Poivre des montagnes (Tasmannia lanceolata): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Mountain Pepper work as an antimicrobial?

Mountain Pepper (Tasmannia lanceolata) exerts its antimicrobial effects primarily through polygodial, a sesquiterpene dialdehyde that disrupts bacterial and fungal cell membranes. This compound damages membrane integrity, leading to cell death in various pathogenic organisms. Laboratory studies demonstrate activity against both gram-positive and gram-negative bacteria, as well as certain fungi (Evidence Level C). Aboriginal Tasmanians traditionally used this plant for treating infections and wound care, applications now supported by in vitro research confirming these antimicrobial properties.

Can Mountain Pepper interact with any medications?

Currently, there are no well-documented drug interactions for Mountain Pepper in clinical literature (Evidence Level D). However, due to its potential gastrointestinal irritating effects, caution is advised when combining with medications that can damage the stomach lining, such as NSAIDs, aspirin, or corticosteroids. Those taking anticoagulant medications should also exercise caution, as limited safety data exists. Consult a healthcare provider before using therapeutic doses alongside any prescription medications.

What is the recommended dosage for Mountain Pepper?

The typical adult dosage for Mountain Pepper is small amounts as a culinary spice or 1-2 grams of standardized extract daily (Evidence Level C). Due to the potent polygodial content and potential for gastrointestinal irritation, higher doses are not recommended. Traditional Aboriginal use involved moderate quantities as both food flavoring and medicine. Individuals new to this herb should start with smaller amounts to assess tolerance before increasing intake.

Is Mountain Pepper safe during pregnancy and breastfeeding?

Mountain Pepper is considered unsafe during pregnancy and should be avoided (Evidence Level D). The active compound polygodial may stimulate uterine contractions and poses potential risks to fetal development. There is insufficient safety data regarding use during breastfeeding, so avoidance is recommended for nursing mothers. While trace amounts as a food spice may pose minimal risk, therapeutic doses should be strictly avoided. Pregnant or breastfeeding women should consult their healthcare provider before use.

What are the side effects of Mountain Pepper?

Mountain Pepper may cause gastrointestinal irritation, particularly when consumed in large amounts or concentrated extracts (Evidence Level C). Reported side effects include stomach discomfort, nausea, and burning sensations in the digestive tract. Individuals with gastric ulcers, acid reflux, or inflammatory bowel conditions should avoid therapeutic doses, as the irritating compounds may exacerbate these conditions. Discontinue use if digestive symptoms develop and seek medical advice if symptoms persist or worsen.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Tasmannia lanceolata, also known as Tasmanian mountain pepper, is an Australian native shrub containing bioactive drimane sesquiterpenoids and polyphenols [PMID:31851503, PMID:36829816].

Contexte

Tasmannia lanceolata is a fleshy-fruited, bird-dispersed shrub widespread in the mountains of southeastern Australia and Tasmania [PMID:20609080]. It belongs to the Winteraceae family [PMID:33537417, PMID:21653389].

Composés actifs

The plant contains drimane sesquiterpenoids, most notably polygodial, as well as 1β-acetoxy-9-deoxyisomuzigadial and 3β-acetoxydrimenin [PMID:31851503, PMID:28657737]. It also contains polyphenols, including phenolic acids, flavonols, and anthocyanins (specifically in the berries) [PMID:39406142, PMID:36829816].

Mécanisme d'action

Polygodial and related drimane sesquiterpenes activate the Transient Receptor Potential Channel A1 (TRPA1), inducing calcium influx into trigeminal neurons [PMID:28657737]. In cancer cell lines, polygodial activates apoptotic signaling by inducing oxidative stress [PMID:36358679].

Preuves cliniques

Preuve BStretch marks

Topical application of Tasmannia lanceolata leaf extract (TLE) for 8 weeks alleviated the appearance of stabilized stretch marks in women [PMID:33048421]

Preuve DCastration-resistant prostate cancer (CRPC)

Polygodial inhibited cell viability, colony formation, and migration of taxane-resistant CRPC cell lines and induced G0 phase cell cycle arrest in vitro [PMID:36358679]

Preuve DVarious cancer cell lines

Polyphenolic-rich extracts reduced the proliferation of colon (HT-29), stomach (AGS), bladder (BL13), and liver (HepG2) cancer cells in vitro [PMID:23017386]

Sécurité et effets indésirables

In zebrafish embryo toxicology screening, the extract was characterized for safety and antioxidant potential [PMID:35883771]. Polygodial was reported to be non-toxic to primary human hepatocytes and 3T3-cells [PMID:36358679].

Synthèse des preuves

Evidence is primarily preclinical (in vitro and animal models) focusing on phytochemical properties and antimicrobial/anticancer activity, with one small randomized controlled trial (n=29) supporting topical use for stretch marks.

Sources PubMed

1.PMID: 31851503 (2020) — Distinct Drimane Chemotypes in Tasmanian Mountain Pepper (Tasmannia lanceolata): Differences in the Profiles of Pungent Leaf Phytochemicals Associated with Altitudinal Cline. · Journal of agricultural and food chemistry
2.PMID: 28657737 (2017) — Structure-Pungency Relationships and TRP Channel Activation of Drimane Sesquiterpenes in Tasmanian Pepper (Tasmannia lanceolata). · Journal of agricultural and food chemistry
3.PMID: 33048421 (2021) — Tasmannia lanceolata leaf extract alleviates stretch mark appearance in a randomized, placebo-controlled clinical trial in women and stimulates extracellular matrix synthesis in ex vivo human skin explants. · Journal of cosmetic dermatology
4.PMID: 39406142 (2025) — Effects of polyphenols from Tasmannia lanceolata on structural, emulsifying, and antioxidant properties of pea protein. · Food chemistry
5.PMID: 36076815

Poivre des montagnes

Sources et citations

Calculer une dose sûre de Poivre des montagnes

Corchorus Olitorius

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Questions fréquentes

Résumé

Contexte

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Poivre des montagnes

Sources et citations

Calculer une dose sûre de Poivre des montagnes

Plantes associées

Corchorus Olitorius

Salvia nemorosa

Origanum Minutiflorum

Questions fréquentes

Résumé

Contexte

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales