PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Pre-treatment with isofuranodiene (10 mg/kg i.p.) reduced inflammatory cytokines and lipid peroxidation, leading to faster recovery and improved neurological severity scores [PMID:33918587]
Isofuranodiene stimulated neuritogenesis in rat neuronal PC-12 cells, particularly at concentrations of 12.5 and 25 μM [PMID:26304411]
Flower oil and isofuranodiene showed cytotoxic activity against HCT116 cells, inducing apoptosis [PMID:24924290]
Isofuranodiene synergizes with temozolomide to induce death in human GBM cell lines [PMID:30599912]
Essential oils and isofuranodiene effectively inhibited the growth of Trypanosoma brucei [PMID:28087440]
Evidence summary
PubMed sources
- 1.PMID: 11454342 (2001) — Sesquiterpene lactones from Smyrnium olusatrum. · Phytochemistry
- 2.PMID: 33918587 (2021) — Isofuranodiene, a Natural Sesquiterpene Isolated from Wild Celery (Smyrnium olusatrum L.), Protects Rats against Acute Ischemic Stroke. · Pharmaceuticals (Basel, Switzerland)
- 3.PMID: 26304411 (2016) — Isofuranodiene: A neuritogenic compound isolated from wild celery (Smyrnium olusatrum L., Apiaceae). · Food chemistry
- 4.PMID: 11711086 (1998) — Essential oil composition of smyrnium olusatrum. · Phytochemistry
- 5.PMID: 19508747 (2009) — Antileishmanial activity in Israeli plants. · Annals of tropical medicine and parasitology