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Cullen corylifolium
TCM and Ayurvedic herb that tonifies kidney yang and treats vitiligo via psoralen content.
Psoralea seed (Cullen corylifolium) is a traditional herb in TCM and Ayurveda, primarily used to tonify kidney yang and treat vitiligo. Its key active compounds include psoralen, isopsoralen, and bakuchiol, which confer photosensitizing, bone-protective, and anti-inflammatory properties. Modern research explores its applications in vitiligo therapy, bone density improvement, and psoriasis management, though clinical evidence remains limited.
Psoralen and isopsoralen are furanocoumarins that intercalate with DNA and, upon UVA exposure, form crosslinks, inhibiting cell proliferation and stimulating melanogenesis via tyrosinase activation. Bakuchiol acts as a phytoestrogen and antioxidant, promoting osteoblast differentiation through BMP-2 and Runx2 pathways, while also modulating NF-κB to reduce inflammation. Bavachin and corylifolin influence cAMP and MAPK signaling, contributing to immunomodulatory and anti-osteoporotic effects.
TCM and Ayurvedic herb that tonifies kidney yang and treats vitiligo via psoralen content.
Psoralea seed (Cullen corylifolium) is a traditional herb in TCM and Ayurveda, primarily used to tonify kidney yang and treat vitiligo. Its key active compounds include psoralen, isopsoralen, and bakuchiol, which confer photosensitizing, bone-protective, and anti-inflammatory properties. Modern research explores its applications in vitiligo therapy, bone density improvement, and psoriasis management, though clinical evidence remains limited.
Psoralen and isopsoralen are furanocoumarins that intercalate with DNA and, upon UVA exposure, form crosslinks, inhibiting cell proliferation and stimulating melanogenesis via tyrosinase activation. Bakuchiol acts as a phytoestrogen and antioxidant, promoting osteoblast differentiation through BMP-2 and Runx2 pathways, while also modulating NF-κB to reduce inflammation. Bavachin and corylifolin influence cAMP and MAPK signaling, contributing to immunomodulatory and anti-osteoporotic effects.