Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
PubMed · Phytophthora morindae, a new species causing black flag disease on noni (Morinda citrifolia L) in Hawaii. (2010)
PubMed · Antihypertensive Plants Used by the Anak Dalam Tribe in Jambi, Indonesia: Ethnobotanical Insights and Pharmacological Potential as Alternatives to Conventional Medicine. (2026)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Dernière mise à jour : April 2026
Calculer une dose sûre de Noni Tahitien
Calculateur gratuit de posologie — doses adultes et enfants selon le poids.
Noni contains several bioactive compounds that may contribute to its effects. Scopoletin has demonstrated anti-inflammatory properties in laboratory studies, while damnacanthal and morindone have shown potential anticancer activity in cell-based research. Proxeronine is theorized to support cellular function through xeronine production, though this mechanism remains unproven in humans. The fruit also provides antioxidants that may help reduce oxidative stress. Evidence for these mechanisms is preliminary (Level C), and more rigorous human clinical trials are needed to confirm these theoretical actions.
Does Noni interact with any medications?
Yes, Noni has several important drug interactions. Due to its high potassium content, Noni juice can interact with potassium-sparing diuretics, ACE inhibitors, and angiotensin receptor blockers, potentially causing dangerous hyperkalemia. Noni may enhance the effects of blood pressure medications, leading to hypotension. Rare cases of hepatotoxicity have been reported, so caution is warranted with other liver-metabolized drugs. Patients on anticoagulants should also use Noni with caution. Always consult a healthcare provider before combining Noni with prescription medications.
What is the recommended daily dosage for Noni juice?
For adults, the typical recommended dosage is 30-60ml of pure Noni juice daily, taken in one or two divided doses. For concentrated extract forms, 500mg daily is commonly used. Start with a lower dose to assess tolerance, as the strong taste may cause nausea in some individuals. Standardized products from reputable manufacturers are preferred for consistent dosing. There is insufficient clinical evidence to establish optimal dosing for specific health conditions. Always follow product label instructions and consult a healthcare provider for personalized guidance.
Is Noni safe to take during pregnancy?
No, Noni is considered unsafe during pregnancy. The fruit contains anthraquinone compounds that may stimulate uterine contractions, potentially causing miscarriage or premature labor. Additionally, the high potassium content poses risks for pregnant women with kidney concerns. There is insufficient safety data for breastfeeding women, so avoidance is recommended during lactation as well. Women who are pregnant, planning pregnancy, or breastfeeding should avoid all Noni products. Consult a qualified healthcare provider for safe alternatives during this time.
What are the side effects of taking Noni?
Common side effects include nausea and digestive discomfort, primarily due to Noni's strong, unpleasant taste. More serious concerns include hyperkalemia (elevated blood potassium), particularly in individuals with kidney disease or those on potassium-restricted diets. Rare cases of hepatotoxicity have been reported, making Noni unsuitable for people with liver disease. Those with kidney disease should avoid Noni entirely. Discontinue use immediately if you experience jaundice, dark urine, persistent fatigue, or unusual bleeding, and seek medical attention promptly.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Morinda citrifolia (Noni) is a plant of the Rubiaceae family used in traditional Polynesian medicine for over 2,000 years [PMID:11795436, PMID:26404212]. It is marketed globally as a dietary supplement, particularly in the form of fruit juice, for various health complaints [PMID:31840355, PMID:24083691].
Contexte
Noni Tahitian (Morinda citrifolia) is a perennial herb native to Southeast Asia and is also known as Indian mulberry, great morinda, or cheese fruit [PMID:31840355, PMID:33734250]. Tahitian noni juice was approved as a novel food by the European Commission in 2003 [PMID:26404212].
Usages traditionnels
Polynesians have used Noni for over 2,000 years to treat various ailments [PMID:11795436, PMID:26404212], including the combatting of fatigue [PMID:17604369] and the treatment of gout [PMID:19434757].
Composés actifs
Reported phytochemicals include iridoids, flavonoids, flavonoid glycosides, anthraquinones, coumarins, lignanas, noniosides, phenolics, triterpenoids, sugar derivatives, and neolignans [PMID:31840355, PMID:38358681].
Mécanisme d'action
Noni may modulate the immune system by activating cannabinoid 2 (CB2) receptors and inhibiting cannabinoid 1 (CB1) receptors, while suppressing IL-4 and increasing IFN-gamma production [PMID:18063495]. In vitro studies indicate it inhibits xanthine oxidase (XO) in a concentration-dependent manner [PMID:19434757].
Preuves cliniques
Preuve BCancer Chemoprevention
Drinking 1 to 4 oz of Tahitian Noni Juice (TNJ) for one month significantly reduced aromatic DNA adducts in peripheral blood lymphocytes of current smokers [PMID:19838937].
Preuve BGeneral Safety
A double-blind study of 96 healthy volunteers consuming up to 750 mL of TNJ daily for 28 days showed no clinically significant adverse effects and a trend toward fewer total adverse events compared to placebo [PMID:20443518].
Preuve BHepatotoxicity
A human clinical safety study and animal toxicity tests revealed no evidence of adverse liver effects at doses higher than those reported in isolated case studies [PMID:16773722].
Preuve DBreast Cancer (Animal Model)
TNJ resulted in significant reductions in tumor weight and volume and longer tumor doubling times in mice with HER2/neu breast cancer [PMID:22619689].
Preuve DAnti-diabetic (Animal Model)
Fermented noni fruit juice demonstrated anti-diabetic effects in animal models [PMID:26404212].
Sécurité et effets indésirables
Noni juice is generally considered safe based on toxicological assessments [PMID:24083691] and has been approved as a safe food within the European Union [PMID:16773722]. While three cases of acute hepatitis were published in Austria, subsequent clinical safety studies found no evidence of liver toxicity [PMID:16773722].
Grossesse et allaitement
In Wistar rats, exposure to noni aqueous extract or Tahitian Noni juice during pregnancy induced delayed ossification in fetuses [PMID:20038450].
Synthèse des preuves
Evidence is primarily based on in vitro studies, animal models, and limited clinical safety trials. While some human data exists regarding DNA adduct reduction and general safety, clinical data for treating specific diseases are essentially lacking [PMID:24083691].
Sources PubMed
1.PMID: 31840355 (2020) — Indian Morinda species: A review. · Phytotherapy research : PTR
2.PMID: 26404212 (2015) — Anti-Diabetic Potential of Noni: The Yin and the Yang. · Molecules (Basel, Switzerland)
3.PMID: 11795436 (2001) — Cancer preventive effect of Morinda citrifolia (Noni). · Annals of the New York Academy of Sciences
4.PMID: 24083691 (2013) — Do the health claims made for Morinda citrifolia (Noni) harmonize with current scientific knowledge and evaluation of its biological effects. · Asian Pacific journal of cancer prevention : APJCP
5.PMID: 16773722 (2006) — Noni juice is not hepatotoxic. · World journal of gastroenterology
6.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
PMID: 38358681 (2024) — Anticancer and chemopreventive potential of Morinda citrifolia L. bioactive compounds: A comprehensive update. · Phytotherapy research : PTR
7.PMID: 23082808 (2012) — Antipsychotic-like activity of noni (Morinda citrifolia Linn.) in mice. · BMC complementary and alternative medicine
8.PMID: 19434757 (2009) — Xanthine oxidase inhibiting effects of noni (Morinda citrifolia) fruit juice. · Phytotherapy research : PTR
9.PMID: 17604369 (2007) — Evaluation of the ergogenic potential of noni juice. · Phytotherapy research : PTR
10.PMID: 19838937 (2009) — Morinda citrifolia (noni) reduces cancer risk in current smokers by decreasing aromatic DNA adducts. · Nutrition and cancer
11.PMID: 22619689 (2012) — Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c-erbB2 Transgene. · Evidence-based complementary and alternative medicine : eCAM
12.PMID: 20443518 (2009) — A double-blind clinical safety study of noni fruit juice. · Pacific health dialog
13.PMID: 18063495 (2008) — The effects of Morinda citrifolia L. (noni) on the immune system: its molecular mechanisms of action. · Journal of ethnopharmacology
14.PMID: 20038450 (2010) — Delayed ossification in Wistar rats induced by Morinda citrifolia L. exposure during pregnancy. · Journal of ethnopharmacology
15.PMID: 33734250 (2021) — Immunomodulatory effect of Noni fruit and its isolates: insights into cell-mediated immune response and inhibition of LPS-induced THP-1 macrophage inflammation. · Food & function