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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Leonurus japonicus, known as Chinese motherwort, is a traditional medicinal herb widely used in Asia primarily for treating obstetrical and gynecological diseases [PMID:31195353, PMID:38195564].
Contexte
Leonurus japonicus Houtt. (Lamiaceae) is an herbaceous flowering plant native to Asia [PMID:24412548, PMID:38195564]. The aerial parts of the plant are typically used as the medicinal herb [PMID:35272128, PMID:39904422].
Usages traditionnels
It has been used for thousands of years in traditional Chinese medicine to treat menstrual and delivery disorders caused by blood stasis, including dysmenorrhea, amenorrhea, postpartum hemorrhage, lochia, and breast pain [PMID:31195353, PMID:24412548, PMID:29360539]. It is also traditionally used for diuresis, detumescence, and clearing heat [PMID:40540192, PMID:33300684].
Composés actifs
The herb contains over 280 chemical compounds [PMID:31195353, PMID:38195564]. Major bioactive components include alkaloids (specifically leonurine and stachydrine), diterpenes, and flavones [PMID:24412548, PMID:32113063]. Other identified compounds include glucaric acids and lignans [PMID:26526024, PMID:34390972].
Mécanisme d'action
Leonurine exhibits anti-oxidative stress, anti-inflammatory, anti-apoptotic, and anti-fibrotic properties [PMID:31069695, PMID:39409181]. Stachydrine acts as an angiogenic promoter and provides cardioprotection by inhibiting ECM deposition and decreasing inflammatory stress via pathways such as NF-κB and JAK/STAT [PMID:36940619, PMID:32173585]. In the liver, leonurine may ameliorate NAFLD via the ADRA1a/AMPK/SCD1 axis [PMID:39409181].
Preuves cliniques
Preuve APostpartum Hemorrhage (PPH)
Motherwort injection combined with oxytocin is used for PPH prevention [PMID:40527062]; a systematic review and meta-analysis of RCTs indicates benefits of motherwort injection for preventing post-abortion uterine hemorrhage [PMID:35935833].
Preuve CMenstrual Disorders
Widely used to treat menstrual disorders, including dysmenorrhea and amenorrhea [PMID:33017723, PMID:31195353].
Preuve CCardiovascular and CNS Diseases
Leonurine and stachydrine are identified as potential agents for treating cardiovascular and central nervous system diseases due to anti-inflammatory and neuroprotective activities [PMID:36940619, PMID:33300684].
Sécurité et effets indésirables
While many components show low toxicity, motherwort essential oil was found to be toxic to zebrafish embryos even at low concentrations [PMID:29729400].
Grossesse et allaitement
Used traditionally and clinically for postpartum hemorrhage and delivery disorders [PMID:31195353, PMID:40527062].
Synthèse des preuves
Strong evidence (Meta-analyses) supports its use in preventing uterine hemorrhage. Moderate to low evidence (Reviews and animal/in vitro studies) supports its use for menstrual disorders, cardiovascular protection, and anti-inflammatory effects.
Sources PubMed
1.PMID: 36775079 (2023) — Jinfeng pills ameliorate premature ovarian insufficiency induced by cyclophosphamide in rats and correlate to modulating IL-17A/IL-6 axis and MEK/ERK signals. · Journal of ethnopharmacology
2.PMID: 40527062 (2025) — Motherwort synergized with oxytocin for postpartum hemorrhage prevention: Integrated clinical efficacy and mechanism exploration. · Phytomedicine : international journal of phytotherapy and phytopharmacology
3.PMID: 33017723 (2020) — Uncovering the pharmacological mechanism of motherwort (Leonurus japonicus Houtt.) for treating menstrual disorders: A systems pharmacology approach. · Computational biology and chemistry
4.PMID: 31195353 (2019) — Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: A comprehensive overview. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Leonurus japonicus Houtt.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine.
· Journal of ethnopharmacology
6.PMID: 38195564 (2024) — De novo chromosome-level genome assembly of Chinese motherwort (Leonurus japonicus). · Scientific data
7.PMID: 31069695 (2020) — Leonurine: From Gynecologic Medicine to Pleiotropic Agent. · Chinese journal of integrative medicine
8.PMID: 29729400 (2018) — Angiogenic effect of motherwort (Leonurus japonicus) alkaloids and toxicity of motherwort essential oil on zebrafish embryos. · Fitoterapia
9.PMID: 35272128 (2022) — Leonurus japonicus Houtt. (Motherwort): Systematic research through chemical profiling, stability under controlled conditions and pharmacokinetic analysis on screening Q-markers for quality control. · Journal of pharmaceutical and biomedical analysis
10.PMID: 35935833 (2022) — Motherwort Injection for Preventing Uterine Hemorrhage in Women With Induced Abortion: A Systematic Review and Meta-Analysis of Randomized Evidence. · Frontiers in pharmacology
11.PMID: 39904422 (2025) — Effect of Leonurus japonicus alkaloids on endometrial inflammation and its mechanisms. · Journal of ethnopharmacology
12.PMID: 40884938 (2025) — Enhancement of skin defense against UVB damage by fermentation of Leonurus japonicus with Saccharomyces cerevisiae. · Phytomedicine : international journal of phytotherapy and phytopharmacology
13.PMID: 40540192 (2025) — Research progress on molecular mechanism and future perspectives of leonurine. · Frontiers of medicine
14.PMID: 39409181 (2024) — Leonurine Inhibits Hepatic Lipid Synthesis to Ameliorate NAFLD via the ADRA1a/AMPK/SCD1 Axis. · International journal of molecular sciences
15.PMID: 39127116 (2024) — Jin-Xin-Kang alleviates heart failure by mitigating mitochondrial dysfunction through the Calcineurin/Dynamin-Related Protein 1 signaling pathway. · Journal of ethnopharmacology
16.PMID: 32173585 (2020) — A review of pharmacological and pharmacokinetic properties of stachydrine. · Pharmacological research
17.PMID: 36940619 (2023) — Stachydrine, a potential drug for the treatment of cardiovascular system and central nervous system diseases. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
19.PMID: 19330917 (2009) — Cytotoxicity of Chinese motherwort (YiMuCao) aqueous ethanol extract is non-apoptotic and estrogen receptor independent on human breast cancer cells. · Journal of ethnopharmacology
20.PMID: 35217209 (2022) — Leonurus japonicus Houttuyn induces reactive oxygen species-mediated apoptosis via regulation of miR-19a-3p/PTEN/PI3K/AKT in U937 and THP-1 cells. · Journal of ethnopharmacology
21.PMID: 37950440 (2024) — Multiomics analyses of two Leonurus species illuminate leonurine biosynthesis and its evolution. · Molecular plant
22.PMID: 41079267 (2025) — Leonurine Alleviates DSS-Induced Colitis in Mice by Regulating Pancreatic Secretion Pathway and Gut Microbiota. · Journal of immunology research
23.PMID: 34390972 (2021) — New lignans from the fruits of Leonurus japonicus and their hepatoprotective activities. · Bioorganic chemistry
25.PMID: 37066895 (2024) — Antioxidant and anti-melanogenesis activities of extracts from Leonurus japonicus Houtt. · Biotechnology & genetic engineering reviews
26.PMID: 38670420 (2024) — Novel insights into the protective effects of leonurine against acute kidney injury: Inhibition of ER stress-associated ferroptosis via regulating ATF4/CHOP/ACSL4 pathway. · Chemico-biological interactions
27.PMID: 39170783 (2024) — Exploring stachydrine: from natural occurrence to biological activities and metabolic pathways. · Frontiers in plant science
28.PMID: 29360539 (2018) — Discovery of Leonuri and therapeutical applications: From bench to bedside. · Pharmacology & therapeutics
29.PMID: 33300684 (2021) — Leonurine, a potential drug for the treatment of cardiovascular system and central nervous system diseases. · Brain and behavior
30.PMID: 970356 (1976) — A contribution to our knowledge of Leonurus L., i-mu-ts'ao, the Chinese motherwort. · The American journal of Chinese medicine