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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Homalanthus nutans
Samoan tree containing prostratin, studied for HIV research.
Mamala (Homalanthus nutans) is a Samoan tree traditionally used for hepatitis, yellow fever, and skin conditions. Modern research focuses on its diterpene prostratin, a non-tumor-promoting phorbol ester that reactivates latent HIV reservoirs, making it a candidate for HIV eradication strategies. Its anti-inflammatory properties are also under investigation.
Prostratin activates protein kinase C (PKC) isoforms, particularly PKCδ and PKCε, leading to NF-κB activation and subsequent transcription of HIV genes from latent proviral DNA. This reactivation exposes infected cells to immune clearance. Additionally, prostratin inhibits phorbol ester-induced tumor promotion by downregulating PKC activity over time and may modulate inflammatory pathways via COX-2 inhibition.
Samoan tree containing prostratin, studied for HIV research.
Mamala (Homalanthus nutans) is a Samoan tree traditionally used for hepatitis, yellow fever, and skin conditions. Modern research focuses on its diterpene prostratin, a non-tumor-promoting phorbol ester that reactivates latent HIV reservoirs, making it a candidate for HIV eradication strategies. Its anti-inflammatory properties are also under investigation.
Prostratin activates protein kinase C (PKC) isoforms, particularly PKCδ and PKCε, leading to NF-κB activation and subsequent transcription of HIV genes from latent proviral DNA. This reactivation exposes infected cells to immune clearance. Additionally, prostratin inhibits phorbol ester-induced tumor promotion by downregulating PKC activity over time and may modulate inflammatory pathways via COX-2 inhibition.