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Phyllanthus maderaspatensis
Indian Phyllanthus species used in Ayurveda and Siddha medicine for liver, skin, and urinary conditions.
Phyllanthus maderaspatensis is an Indian herb used in Ayurveda and Siddha medicine primarily for hepatoprotective, antioxidant, and antimicrobial purposes. Its key bioactive compounds include phyllanthin, geraniin, ellagic acid, and quercetin, which contribute to its therapeutic effects on liver, skin, and urinary conditions.
The hepatoprotective effects are mediated through inhibition of cytochrome P450 enzymes (e.g., CYP2E1) and upregulation of antioxidant enzymes such as superoxide dismutase and catalase, reducing oxidative stress. Phyllanthin and geraniin modulate NF-κB and Nrf2 pathways, decreasing pro-inflammatory cytokines and enhancing phase II detoxification. Antimicrobial activity involves disruption of bacterial cell membranes and inhibition of efflux pumps, while quercetin and ellagic acid provide additional antioxidant and anti-inflammatory actions via scavenging free radicals and inhibiting lipoxygenase.
Indian Phyllanthus species used in Ayurveda and Siddha medicine for liver, skin, and urinary conditions.
Phyllanthus maderaspatensis is an Indian herb used in Ayurveda and Siddha medicine primarily for hepatoprotective, antioxidant, and antimicrobial purposes. Its key bioactive compounds include phyllanthin, geraniin, ellagic acid, and quercetin, which contribute to its therapeutic effects on liver, skin, and urinary conditions.
The hepatoprotective effects are mediated through inhibition of cytochrome P450 enzymes (e.g., CYP2E1) and upregulation of antioxidant enzymes such as superoxide dismutase and catalase, reducing oxidative stress. Phyllanthin and geraniin modulate NF-κB and Nrf2 pathways, decreasing pro-inflammatory cytokines and enhancing phase II detoxification. Antimicrobial activity involves disruption of bacterial cell membranes and inhibition of efflux pumps, while quercetin and ellagic acid provide additional antioxidant and anti-inflammatory actions via scavenging free radicals and inhibiting lipoxygenase.