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Rauwolfia serpentina
Ayurvedic herb source of reserpine for hypertension (historical).
Rauwolfia serpentina is an Ayurvedic herb historically used for hypertension and mental disorders, with reserpine as its primary active compound that depletes catecholamines from nerve terminals. It also contains ajmaline and ajmalicine, which contribute to antiarrhythmic and vasodilatory effects. Modern use is limited due to safety concerns, but it remains a subject of pharmacological interest.
Reserpine irreversibly inhibits the vesicular monoamine transporter (VMAT2), depleting norepinephrine, dopamine, and serotonin from presynaptic vesicles, leading to reduced sympathetic outflow and hypotension. Ajmaline acts as a class Ia antiarrhythmic by blocking sodium channels, while ajmalicine exhibits alpha-adrenergic blockade and vasodilation. These combined actions underlie the herb's antihypertensive, sedative, and antiarrhythmic properties.
Ayurvedic herb source of reserpine for hypertension (historical).
Rauwolfia serpentina is an Ayurvedic herb historically used for hypertension and mental disorders, with reserpine as its primary active compound that depletes catecholamines from nerve terminals. It also contains ajmaline and ajmalicine, which contribute to antiarrhythmic and vasodilatory effects. Modern use is limited due to safety concerns, but it remains a subject of pharmacological interest.
Reserpine irreversibly inhibits the vesicular monoamine transporter (VMAT2), depleting norepinephrine, dopamine, and serotonin from presynaptic vesicles, leading to reduced sympathetic outflow and hypotension. Ajmaline acts as a class Ia antiarrhythmic by blocking sodium channels, while ajmalicine exhibits alpha-adrenergic blockade and vasodilation. These combined actions underlie the herb's antihypertensive, sedative, and antiarrhythmic properties.