Loading...
Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Loading...
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Phellodendron amurense
Bitter TCM bark used to clear heat and dampness, particularly for urinary tract infections, inflammation, and skin conditions.
Phellodendron amurense is a traditional Chinese medicinal bark used to clear heat and dampness, particularly for urinary tract infections, inflammation, and skin conditions. Its primary active compounds include berberine, phellodendrine, obacunone, and palmatine, which contribute to its antimicrobial, anti-inflammatory, and hypoglycemic effects. Evidence level C indicates limited or preliminary clinical data supporting these uses.
Berberine, the major alkaloid, activates AMP-activated protein kinase (AMPK) and inhibits nuclear factor-κB (NF-κB), leading to reduced inflammation and improved insulin sensitivity. It also disrupts bacterial cell membranes and inhibits bacterial enzymes such as DNA gyrase. Phellodendrine and obacunone modulate mitogen-activated protein kinase (MAPK) and nuclear factor erythroid 2-related factor 2 (Nrf2) pathways, contributing to antioxidant and anti-inflammatory effects. Additionally, berberine inhibits CYP2D6 and CYP3A4, potentially affecting drug metabolism.
Bitter TCM bark used to clear heat and dampness, particularly for urinary tract infections, inflammation, and skin conditions.
Phellodendron amurense is a traditional Chinese medicinal bark used to clear heat and dampness, particularly for urinary tract infections, inflammation, and skin conditions. Its primary active compounds include berberine, phellodendrine, obacunone, and palmatine, which contribute to its antimicrobial, anti-inflammatory, and hypoglycemic effects. Evidence level C indicates limited or preliminary clinical data supporting these uses.
Berberine, the major alkaloid, activates AMP-activated protein kinase (AMPK) and inhibits nuclear factor-κB (NF-κB), leading to reduced inflammation and improved insulin sensitivity. It also disrupts bacterial cell membranes and inhibits bacterial enzymes such as DNA gyrase. Phellodendrine and obacunone modulate mitogen-activated protein kinase (MAPK) and nuclear factor erythroid 2-related factor 2 (Nrf2) pathways, contributing to antioxidant and anti-inflammatory effects. Additionally, berberine inhibits CYP2D6 and CYP3A4, potentially affecting drug metabolism.