Phyllanthus maderaspatensis (Phyllanthus maderaspatensis): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Phyllanthus maderaspatensis protect the liver?

Phyllanthus maderaspatensis exerts hepatoprotective effects primarily through its antioxidant compounds, including phyllanthin, geraniin, ellagic acid, and quercetin. These bioactive constituents help neutralize free radicals and reduce oxidative stress in liver cells. The herb may also modulate inflammatory pathways and support liver enzyme regulation. Evidence level C studies suggest protective effects against liver damage, though more clinical research is needed to fully understand the mechanism.

Does Phyllanthus maderaspatensis interact with any medications?

There is limited research on specific drug interactions for Phyllanthus maderaspatensis. Due to its effects on liver enzymes and hepatoprotective properties, it may theoretically interact with medications metabolized by the liver. Patients taking prescription medications, particularly those for liver conditions or blood sugar management, should consult a healthcare provider before use. No significant clinical drug interactions have been documented in available literature.

What is the recommended dosage of Phyllanthus maderaspatensis?

The traditional adult dosage for Phyllanthus maderaspatensis is 5-10 grams of dried herb prepared as a decoction daily. This preparation involves boiling the herb in water and straining before consumption. Dosage may vary based on the specific condition being addressed and individual factors. It is advisable to follow guidance from a qualified Ayurvedic or Siddha practitioner for personalized dosing recommendations.

Is Phyllanthus maderaspatensis safe during pregnancy?

Phyllanthus maderaspatensis is considered unsafe during pregnancy and is contraindicated for pregnant women. Traditional Ayurvedic and Siddha texts advise against its use in pregnancy, though specific mechanisms for this contraindication are not well documented in modern research. Women who are pregnant, planning to become pregnant, or breastfeeding should avoid this herb and consult a qualified healthcare provider for appropriate alternatives.

What are the traditional uses of Phyllanthus maderaspatensis in Ayurveda?

Phyllanthus maderaspatensis has been used traditionally in Ayurvedic and Siddha medicine for liver conditions, skin disorders, and urinary complaints. In Siddha medicine specifically, it is valued for its hepatoprotective properties. The herb is also employed for its antioxidant effects. Evidence level C supports these traditional applications, though more rigorous clinical studies are needed to validate efficacy for these conditions.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 16 articles PubMed · modèle : gemma4:31b

Résumé

Phyllanthus maderaspatensis is a medicinal herb used in traditional Indian medicine, primarily recognized for its hepatoprotective properties [PMID:16236476, PMID:25829765].

Contexte

Phyllanthus maderaspatensis (Euphorbiaceae) is a traditional medicinal herbaceous plant found in India [PMID:16236476, PMID:41653262]. It is often sold under the trade name 'Bhuiamlki' and is phylogenetically sister to all other species of Phyllanthus [PMID:16236476, PMID:21646224].

Usages traditionnels

In Indian indigenous systems of medicine, it is used as a remedy for jaundice and hepatitis, and is considered bitter, astringent, stomachic, diuretic, febrifuge, deobstruant, and antiseptic [PMID:16236476, PMID:25829765].

Composés actifs

The plant contains polyphenols including kaempferol, rutin, ellagic acid, quercetin, catechin, and gallic acid [PMID:35280567, PMID:25829765]. Other identified constituents include flavonoids, tannins, saponins, alkaloids, phenolic compounds, and phytosterols [PMID:40794262, PMID:29956900].

Mécanisme d'action

The herb exhibits antioxidant activity through hydroxyl radical scavenging and inhibition of lipid peroxidation [PMID:15099850]. It increases hepatic glutathione levels and prevents the elevation of serum enzymes such as AST, ALT, and LDH [PMID:17210231].

Preuves cliniques

Preuve DHepatotoxicity (CCl4, thioacetamide, acetaminophen, and galactosamine induced)

Extracts (hexane, alcoholic, hydroalcoholic, and aqueous) showed significant hepatoprotection, reducing histological damage and serum enzyme elevation in rat models [PMID:17210231, PMID:15099850, PMID:25829765].

Preuve DAdriamycin-induced toxicity and oxidative stress

Ethanol extract (400-600 mg/kg) provided dose-dependent protection against toxicity and oxidative stress in mice [PMID:18404314].

Preuve DInflammation and Pain

Chloroform extract (400 mg/kg) showed significant antinociceptive and anti-inflammatory effects in carrageenan-induced hind paw oedema in rats [PMID:29956900].

Preuve DHepatitis B Virus (DHBV in ducks)

Studies on ducklings showed no definite antiviral property in carrier ducks [PMID:8106861], though other studies evaluated it for postexposure prophylaxis [PMID:8515247].

Preuve Dt-BH-induced cytotoxicity (HepG2 cells)

The extract exhibited significant hepatoprotective activity by increasing cell viability [PMID:21969794].

Synthèse des preuves

The evidence is based entirely on in vitro studies and animal models (rats, mice, ducks), indicating strong hepatoprotective and antioxidant potential, but there are no human clinical trials provided.

Sources PubMed

1.PMID: 8515247 (1993) — Evaluation of Phyllanthus amarus and Phyllanthus maderaspatensis as agents for postexposure prophylaxis in neonatal duck hepatitis B virus infection. · Journal of medical virology
2.PMID: 16236476 (2006) — Comparative pharmacognostic studies of three Phyllanthus species. · Journal of ethnopharmacology
3.PMID: 35280567 (2022) — Densitometric Quantification and Optimization of Polyphenols in Phyllanthus maderaspatensis by HPTLC. · Saudi journal of biological sciences
4.PMID: 25829765 (2015) — Comparative evaluation of standardized alcoholic, hydroalcoholic, and aqueous extracts of Phyllanthus maderaspatensis Linn. against galactosamine-induced hepatopathy in albino rats. · Pharmacognosy magazine
5.PMID: 17210231 (2007) — Hepatoprotection of Phyllanthus maderaspatensis against experimentally induced liver injury in rats.

Phyllanthus maderaspatensis

Sources et citations

Calculer une dose sûre de Phyllanthus maderaspatensis

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Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Phyllanthus maderaspatensis

Sources et citations

Calculer une dose sûre de Phyllanthus maderaspatensis

Plantes associées

Carya illinoinensis

Pterocarpus santalinus

Paulownia tomentosa

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales