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Siraitia grosvenorii
A Chinese gourd whose mogrosides are 150-300x sweeter than sugar with zero calories, used in TCM for coughs and longevity.
Monk fruit (Siraitia grosvenorii) is a Chinese gourd whose mogrosides, particularly mogroside V, provide a zero-calorie sweetness 150–300 times that of sucrose. Traditionally used in TCM for cough, sore throat, and as a longevity tonic, modern research indicates antioxidant, anti-inflammatory, and anti-diabetic properties. Its primary active compounds include mogroside V, mogroside IV, mogrol, and vitamin C.
Mogrosides, especially mogroside V, act as potent agonists of the sweet taste receptor T1R2/T1R3, providing intense sweetness without caloric load. They also inhibit intestinal α-glucosidase and pancreatic α-amylase, reducing postprandial glucose spikes, and activate AMPK signaling to improve insulin sensitivity. Additionally, mogrosides scavenge reactive oxygen species and suppress NF-κB pathway activation, contributing to anti-inflammatory and antioxidant effects.
A Chinese gourd whose mogrosides are 150-300x sweeter than sugar with zero calories, used in TCM for coughs and longevity.
Monk fruit (Siraitia grosvenorii) is a Chinese gourd whose mogrosides, particularly mogroside V, provide a zero-calorie sweetness 150–300 times that of sucrose. Traditionally used in TCM for cough, sore throat, and as a longevity tonic, modern research indicates antioxidant, anti-inflammatory, and anti-diabetic properties. Its primary active compounds include mogroside V, mogroside IV, mogrol, and vitamin C.
Mogrosides, especially mogroside V, act as potent agonists of the sweet taste receptor T1R2/T1R3, providing intense sweetness without caloric load. They also inhibit intestinal α-glucosidase and pancreatic α-amylase, reducing postprandial glucose spikes, and activate AMPK signaling to improve insulin sensitivity. Additionally, mogrosides scavenge reactive oxygen species and suppress NF-κB pathway activation, contributing to anti-inflammatory and antioxidant effects.