Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 17 articles PubMed · modèle : gemma4:31b
Résumé
Nigella arvensis is a medicinal herb used traditionally as a galactogogue and anti-inflammatory remedy [PMID:30000936, PMID:28553226].
Contexte
Nigella arvensis is a species of the genus Nigella (Family Ranunculaceae) found in regions including the Aegean archipelago, Greece, and Turkey [PMID:37598984, PMID:19459745].
Usages traditionnels
It has been used orally as a galactogogue in India, Türkiye, and the Middle East [PMID:30000936], and is widely used as an anti-inflammatory remedy in the traditional medicine of Northern Africa [PMID:28553226]. In Turkey, it is also used for aphrodisiac effects [PMID:26281312].
Composés actifs
The seeds contain proteins (albumin, globulin, glutein-1, glutein-2, and prolamin) [PMID:28407892], amino acids including L-aspartic acid, L-leucine, L-valine, and L-tyrosine [PMID:39916614], and phytosterols such as β-sitosterol, stigmasterol, and campesterol [PMID:28553226]. Other identified constituents include glaucine, quercetin, kaempferol [PMID:32613127], flavonoids, and phenolic compounds [PMID:28541741].
Mécanisme d'action
β-sitosterol from N. arvensis seed extracts inhibits the expression of the pro-inflammatory neutrophil chemokine Interleukin (IL)-8 in bronchial epithelial cells exposed to Pseudomonas aeruginosa [PMID:28553226]. Seed extracts also stimulate Na+ transport in renal epithelia, an effect caused by adenosine [PMID:12409499].
Preuves cliniques
Preuve DLactation (Galactogogue)
No scientifically valid clinical trials support this use in humans; one study showed a slight increase in serum prolactin compared to placebo, but no evidence of growth promotion in infants [PMID:30000936].
Preuve DBacterial/Yeast Infections
Chloroform extracts of N. arvensis demonstrated potent antimicrobial activity against Gram-positive bacteria and yeast strains in vitro [PMID:19459745].
Sécurité et effets indésirables
Limited information indicates the herb is generally well tolerated, though black seed oil can cause allergic contact dermatitis [PMID:30000936]. In vitro testing of extracts (water, methanol, and chloroform) was conducted for cyto- and genotoxic potentials in rat kidney cells and Salmonella typhimurium [PMID:26281312].
Grossesse et allaitement
Used traditionally as a galactogogue [PMID:30000936]. However, no data exist on the excretion of components into breastmilk or the safety and efficacy of the herb in infants [PMID:30000936].
Synthèse des preuves
The available evidence is primarily based on in vitro studies, phytochemical analyses, and traditional use reports; there is a lack of scientifically valid human clinical trials.
Sources PubMed
- 1.PMID: 30000936 (2006) — Biological Potentials and Phytochemical Constituents of Raw and Roasted Nigella arvensis and Nigella sativa. · Molecules (Basel, Switzerland)
- 2.PMID: 28407892 (2017) — Molecular characterization and bio-functional property determination using SDS-PAGE and RP-HPLC of protein fractions from two Nigella species. · Food chemistry
- 3.PMID: 34715233 (2022) — Uptake, translocation, phytotoxicity, and hormetic effects of titanium dioxide nanoparticles (TiO2NPs) in Nigella arvensis L. · The Science of the total environment
- 4.PMID: 37598984 (2023) — Phylogenomic and population genomic analyses reveal the spatial-temporal dynamics of diversification of the Nigella arvensis complex (Ranunculaceae) in the Aegean archipelago. · Molecular phylogenetics and evolution
- 5.PMID: 39916614 (2025) — Comparative Chromatographic Analysis of Amino Acids in the Seeds of Three Nigella L. Representatives.