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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Potentilla anserina (silverweed cinquefoil) is a perennial herb used in traditional Chinese and Tibetan medicine as both a food and a medicinal resource [PMID:38909825, PMID:36717756]. It is recognized for its anti-inflammatory, hepatoprotective, and antioxidant properties [PMID:34288682, PMID:40636944].
Contexte
Potentilla anserina L. (Rosaceae), also known as silverweed cinquefoil or ginseng fruit, is a plant widely distributed in the Qinghai-Tibetan Plateau and western areas of China [PMID:38855725, PMID:34288682, PMID:37528998]. It is characterized as a clonal polyploid herb [PMID:39716778].
Usages traditionnels
Traditionally used in Chinese and Tibetan medicine to invigorate the spleen and stomach, quench thirst, tonify blood, astringe to stop bleeding, relieve diarrhea, and treat spleen deficiency [PMID:38909825, PMID:37528998]. It has also been used in folk medicine as an antitussive and expectorant [PMID:26695537].
Composés actifs
Active constituents include polysaccharides [PMID:39922353], flavonoids such as (+)-catechin, (+)-gallocatechin, and various quercetin and kaempferol glycosides [PMID:17238103], phenols [PMID:36717756], and pentacyclic triterpenoid saponins (e.g., poterinasides A-J and potentillanosides A-F) [PMID:34288682, PMID:24697904].
Mécanisme d'action
Polysaccharides (PAP) reduce inflammatory levels and M1 macrophage immune responses in acute lung injury [PMID:39922353] and inhibit pro-inflammatory cytokines (IL-1β, IL-6, TNF-α, VEGF, NF-κB, and HIF-1α) in hypobaric hypoxia models [PMID:34243609, PMID:32298011]. Flavonoids (PAF) modulate oxidative stress via the kelch-like ECH-associated protein pathway, reduce inflammatory cytokines, and restore intestinal microbiota balance [PMID:40636944]. Phenols improve insulin-stimulated glucose uptake by promoting Akt phosphorylation and suppress adipokine expression to decrease lipid droplet accumulation [PMID:36717756].
A combination extract containing silverweed (Gastritol Liquid) led to relevant improvements in vomiting (-66.7%) and retching (-52.2%) in patients with and without diabetes [PMID:26522087]
Preuve DAcute Lung Injury (ALI)
Polysaccharides (PAP) effectively reduced inflammatory levels and intestinal mucosal barrier impairment in LPS-induced mouse models [PMID:39922353]
Preuve DUlcerative Colitis (UC)
Flavonoids (PAF) mitigated weight loss, blood in stool, and diarrhea in DSS-induced colitis mice [PMID:40636944]
Preuve DCough and mucus
Aqueous extracts and polysaccharides significantly inhibited cough frequency and showed expectorant activity in mice and guinea pigs [PMID:26695537]
Preuve DHepatotoxicity
Triterpenes (potentillanoside A, rosamutin, kaji-ichigoside F1) exhibited in vivo hepatoprotective effects in mice [PMID:24697904]
Preuve D
Sécurité et effets indésirables
An acute toxicity study in mice using a maximum dose of 345.6 g/kg crude drug extract showed no toxic symptoms, with normal body weight, food intake, and organ function [PMID:32352405]. In a human non-interventional study of a combination product containing silverweed, adverse events were reported in 7 patients, including temporary nausea, gastric spasm, and oral burning sensation [PMID:26522087].
Synthèse des preuves
The majority of evidence is derived from in vitro studies and animal models (Level D), demonstrating significant anti-inflammatory and protective effects. There is limited human data, consisting primarily of a non-interventional study on a multi-herb combination [PMID:26522087].
Sources PubMed
1.PMID: 38855725 (2023) — The genome sequence of the silverweed cinquefoil, Potentilla anserina L., 1753. · Wellcome open research
2.PMID: 39922353 (2025) — Potentilla anserina L. polysaccharide ameliorates LPS-induced acute lung injury and relevant intestinal mucosal barrier impairment. · International journal of biological macromolecules
3.PMID: 38909825 (2024) — A systematic review on botany, ethnopharmacology, phytochemistry and pharmacology of Potentilla anserina L. · Journal of ethnopharmacology
4.PMID: 40636944 (2025) — Potentilla anserina L. flavonoids ameliorate ulcerative colitis by modulating oxidative stress, intestinal microbiota dysbiosis, and inflammatory responses. · 3 Biotech
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Polysaccharides (PAP) reduced lung water content, alleviated tissue injury, and protected against brain impairment in rat models [PMID:34243609, PMID:32298011]
Preuve DSkin damage (mask-induced)
Extract increased Aquaporin-3 and Filaggrin expression, improving skin hydration and barrier function [PMID:37762597]
(2020)
— Acute toxicity of Potentilla anserina L. extract in mice.
· Zeitschrift fur Naturforschung. C, Journal of biosciences
6.PMID: 37528998 (2023) — Enzyme-assisted extraction, characterization, and in vitro antioxidant activity of polysaccharides from Potentilla anserina L. · Frontiers in nutrition
7.PMID: 39716778 (2025) — Drift in small populations predicts mate availability and the breakdown of self-incompatibility in a clonal polyploid. · The New phytologist
8.PMID: 34288682 (2021) — Pentacyclic Triterpenoid Saponins, Poterinasides A-J, from Silverweed Cinquefoil Roots Promising Hepatoprotective and Anti-inflammatory Agents. · The Journal of organic chemistry
9.PMID: 26695537 (2016) — Antitussive and expectorant activities of Potentilla anserina. · Pharmaceutical biology
10.PMID: 36717756 (2023) — Phenols from Potentilla anserina L. Improve Insulin Sensitivity and Inhibit Differentiation in 3T3-L1 Adipocytes in Vitro. · Chemistry & biodiversity
11.PMID: 17238103 (1995) — Flavan-3-ols and flavonoids from Potentilla anserina. · Planta medica
12.PMID: 37762597 (2023) — The Protective Effects of Moisturizer Containing Potentilla anserina Extract in the Topical Treatment of Skin Damage Caused by Masks. · International journal of molecular sciences
13.PMID: 34243609 (2021) — Polysaccharide from Potentilla anserina L ameliorate pulmonary edema induced by hypobaric hypoxia in rats. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
14.PMID: 24697904 (2014) — Hepatoprotective triterpenes from traditional Tibetan medicine Potentilla anserina. · Phytochemistry
15.PMID: 26522087 (2016) — Treatment of Mild Gastrointestinal Disorders with a Herbal Combination: Results of a Non-interventional Study with Gastritol® Liquid. · Phytotherapy research : PTR
16.PMID: 32298011 (2020) — Polysaccharide extracted from Potentilla anserina L ameliorate acute hypobaric hypoxia-induced brain impairment in rats. · Phytotherapy research : PTR