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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Morus nigra (black mulberry) is a plant species known for its rich content of polyphenols and bioactive compounds, exhibiting wide-spectrum pharmacological effects including antioxidant, anti-inflammatory, and anticancer activities [PMID:30791521, PMID:39529942].
Contexte
Morus nigra L., commonly known as black mulberry, is a species of the Moraceae family native to Southwestern Asia [PMID:30791521]. It is utilized in the pharmaceutical, cosmetic, and food industries and is considered an unconventional food plant [PMID:39570176].
Usages traditionnels
It has been used as a traditional herbal medicine for both humans and animals [PMID:30791521]. In traditional Uygur medicine, the fruit is valued for its lipid-lowering and hepatoprotective effects [PMID:4049023도]. It is also traditionally used to address several diseases, specifically type II diabetes [PMID:31861822].
Composés actifs
The plant is rich in polyphenols, including flavonoids, anthocyanins (notably cyanidin-3-glucoside and cyanidin-3-rutinoside), and phenolic acids such as chlorogenic acid, cryptochlorogenic acid, and protocatechuic acid [PMID:39529942, PMID:37390741, PMID:35454757]. Other identified components include rutin, quercetin 3-O-glucoside, polysaccharides, and the alkaloid deoxynojirimycin (DNJ) [PMID:38169394, PMID:33450344, PMID:40807388].
Mécanisme d'action
Morus nigra exerts effects through antioxidant capacity and the inhibition of $\alpha$-glucosidase, $\alpha$-amylase, and lipase [PMID:30791521, PMID:37390741]. Specific mechanisms include the activation of the Nrf2 signaling pathway to reduce ROS and improve mitochondrial function [PMID:33450344], activation of the DAF-16 nuclear translocation in C. elegans [PMID:36076399], and attenuation of colitis via the TNF-$\alpha$/NF-$\kappa$B/ICAM-1 signaling pathway [PMID:40455241]. In hepatocellular carcinoma, natural lipid nanoparticles from the leaves trigger mitochondrial damage and oxidative stress via galactose receptor-mediated endocytosis [PMID:38169394].
Preuves cliniques
Preuve BMild-to-moderate Alzheimer's dementia
Daily administration of 20g of black mulberry concentrate for 12 weeks may slightly improve cognitive function, as evidenced by decreased ADAS-Cog scores [PMID:38052130].
Preuve DHepatocellular carcinoma
Natural exosome-like lipid nanoparticles (LNPs) from leaves suppressed viability, migration, and invasion of liver tumor cell lines in vitro [PMID:38169394].
Preuve DColitis
Polysaccharides from black mulberry alleviated symptoms, histological damage, and inflammation in mice by modulating gut microbiota [PMID:40455241].
Preuve DBenign Prostatic Hyperplasia (BPH)
Fruit hydroalcoholic extract significantly affected prostate weight and serum prostate-specific antigen levels in rats [PMID:31899187].
Sécurité et effets indésirables
Black mulberry fruit juice showed no genotoxicity in vitro and demonstrated protective activity against chromosomal aberrations induced by mitomycin C [PMID:31664310].
Synthèse des preuves
The evidence consists primarily of in vitro studies, animal models (mice, rats, C. elegans), and one small pilot feasibility study in humans. While preclinical data strongly suggest antioxidant and anti-inflammatory properties, clinical evidence for cognitive improvement is limited to a single pilot study.
Sources PubMed
1.PMID: 38169394 (2024) — Natural lipid nanoparticles extracted from Morus nigra L. leaves for targeted treatment of hepatocellular carcinoma via the oral route. · Journal of nanobiotechnology
2.PMID: 39529942 (2024) — Black Mulberry (Morus nigra L.): A Review of Attributes as an Anticancer Agent to Encourage Pharmaceutical Development. · Advances in pharmacological and pharmaceutical sciences
3.PMID: 30791521 (2019) — Pharmacological Properties of Morus nigra L. (Black Mulberry) as A Promising Nutraceutical Resource. · Nutrients
4.PMID: 39570176 (2024) — Prospection on the black mulberry (Morus nigra L.): A technological and scientific analysis. · Anais da Academia Brasileira de Ciencias
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Black mulberry (Morus nigra) fruit extract alleviated AD-Like symptoms induced by toxic Aβ protein in transgenic Caenorhabditis elegans via insulin DAF-16 signaling pathway.
· Food research international (Ottawa, Ont.)
6.PMID: 35454757 (2022) — Phytochemicals, Pharmacological Effects and Molecular Mechanisms of Mulberry. · Foods (Basel, Switzerland)
7.PMID: 38052130 (2024) — The effect of black mulberry (Morus nigra) consumption on cognition in patients with mild-to-moderate Alzheimer's dementia: A pilot feasibility study. · Geriatric nursing (New York, N.Y.)
8.PMID: 31664310 (2019) — Genotoxic and Genoprotective Potential of Black Mulberry (Morus nigra) Fruit. · Anais da Academia Brasileira de Ciencias
9.PMID: 31983015 (2020) — Inhibitory activity of black mulberry (Morus nigra) extract against testicular, liver and kidney toxicity induced by paracetamol in mice. · Molecular biology reports
10.PMID: 31899187 (2021) — Protective effect of black mulberry (Morus nigra L.) fruit hydroalcoholic extract against testosterone-induced benign prostatic hyperplasia in rats. · Revista internacional de andrologia
11.PMID: 33450344 (2021) — Black mulberry (Morus nigra L.) polysaccharide ameliorates palmitate-induced lipotoxicity in hepatocytes by activating Nrf2 signaling pathway. · International journal of biological macromolecules
12.PMID: 31555027 (2019) — Formulation of Antioxidant Gel from Black Mulberry Fruit Extract (Morus nigra L.). · Journal of pharmacy & bioallied sciences
13.PMID: 40807388 (2025) — Insights into the Activities and Usefulness of Deoxynojirimycin and Morus alba: A Comprehensive Review. · Molecules (Basel, Switzerland)
14.PMID: 35883830 (2022) — Diversity of Phytochemical and Antioxidant Characteristics of Black Mulberry (Morus nigra L.) Fruits from Turkey. · Antioxidants (Basel, Switzerland)
15.PMID: 35563975 (2022) — Evaluation of Different Black Mulberry Fruits (Morus nigra L.) Based on Phenolic Compounds and Antioxidant Activity. · Foods (Basel, Switzerland)
16.PMID: 33849010 (2021) — Protective Effects of Morus nigra and Its Phytochemicals against Hepatotoxicity: A Review of Preclinical Studies. · Pharmacology
17.PMID: 31861822 (2019) — Identification of Bioactive Phytochemicals in Mulberries. · Metabolites
18.PMID: 37390741 (2023) — Comprehensive structural analysis of polyphenols and their enzymatic inhibition activities and antioxidant capacity of black mulberry (Morus nigra L.). · Food chemistry
19.PMID: 37605394 (2024) — Herbal Technological Prospects of Morus nigra L.: A Systematic Patent Analysis Review. · Recent patents on biotechnology
20.PMID: 26510817 (2016) — Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of D-galactose-induced aging mice. · Pharmaceutical biology
21.PMID: 37569399 (2023) — Blackberries and Mulberries: Berries with Significant Health-Promoting Properties. · International journal of molecular sciences
22.PMID: 40490232 (2025) — Hepatoprotective activity of mulberry extract in NAFLD mice for regulating lipid metabolism and inflammation identified via AMPK/PPAR-γ/NF-κB axis. · Journal of ethnopharmacology
23.PMID: 40455241 (2025) — Polysaccharides from Black Mulberry Attenuate Colitis through Gut Microbiota Mediated TNF-α/pNF-κB/ICAM-1 Signaling Pathway. · Journal of agricultural and food chemistry
24.PMID: 38144770 (2023) — Effects of adding milk to fermented black mulberry (Morus nigra L.) juice on its antioxidant activity in C2C12 cells and changes in volatile flavor compounds during storage. · Food chemistry: X
25.PMID: 14692435 (2003) — Fig and mulberry cross-allergy. · Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
26.PMID: 33007366 (2020) — Dietary supplementation of black mulberry (Morus nigra) syrup improves the growth performance, innate immune response, antioxidant status, gene expression responses, and disease resistance of Nile tilapia (Oreochromis niloticus). · Fish & shellfish immunology
27.PMID: 30524657 (2018) — Anti-Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS-Induced Sepsis. · Oxidative medicine and cellular longevity