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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 27 articles PubMed · modèle : gemma4:31b
Résumé
Euphorbia thymifolia is a tropical herb used in traditional medicine for various ailments, showing antioxidant, anti-inflammatory, and antiviral activities in experimental models [PMID:12432232, 27618898, 24501446].
Contexte
Euphorbia thymifolia L. (Euphorbiaceae), also known as laghududhika or choti-dudhi, is a small, branched, hispidly pubescent, prostate annual herb [PMID:24501446].
Usages traditionnels
In Ayurveda and folk medicine, it is used to treat bronchial asthma, cough, diarrhea, bleeding piles [PMID:30671367], worm infections, and as a stimulant or astringent [PMID:24501446]. It is used in India and Indonesia as a galactogue to improve the quality of colostrum [PMID:30000943], and in Bangladesh for the treatment of diabetes and pain [PMID:22313890]. It is also used in traditional Chinese medicine for rheumatoid arthritis [PMID:38643905].
Composés actifs
Identified compounds include jatrophane-type diterpenoids (euphothymifols A and B, euphthymifolols A-E, euphthymifolone A, euphoscopin F, L, and E) [PMID:40608911, 40085800, 41507717], abietane-type diterpenoids [PMID:41507717], alkaloids (aurantiamide, anabellamide) [PMID:33350239, 41507717], isocoumarins, thymol derivatives, ellagic acids [PMID:33350239], cinnamic acid derivatives (thymofolinoates A and B) [PMID:23157007], and the pseudoguaianolide 6-O-angeloylplenolin [PMID:38643905].
Mécanisme d'action
The herb may suppress inflammatory responses via upregulation of Phase II enzymes and modulation of NF-κB and JNK activation in microglia [PMID:27618898]. 6-O-angeloylplenolin inhibits osteoclastogenesis by suppressing c-Src/NF-κB/NFATc1 pathways [PMID:38643905]. It may also modulate the Keap1-Nrf2 pathway to exert antioxidant effects [PMID:41511542].
Preuves cliniques
Preuve DHepatotoxicity
Ethanolic extracts exhibited potential in vitro antioxidant activity and protective effects against carbon tetrachloride-induced hepatotoxicity in Wistar rats [PMID:36268597]
Preuve DAsthma/Anaphylaxis
Methanol and aqueous extracts showed antiasthmatic and antianaphylactic activity in experimental animals [PMID:30671367]; water-soluble fractions may cause relaxation of smooth muscles to relieve bronchial spasms [PMID:22557397]
Preuve DHerpes Simplex Virus-2 (HSV-2)
Ethyl acetate extract and 3-O-galloyl-4,6-(S)-HHDP-D-glucose inhibit HSV-2 multiplication by reducing virus infectivity in vitro [PMID:15854140, 12432232]
Preuve DDiabetes
Methanolic extract showed antihyperglycemic activity in glucose-loaded mice [PMID:22313890]
Preuve DRheumatoid Arthritis
6-O-angeloylplenolin attenuated bone erosion and severity of arthritis in collagen-induced arthritis mouse models [PMID:38643905]
Sécurité et effets indésirables
No specific adverse effects are detailed in the provided abstracts, though a review mentions that compiled data reflects the safety of the plant [PMID:24501446].
Grossesse et allaitement
Used traditionally as a galactogue in India and Indonesia, but no scientifically valid clinical trials support this use, and no data exist on the excretion of its components into breastmilk [PMID:30000943].
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (Level D), with no human clinical trials provided in the abstracts.
Sources PubMed
1.PMID: 30000943 (2006) — Sesquiterpenes and diterpenes from Euphorbia thymifolia. · Fitoterapia
2.PMID: 36268597 (2022) — Protective effect of Euphorbia thymifolia and Euphorbia hirta against carbon tetrachloride-induced hepatotoxicity in Wistar rats. · Drug development and industrial pharmacy
3.PMID: 30671367 (2019) — Anti-anaphylactic and antiasthmatic activity of Euphorbia thymifolia L. on experimental animals. · Journal of traditional and complementary medicine
4.PMID: 24501446 (2013) — A review on phyto-pharmacological potentials of Euphorbia thymifolia L. · Ancient science of life
5.PMID: 33350239 (2020) — [Study on chemical constituents from Euphorbia thymifolia].
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
· Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
6.PMID: 40574789 (2024) — Molecular docking and dynamics studies to identify novel active compounds targeting potential breast cancer receptor proteins from an indigenous herb Euphorbia thymifolia Linn. · F1000Research
7.PMID: 27588252 (2016) — An in silico study on antidiabetic activity of bioactive compounds in Euphorbia thymifolia Linn. · SpringerPlus
8.PMID: 40608911 (2025) — Euphothymifols a and B, novel bioactive bicyclic jatrophane-type diterpenoids from euphorbia thymifolia L. · Natural product research
9.PMID: 12432232 (2002) — Antioxidant and antiviral activities of Euphorbia thymifolia L. · Journal of biomedical science
10.PMID: 36849684 (2023) — Effective removal of Ni(II) ions from its aqueous solution by utilizing Euphorbia thymifolia as an adsorbent. · Environmental science and pollution research international
11.PMID: 40085800 (2026) — Euphthymifolols A-E, anti-inflammatory jatrophane-type macrocyclic diterpenoids from Euphorbia thymifolia L. · Natural product research
12.PMID: 15854140 (2005) — Euphorbia thymifolia suppresses herpes simplex virus-2 infection by directly inactivating virus infectivity. · Clinical and experimental pharmacology & physiology
13.PMID: 41511542 (2026) — GC-MS phytochemical screening, molecular docking, MD simulation, and in vitro antioxidant assay of Euphorbia thymifolia L. extract. · Naunyn-Schmiedeberg's archives of pharmacology
14.PMID: 27618898 (2016) — Cleome rutidosperma and Euphorbia thymifolia Suppress Inflammatory Response via Upregulation of Phase II Enzymes and Modulation of NF-κB and JNK Activation in LPS-Stimulated BV2 Microglia. · International journal of molecular sciences
15.PMID: 41507717 (2025) — [A new jatrophane diterpenoid with anti-inflammatory activity from Euphorbia thymifolia]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
16.PMID: 26890384 (2016) — Green synthesis of Pd nanoparticles mediated by Euphorbia thymifolia L. leaf extract: Catalytic activity for cyanation of aryl iodides under ligand-free conditions. · Journal of colloid and interface science
17.PMID: 3169896 (1988) — Antibacterial activity of Euphorbia thymifolia Linn. · The Indian journal of medical research
18.PMID: 38643905 (2024) — 6-O-angeloylplenolin inhibits osteoclastogenesis in vitro via suppressing c-Src/NF-κB/NFATc1 pathways and ameliorates bone resorption in collagen-induced arthritis mouse model. · Biochemical pharmacology
19.PMID: 22313890 (2012) — Antihyperglycemic and antinociceptive activities of methanolic extract of Euphorbia thymifolia L. whole plants. · Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
20.PMID: 29065826 (2017) — Green Synthesis of Palladium/Titanium Dioxide Nanoparticles and their Application for the Reduction of Methyl Orange, Congo Red and Rhodamine B in Aqueous Medium. · Combinatorial chemistry & high throughput screening
21.PMID: 18176816 (2008) — Isolation and identification of mosquito larvicidal compound from Abutilon indicum (Linn.) Sweet. · Parasitology research
22.PMID: 23157007 (2012) — Thymofolinoates A and B, new cinnamic acid derivatives from Euphorbia thymifolia. · Natural product communications
23.PMID: 22557397 (1984) — Experimental evaluation of dugdhika (euphorbia prostrata w. Ait) for the treatment of 'tamaka svasa' (bronchial asthma). · Ancient science of life
24.PMID: 27657818 (2016) — Toxicity and physiological effect of quercetin on generalist herbivore, Spodoptera litura Fab. and a non-target earthworm Eisenia fetida Savigny. · Chemosphere
25.PMID: 24432368 (2013) — Plants used for treatment of dysentery and diarrhoea by the Bhoxa community of district Dehradun, Uttarakhand, India. · Journal of ethnopharmacology
26.PMID: 21952437 (2011) — Antidiabetic and antioxidant potentials of Euphorbia hirta leaves extract studied in streptozotocin-induced experimental diabetes in rats. · General physiology and biophysics