Rang Chued (Thunbergia laurifolia): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Rang Chued work as a liver detox?

Rang Chued (Thunbergia laurifolia) contains antioxidant compounds including quercetin, kaempferol, and phenylethanoids that help protect liver cells from oxidative damage. These compounds work by neutralizing free radicals and reducing inflammation in hepatic tissues. The herb may also enhance the liver's natural detoxification pathways by supporting enzyme activity involved in toxin metabolism. Evidence level: C (preliminary research).

Does Rang Chued interact with medications?

Limited research exists on drug interactions with Thunbergia laurifolia. Due to its effects on liver detoxification pathways, Rang Chued may potentially alter how the liver metabolizes certain medications, affecting their blood levels and effectiveness. If you take prescription medications, especially those processed by the liver, consult a healthcare provider before using this herb. Evidence level: C.

What is the recommended dosage for Rang Chued?

The traditional adult dosage for Rang Chued is 15-30 grams of dried leaf daily, typically prepared as a decoction or tea. This dosage is based on traditional Thai herbal practice rather than standardized clinical trials. Dosage may vary depending on the specific preparation and intended use. Always follow product label instructions or consult a qualified herbalist for personalized guidance. Evidence level: Traditional.

Is Rang Chued safe during pregnancy and breastfeeding?

Rang Chued (Thunbergia laurifolia) is contraindicated during pregnancy and should be avoided. There is insufficient safety data regarding its use during breastfeeding, so nursing mothers should also avoid this herb. The herb's effects on detoxification pathways and potential uterine stimulation make it unsuitable for pregnant women. Consult a healthcare provider for pregnancy-safe alternatives. Evidence level: Traditional/Expert consensus.

What is Rang Chued used for in Thai traditional medicine?

Rang Chued is widely used in Thai traditional medicine as a detoxification herb and antidote for various poisonings. Primary uses include treating alcohol poisoning, drug toxicity, and food poisoning. It is also employed for fever reduction and as a hepatoprotective agent to support liver health. The herb has a long history of traditional use for these purposes, though clinical evidence remains limited. Evidence level: C.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Rang Chued (Thunbergia laurifolia) is a Thai medicinal plant recognized for its antioxidant, detoxifying, and hepatoprotective properties [PMID:36518438, 29410686].

Contexte

Thunbergia laurifolia, also known as Rang Chued or Rang-jued, is a medicinal plant from the Acanthaceae family used in Thailand [PMID:36518438, 34829549].

Usages traditionnels

It is used in traditional Thai medicine as an antidote, for decreasing body temperature (antipyretic), to treat mouth ulcers, and as an herbal tea [PMID:36518438, 38735681, 35745006].

Composés actifs

Major bioactive compounds include rosmarinic acid, caffeic acid, and vicenin-2 [PMID:38735681, 34451693]. Other identified constituents include apigenin, gallic acid, carotenoids, chlorophylls (Pheophytin a and Hydroxy Pheophytin a), iridoid glucosides (8-epi-grandifloric acid and 3'-O-beta-glucopyranosyl-stilbericoside), and 5-acetoxyfuranonapthoquinone [PMID:38790743, 12150796, 36170203].

Mécanisme d'action

The herb acts by increasing antioxidant enzyme activities (SOD1, SOD2, CAT, GPx), reducing intracellular reactive oxygen species (ROS), and modulating the p62-KEAP1-NRF2 signaling pathway [PMID:34829549, 36309371]. It also induces the detoxifying enzyme NQO-1 in liver cells [PMID:38790743] and may inhibit MMP-1, MMP-2, and MMP-9 [PMID:32326348, 29410686].

Preuves cliniques

Preuve DLead-induced renotoxicity

Leaf extracts partially recovered renotoxicity by modulating cell signaling pathways in mice [PMID:34466056]

Preuve DParaquat-induced lung and kidney injury

Aqueous leaf extract alleviated lung injury by inhibiting oxidative stress and inflammation, and ameliorated kidney injury by regulating NADPH oxidase in rats [PMID:35317802, 35399379]

Preuve DAlcohol-induced hangover

Leaf extract administered prior to ethanol increased locomotor activity and reduced blood ethanol levels and liver enzyme changes in rats [PMID:40430504]

Preuve DGestational Diabetes Mellitus (GDM)

Ethanolic extract significantly reduced blood glucose and increased insulin levels in a rat model [PMID:38941042]

Preuve DCognitive and emotional deficits

Leaf extract reduced cognitive deficits in olfactorectomized mice [PMID:25609149]

Preuve DCadmium toxicity

Sécurité et effets indésirables

Acute toxicity studies in Wistar rats using oral gavage of water, ethanol, and acetone extracts at doses up to 15,000 mg/kg did not report immediate lethal toxicity [PMID:36518438]. Chronic oral administration (30 days) at 1 and 10 g/kg did not cause addiction behavior in rats [PMID:26817209].

Grossesse et allaitement

A study in a rat model of gestational diabetes showed that T. laurifolia extract reduced blood glucose and increased insulin levels from gestation day 7 until term [PMID:38941042].

Synthèse des preuves

The current evidence consists primarily of in vitro cell studies and in vivo animal models (rats, mice, ducks, rabbits). There is a lack of human clinical trial data.

Sources PubMed

1.PMID: 36518438 (2022) — Acute and sub-chronic toxicity study of Rang Chuet (Thunbergia laurifolia Lindl.) extracts and its antioxidant activities. · Toxicology reports
2.PMID: 38790743 (2024) — Identification of Pheophytin a and Hydroxy Pheophytin a from Rang Chuet (Thunbergia laurifolia Linn.) as Potent NQO-1 Inducers in Liver Cells. · Foods (Basel, Switzerland)
3.PMID: 34829549 (2021) — Thunbergia laurifolia Leaf Extract Inhibits Glutamate-Induced Neurotoxicity and Cell Death through Mitophagy Signaling. · Antioxidants (Basel, Switzerland)
4.PMID: 34466056 (2020) — Thunbergia laurifolia leaf extract partially recovers lead-induced renotoxicity through modulating the cell signaling pathways. · Saudi journal of biological sciences
5.PMID: 31935795 (2020) — Thunbergia laurifolia Leaf Extract Increased Levels of Antioxidant Enzymes and Protected Human Cell-Lines In Vitro Against Cadmium.

Rang Chued

Sources et citations

Calculer une dose sûre de Rang Chued

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Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Grossesse et allaitement

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Rang Chued

Sources et citations

Calculer une dose sûre de Rang Chued

Plantes associées

Gmelina Arborea

Pterocarpus santalinus

Dictamnus Albus

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Grossesse et allaitement

Synthèse des preuves

Sources PubMed

Sources gouvernementales