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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Amaranth (Amaranthus hybridus) is a climate-resilient, nutrient-dense pseudocereal and vegetable crop with potential antioxidant and pharmacological activities [PMID:35739986, PMID:35206094].
Background
Amaranthus hybridus, also known as slim amaranth or quelite, is a C4 photosynthetic herbaceous plant and agronomically important species [PMID:32835372, PMID:35739986]. It is considered a pseudo-cereal crop that is genetically diverse and phenotypically plastic [PMID:35551526, PMID:17511467].
Traditional uses
Amaranth species have been used by pre-Columbian cultures for 6,000 to 8,000 years [PMID:33101347] and are Andean staples in Colombia, Ecuador, Peru, Bolivia, northern Argentina, and Chile, where they have ethnopharmacological uses including anticancer applications [PMID:38139854].
Active compounds
A. hybridus leaves contain total flavonoids, total polyphenols, betalains, betaxanthins, and betacyanins [PMID:35739986]. Other bioactive compounds found in the genus include phenolic acids, carotenoids, alkaloids, terpenoids, saponins, peptides, squalene, tocopherols, and vitamins [PMID:38139854, PMID:40361686].
Mechanism of action
Amaranth storage proteins contain encrypted sequences that, when released, may inhibit enzymes of the Renin-Angiotensin-Aldosterone system, specifically Angiotensin Converting Enzyme (ACE) and Renin [PMID:33101 la347].
Amaranth may decrease total cholesterol and low-density lipoprotein cholesterol in animal models; it is reviewed as a potential adjunct to improve cardiovascular risk profiles [PMID:31757630, PMID:38603555].
Evidence DMalnutrition
In a mouse model, maize toast enriched with 10% Amaranthus hybridus (quelite) flour was evaluated for nutritional rehabilitation following food restriction [PMID:40971017].
Evidence DFungal Infections (In Vitro)
Leaf extracts of A. hybridus inhibited the growth of Fusarium equiseti, Rhizoctonia solani, and Trichoderma harzianum [PMID:37111946].
Evidence CDiabetes
Phytochemicals and extracts of amaranth are reported to have antidiabetic potential [PMID:38603555].
Safety & adverse effects
Amaranth contains antinutritional factors such as oxalates, which can lower calcium and magnesium availability and are potential risk factors for kidney stone development [PMID:17511467]. Other antinutrients mentioned include nitrates and saponins [PMID:41694082].
Evidence summary
The evidence is primarily based on in vitro studies, animal models, and literature reviews (Levels C and D). There is a lack of high-level human clinical trial data (Level B) or meta-analyses (Level A) in the provided set.
PubMed sources
1.PMID: 24254720 (1992) — Allelopathy ofSasa cernua. · Journal of chemical ecology
2.PMID: 32835372 (2020) — Draft Genomes of Amaranthus tuberculatus, Amaranthus hybridus, and Amaranthus palmeri. · Genome biology and evolution
3.PMID: 33101347 (2020) — Amaranth as a Source of Antihypertensive Peptides. · Frontiers in plant science
4.PMID: 17511467 (2007) — Oxalate in grain amaranth. · Journal of agricultural and food chemistry
5.PMID: 25831476 (2017) — Structures, physicochemical properties, and applications of amaranth starch. · Critical reviews in food science and nutrition
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 37111946 (2023) — Antifungal Potency of Amaranth Leaf Extract: An In Vitro Study. · Plants (Basel, Switzerland)
7.PMID: 35739986 (2022) — Characterization of Phytochemicals, Nutrients, and Antiradical Potential in Slim Amaranth. · Antioxidants (Basel, Switzerland)
8.PMID: 31757630 (2019) — Amaranth as a potential dietary adjunct of lifestyle modification to improve cardiovascular risk profile. · Nutrition research (New York, N.Y.)
9.PMID: 32430681 (2020) — Agrobacterium rhizogenes-mediated transformation of grain (Amaranthus hypochondriacus) and leafy (A. hybridus) amaranths. · Plant cell reports
10.PMID: 35206094 (2022) — The Dual Nature of Amaranth-Functional Food and Potential Medicine. · Foods (Basel, Switzerland)
11.PMID: 38139854 (2023) — Chenopodium quinoa Willd. and Amaranthus hybridus L.: Ancestral Andean Food Security and Modern Anticancer and Antimicrobial Activity. · Pharmaceuticals (Basel, Switzerland)
12.PMID: 35108086 (2022) — Internalization of Salmonella in Leafy Greens and Impact on Acid Tolerance. · Applied and environmental microbiology
13.PMID: 28477232 (2018) — Cytogenetic characterization of Amaranthus caudatus L. and Amaranthus hybridus subsp. cruentus (L.) Thell. · Cytotechnology
14.PMID: 40971017 (2025) — Maize Toast Enriched with Quelite Flour (Amaranthus hybridus) as an Alternative for Malnutrition in a Mouse Model. · Plant foods for human nutrition (Dordrecht, Netherlands)
15.PMID: 38603555 (2024) — Therapeutic Effects of Amaranth: Analysis of the Antidiabetic Potential of the Plant. · Journal of medicinal food
16.PMID: 36835680 (2023) — A Review of Insect Pest Management in Vegetable Crop Production in Nigeria. · Insects
17.PMID: 35852982 (2022) — [Amaranth grain proteins: prospects for use in specialized food products]. · Voprosy pitaniia
18.PMID: 35161392 (2022) — Identification of Weed-Suppressive Tomato Cultivars for Weed Management. · Plants (Basel, Switzerland)
19.PMID: 40361686 (2025) — Prospects for the Use of Amaranth Grain in the Production of Functional and Specialized Food Products. · Foods (Basel, Switzerland)
20.PMID: 30307006 (2018) — Emerging opportunities in exploring the nutritional/functional value of amaranth. · Food & function
21.PMID: 35551526 (2022) — Genetic diversity analysis and marker-trait associations in Amaranthus species. · PloS one
22.PMID: 38091781 (2024) — Amaranth proteins: From extraction to application as nanoparticle-based delivery systems for bioactive compounds. · Food chemistry
23.PMID: 38592842 (2024) — Genome-Wide Comparative Analysis of Five Amaranthaceae Species Reveals a Large Amount of Repeat Content. · Plants (Basel, Switzerland)
24.PMID: 37448872 (2023) — Amaranth Genomic Resource Database: an integrated database resource of Amaranth genes and genomics. · Frontiers in plant science
25.PMID: 31599971 (2019) — Effect of the Incorporation of Amaranth (Amaranthus Mantegazzianus) into Fat- and Cholesterol-Rich Diets for Wistar Rats. · Journal of food science
26.PMID: 39204636 (2024) — Amaranth Plants with Various Color Phenotypes Recruit Different Soil Microorganisms in the Rhizosphere. · Plants (Basel, Switzerland)
27.PMID: 42062397 (2026) — Ecological study on alien Amaranthus spinosus L. in the Egyptian Nile Valley. · Scientific reports
28.PMID: 41694082 (2026) — Amaranth as a sustainable feed resource for livestock. · Veterinary and animal science