMed
1.PMID: 30147733 (2018) — The Ethnopharmacological and Nutraceutical Relevance of Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey. · Evidence-based complementary and alternative medicine : eCAM
2.PMID: 27631192 (2016) — African Lettuce (Launaea taraxacifolia) Displays Possible Anticancer Effects and Herb-Drug Interaction Potential by CYP1A2, CYP2C9, and CYP2C19 Inhibition. · Omics : a journal of integrative biology
3.PMID: 29456385 (2018) — DNA Damage Protecting Activity and Antioxidant Potential of Launaea taraxacifolia Leaves Extract. · Journal of natural science, biology, and medicine
4.PMID: 32544019 (2020) — Toxicological Studies of Hydroethanolic Leaf Extract of Launaea taraxacifolia (Willd) Amin Ex C. Jeffrey on Wistar Rats. · Journal of medicinal food
5.PMID: 32812931 (2020) — Launaea taraxacifolia leaf partitions ameliorate alloxan-induced pathophysiological complications via antioxidant mechanisms in diabetic rats.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 38827252 (2024) — Dataset on evaluation of intra-specific genetic diversity and phylogenetic relationship of Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey in southwest Nigeria using rbcL gene maker. · Data in brief
7.PMID: 32664478 (2020) — Composition of the Essential Oil and Insecticidal Activity of Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey Growing in Nigeria. · Foods (Basel, Switzerland)
8.PMID: 36789818 (2022) — Antihypertensive action of Launaea taraxacifolia and its molecular mechanism of action. · Pakistan journal of pharmaceutical sciences
9.PMID: 33389949 (2020) — Phytobiological-facilitated Production of Silver Nanoparticles From Selected Non-cultivated Vegetables in Nigeria and Their Biological Potential. · Turkish journal of pharmaceutical sciences
10.PMID: 28471730 (2017) — A Vegetable, Launaea taraxacifolia, Mitigated Mercuric Chloride Alteration of the Microanatomy of Rat Brain. · Journal of dietary supplements
12.PMID: 34156587 (2021) — Influence of Crescentia cujete and Launaea taraxacifolia leaves on growth, immune indices, gut microbiota, blood chemistry, carcass, and meat quality in broiler chickens. · Tropical animal health and production
13.PMID: 29360627 (2018) — Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey inhibits oxidative damage and econucleotidase followed by increased cellular ATP in testicular cells of rats exposed to metropolitan polluted river water. · Journal of basic and clinical physiology and pharmacology
14.PMID: 24919929 (2015) — Cisplatin-induced testicular dysfunction and its amelioration by Launaea taraxacifolia leaf extract. · Andrologia
15.PMID: 32010724 (2019) — Effects of Launaea taraxacifolia and resveratrol on milk yield and serum prolactin and oxytocin levels: a lactogenic study. · International journal of veterinary science and medicine
16.PMID: 28050307 (2016) — Inhibition of In Vivo Growth of Plasmodium berghei by Launaea taraxacifolia and Amaranthus viridis in Mice. · Malaria research and treatment
17.PMID: 26891286 (2016) — Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings. · Molecules (Basel, Switzerland)