Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Qing Dai contains active compounds including indirubin, indigo, tryptanthrin, and isatin, which demonstrate anti-inflammatory properties. Indirubin, the primary active constituent, inhibits inflammatory signaling pathways and modulates immune cell activity. Research suggests these compounds suppress pro-inflammatory cytokines and reduce abnormal cellular proliferation, making Qing Dai particularly relevant for inflammatory skin conditions like psoriasis. The mechanism involves interference with cell cycle progression in hyperproliferative cells. Evidence level: C (preliminary clinical evidence).
Does Qing Dai interact with any medications?
Qing Dai may interact with hepatotoxic medications due to its potential for liver damage at high doses. Concurrent use with drugs metabolized by the liver, such as certain statins, acetaminophen, or antibiotics, may increase hepatotoxicity risk. Patients taking immunosuppressants should exercise caution, as Qing Dai's immunomodulatory effects could alter drug efficacy. Always consult a healthcare provider before combining Qing Dai with prescription medications. Evidence level: C.
What is the recommended dosage for Qing Dai?
The typical adult dosage for Qing Dai is 1.5-3 grams of powder daily for internal use. For topical application, the powder is mixed with a suitable vehicle such as water or oil and applied to affected areas for conditions like psoriasis or mouth ulcers. Internal use should be limited to recommended amounts due to potential hepatotoxicity at higher doses. A qualified practitioner should monitor long-term use. Evidence level: C/Traditional.
Is Qing Dai safe to take during pregnancy?
Qing Dai is contraindicated during pregnancy and should be avoided. Traditional Chinese Medicine classifies this herb as unsafe for pregnant women, as it may stimulate uterine contractions or affect fetal development. The herb's cold thermal nature in TCM theory also makes it inappropriate during pregnancy, when maintaining warmth is typically prioritized. Breastfeeding women should likewise avoid Qing Dai unless specifically directed by a qualified healthcare provider. Evidence level: Traditional/C.
What conditions does Qing Dai treat?
Qing Dai is used in Traditional Chinese Medicine for inflammatory conditions including psoriasis, mouth ulcers, fever, and mumps. Topical applications are common for skin conditions like psoriasis and oral lesions, while internal use addresses systemic inflammation and heat-related conditions. The herb's cooling and anti-inflammatory properties make it particularly useful for conditions characterized by heat and toxins in TCM theory. Evidence level: C (preliminary clinical evidence).
What are the side effects of Qing Dai?
Common side effects of Qing Dai include gastrointestinal upset such as nausea, vomiting, or diarrhea, particularly with internal use. More serious concerns involve potential liver damage at high doses, making it contraindicated for patients with pre-existing liver disease. Traditional Chinese Medicine also cautions against use in individuals with spleen or stomach cold patterns, as the herb's cooling nature may worsen digestive weakness. Evidence level: C/Traditional.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Qing Dai (Indigo naturalis) is a traditional herbal medicine derived from plants such as Isatis indigotica, used primarily for treating autoimmune conditions like psoriasis and ulcerative colitis [PMID:38301993, PMID:33317592].
Contexte
Qing Dai is a dried bluish-spruce powder derived from the aerial components of plants including Isatis indigotica (Chinese woad), Baphicacanthus cusia, and Polygonum tinctorium [PMID:35139772, PMID:38301993]. It has a historical application as a dye in ancient India, Egypt, Africa, and China [PMID:38301993].
Usages traditionnels
In Traditional Chinese Medicine (TCM), it is used for clearing heat, detoxifying blood, eliminating spots, reducing fire, and calming panic [PMID:35872288, PMID:26389352]. It has been used to treat ailments including hemoptysis, epistaxis, chest discomfort, and aphtha [PMID:38301993].
Composés actifs
Major active ingredients include lignans, indole alkaloids, and their derivatives [PMID:37789475]. Specific identified compounds include indigo, indirubin, tryptanthrin, and isatin [PMID:38948310, PMID:19296433].
Mécanisme d'action
Mechanisms include the activation of the Aryl hydrocarbon Receptor (AhR) pathway to promote mucosal healing via interleukin-22 [PMID:31034341, PMID:38948310], inhibition of NF-κB/NLRP3/IL-1β and TLR4/MYD88/NF-κB pathways [PMID:38948310], and suppression of ferroptosis by increasing antioxidant genes in the mucosa [PMID:37410250]. In psoriasis, it is thought to regulate keratinocyte proliferation and differentiation and restore epidermal barrier function [PMID:26954317].
Preuves cliniques
Preuve AUlcerative Colitis (UC)
A meta-analysis of 9 studies (299 patients) showed a pooled clinical response rate of 0.796 and a clinical remission rate of 0.668 [PMID:38006941]. In pediatric UC, 80.2% of patients achieved clinical remission within 6 months [PMID:35831249].
Preuve CPsoriasis
Chinese herbal medicine formulas containing indigo naturalis showed a higher response rate for PASI60 compared to control groups [PMID:39316667].
Preuve CAcute Promyelocytic Leukemia (APL)
The Realgar-Indigo Naturalis formula (RIF) plus all-trans-retinoic acid (ATRA) is used as a frontline care regimen in China [PMID:33614484].
Sécurité et effets indésirables
Serious adverse effects include Indigo naturalis-induced colitis [PMID:29964335, PMID:31034341] and pulmonary arterial hypertension (PAH), the latter of which is recognized in the 2022 ESC/ERS guidelines [PMID:41403416, PMID:31034341]. Indirubin may also induce hepatic injury in mice with chronic colitis via macrophage-mediated transport [PMID:40546113].
Synthèse des preuves
Evidence for the treatment of ulcerative colitis is strongest (Meta-analysis/Systematic Review), while evidence for psoriasis and leukemia is primarily based on reviews and clinical summaries.
Sources PubMed
1.PMID: 40210174 (2025) — Herbal medicine for treating psoriasis: A systematic review. · Complementary therapies in medicine
2.PMID: 38006941 (2024) — Indigo naturalis (Qing dai) for inflammatory bowel disease: A systematic review and meta-analysis. · Clinics and research in hepatology and gastroenterology
3.PMID: 29964335 (2018) — Indigo naturalis-induced colitis. · Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
4.PMID: 38068631 (2023) — Latin American Plants against Microorganisms. · Plants (Basel, Switzerland)
5.PMID: 35872288 (2022) — Psoriasis treatment using Indigo Naturalis: Progress and strategy. · Journal of ethnopharmacology
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
PMID: 37789475 (2021) — Isatis indigotica: from (ethno) botany, biochemistry to synthetic biology. · Molecular horticulture
7.PMID: 38301993 (2024) — The double-edged sword effect of indigo naturalis. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
8.PMID: 41403416 (2025) — Long-term outcomes of Qing-Dai-induced pulmonary arterial hypertension. · ERJ open research
9.PMID: 26389352 (2002) — Isatis indigotica: a review of phytochemistry, pharmacological activities and clinical applications. · The Journal of pharmacy and pharmacology
11.PMID: 33614484 (2020) — Oral Realgar-Indigo Naturalis Formula Plus Retinoic Acid for Acute Promyelocytic Leukemia. · Frontiers in oncology
12.PMID: 26954317 (2016) — A Review of Indigo Naturalis as an Alternative Treatment for Nail Psoriasis. · Journal of drugs in dermatology : JDD
13.PMID: 38948310 (2024) — Indigo Naturalis in Inflammatory Bowel Disease: mechanisms of action and insights from clinical trials. · Journal of pharmacopuncture
14.PMID: 33317592 (2020) — From natural dye to herbal medicine: a systematic review of chemical constituents, pharmacological effects and clinical applications of indigo naturalis. · Chinese medicine
15.PMID: 31034341 (2019) — Treatment with indigo naturalis for inflammatory bowel disease and other immune diseases. · Immunological medicine
16.PMID: 35831249 (2022) — Qing-Dai for pediatric ulcerative colitis multicenter survey and systematic review. · Pediatrics international : official journal of the Japan Pediatric Society
17.PMID: 37669429 (2023) — High-Quality Indigo Naturalis Obtained with Automatic Foam Separation. · ACS applied materials & interfaces
18.PMID: 37596543 (2023) — Classification of Isatis indigotica Fortune and Isatis tinctoria Linnaeus via comparative analysis of chloroplast genomes. · BMC genomics
19.PMID: 39316667 (2024) — Evidence and potential mechanism of action of indigo naturalis and its active components in the treatment of psoriasis. · Annals of medicine
20.PMID: 39154058 (2024) — Complementary and Alternative Therapies for Psoriasis. · Archives of dermatological research
21.PMID: 40756994 (2025) — Indigo naturalis for inflammatory bowel disease: evidence from animal studies and molecular mechanisms. · Frontiers in pharmacology
22.PMID: 40546113 (2025) — Macrophage-Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation. · Advanced science (Weinheim, Baden-Wurttemberg, Germany)
23.PMID: 27025363 (2016) — Computational identification and systematic classification of novel GRAS genes in Isatis indigotica. · Chinese journal of natural medicines
24.PMID: 35598366 (2022) — Pharmacological properties of indirubin and its derivatives. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
25.PMID: 32237505 (2020) — [Advances in biosynthesis of indigo in plants]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
26.PMID: 32033881 (2020) — Comparison of the anti-colitis activities of Qing Dai/Indigo Naturalis constituents in mice. · Journal of pharmacological sciences
27.PMID: 36192353 (2023) — Genome-wide analysis of AP2/ERF superfamily in Isatis indigotica. · Journal of integrative medicine
28.PMID: 35139772 (2022) — A Systemic Review for Ethnopharmacological Studies on Isatis indigotica Fortune: Bioactive Compounds and their Therapeutic Insights. · The American journal of Chinese medicine
29.PMID: 37410250 (2023) — Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis. · Journal of gastroenterology