Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
How does Polygonum cuspidatum work for anti-aging?
Polygonum cuspidatum serves as the primary commercial source of trans-resveratrol, a compound researched for its potential to activate sirtuins, specifically SIRT1. These enzymes play a critical role in cellular longevity and metabolic regulation. Evidence suggests this mechanism mimics caloric restriction effects, which are associated with delayed aging processes in laboratory models (Evidence Level C). Additionally, the herb contains emodin, which may provide complementary anti-inflammatory support.
Can I take resveratrol with blood thinners like Warfarin?
No, you should avoid taking Polygonum cuspidatum if you are prescribed blood thinners like Warfarin. Resveratrol possesses natural anticoagulant properties that can increase bleeding risks when combined with prescription anticoagulants. This interaction is clinically significant and constitutes a contraindication. Patients on blood-thinning medications must consult a physician before using this supplement to avoid serious adverse events.
What is the recommended dosage for Polygonum cuspidatum extract?
The standard adult dosage for Polygonum cuspidatum extract typically ranges from 150mg to 500mg of trans-resveratrol daily. This range is commonly used to support cardiovascular health and longevity goals. Dosages exceeding the upper limit have been linked to joint pain and digestive upset in some individuals. It is advisable to take this supplement with food to enhance absorption and minimize potential gastrointestinal discomfort.
Is resveratrol safe during pregnancy or breastfeeding?
No, Polygonum cuspidatum and resveratrol supplements are considered unsafe during pregnancy and breastfeeding. The plant contains emodin, a compound with laxative properties that may stimulate uterine contractions, potentially leading to miscarriage or premature labor. Furthermore, resveratrol may have estrogenic effects that could disrupt hormonal balance during gestation. Women who are pregnant or nursing should strictly avoid this herb.
What are the common side effects of Japanese knotweed supplements?
Common side effects of Polygonum cuspidatum (Japanese knotweed) primarily involve the digestive system, including loose stools, nausea, and abdominal discomfort, largely due to the presence of emodin. Some users report headaches or joint pain, particularly when taking high doses above 500mg daily. To reduce these risks, start with a lower dose to assess tolerance and discontinue use if severe joint pain occurs.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Polygonum cuspidatum is a medicinal plant rich in resveratrol and other bioactive phenolics used in traditional medicine for inflammatory and metabolic conditions [PMID:36620922, PMID:37241822].
Contexte
Polygonum cuspidatum Sieb. et Zucc (Polygonaceae), also known as 'Huzhang', is a medicinal plant and vegetable distributed in China, Korea, and Japan [PMID:36620922, PMID:38513776]. Its dried roots and rhizomes are listed in the Chinese Pharmacopoeia [PMID:36620922, PMID:24194779].
Usages traditionnels
Used in traditional Chinese medicine to treat inflammation, hyperlipemia [PMID:36620922], cough, hepatitis, jaundice, amenorrhea, leucorrhea, arthralgia, burns, and snake bites [PMID:24194779]. It is also used for clearing heat, eliminating dampness, draining the gallbladder to relieve jaundice, removing blood stasis to alleviate pain, and resolving phlegm [PMID:34719206].
Composés actifs
The plant contains flavonoids, anthraquinones, and stilbenes [PMID:36620922]. Key bioactive constituents include resveratrol (3,5,4'-trihydroxystilbene) [PMID:22432802], polydatin (resveratrol-O3-beta-glucoside) [PMID:39334769], and emodin [PMID:27188216].
Mécanisme d'action
Resveratrol acts via cell apoptosis, antiproliferation, and anti-inflammation [PMID:22432802], and inhibits protein-tyrosine kinase (p56lck) [PMID:8277318]. Polydatin increases oxidative phosphorylation (OXPHOS) efficiency to reduce reactive oxygen species (ROS) [PMID:39334769]. Emodin inhibits NLRP3 inflammasome activation by promoting FUNDC1-mediated mitophagy and suppressing CK2-mediated phosphorylation of FUNDC1 [PMID:40520006].
Preuves cliniques
Preuve ACancer
Resveratrol is believed to work as a chemopreventive agent by inducing apoptosis and suppressing cell proliferation [PMID:22432802, PMID:25788047]
Preuve CCardiovascular Disease
Resveratrol and polydatin exert cardioprotective effects by regulating lipid metabolism and reducing oxidative stress [PMID:25151891, PMID:32480216]
Preuve CLiver Injury
Polydatin, resveratrol, and emodin alleviate cholestatic liver injury by regulating bile-acid synthesis via FXR, PXR, and BSEP, and activating Nrf2-dependent antioxidant defenses [PMID:41106787]
Preuve DInflammatory Pain
Alcohol extract of P. cuspidatum exerts analgesic effects via the MAPK/ERK signaling pathway in mouse models [PMID:37876500]
Preuve DKidney Injury
Polydatin protects against ischemia-reperfusion-induced acute kidney injury by inhibiting SETD2-mediated ferroptosis in mice [PMID:41083610]
Preuve DHyperuricemia
Sécurité et effets indésirables
Emodin, a constituent of P. cuspidatum, may lead to hepatotoxicity, kidney toxicity, and reproductive toxicity, particularly with high doses and long-term use [PMID:27188216].
Synthèse des preuves
Evidence ranges from high-level systematic reviews for anticancer potential to preclinical animal and in vitro studies for organ-specific protective effects (kidney, liver, lung).
Sources PubMed
1.PMID: 27188216 (2016) — Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics. · Phytotherapy research : PTR
3.PMID: 40520006 (2025) — Emodin Inhibits NLRP3 Inflammasome Activation and Protects Against Sepsis via Promoting FUNDC1-Mediated Mitophagy. · International journal of biological sciences
4.PMID: 36620922 (2023) — Advances for pharmacological activities of Polygonum cuspidatum - A review. · Pharmaceutical biology
5.PMID: 33459060 (2021) — Bioactive amides from Polygonum cuspidatum. · Journal of Asian natural products research
6.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
7.PMID: 39334769 (2024) — Senescence Rejuvenation through Reduction in Mitochondrial Reactive Oxygen Species Generation by Polygonum cuspidatum Extract: In Vitro Evidence. · Antioxidants (Basel, Switzerland)
8.PMID: 22432802 (2012) — Resveratrol: potential as anticancer agent. · Journal of dietary supplements
9.PMID: 41106787 (2025) — Protective effects of Polygonum cuspidatum bioactive constituents against cholestatic liver injury: A mechanistic review. · Fitoterapia
10.PMID: 25151891 (2014) — Resveratrol and cardiovascular health--promising therapeutic or hopeless illusion? · Pharmacological research
11.PMID: 8277318 (1993) — Kinase inhibitors from Polygonum cuspidatum. · Journal of natural products
12.PMID: 34808343 (2022) — Expression, purification and structural characterization of resveratrol synthase from Polygonum cuspidatum. · Protein expression and purification
13.PMID: 37876500 (2023) — Polygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway. · Drug design, development and therapy
14.PMID: 38513776 (2024) — Polygonum cuspidatum polysaccharide: A review of its extraction and purification, structure analysis, and biological activity. · Journal of ethnopharmacology
15.PMID: 36304949 (2022) — Resveratrol biosynthesis, optimization, induction, bio-transformation and bio-degradation in mycoendophytes. · Frontiers in microbiology
16.PMID: 17657351 (2007) — Antioxidant activity of extract from Polygonum cuspidatum. · Biological research
17.PMID: 24194779 (2013) — A Review of the Pharmacological Effects of the Dried Root of Polygonum cuspidatum (Hu Zhang) and Its Constituents. · Evidence-based complementary and alternative medicine : eCAM
18.PMID: 37241822 (2023) — Evaluation of the Biological Properties of an Optimized Extract of Polygonum cuspidatum Using Ultrasonic-Assisted Extraction. · Molecules (Basel, Switzerland)
19.PMID: 34719206 (2021) — Effective inhibition of coronavirus replication by Polygonum cuspidatum. · Frontiers in bioscience (Landmark edition)
20.PMID: 40538533 (2025) — Polydatin-curcumin formulation alleviates CTD-ILD-like lung injury in mice via GABBR/PI3K/AKT/TGF-β pathway. · Frontiers in pharmacology
21.PMID: 34018734 (2021) — De Novo Biosynthesis of Polydatin in Saccharomyces cerevisiae. · Journal of agricultural and food chemistry
22.PMID: 25788047 (2015) — Anti-tumor effects and cellular mechanisms of resveratrol. · Drug discoveries & therapeutics
23.PMID: 38276543 (2024) — Effects of Fermented Polygonum cuspidatum on the Skeletal Muscle Functions. · Nutrients
24.PMID: 41083610 (2025) — Polydatin Alleviated Ischemia-Reperfusion Induced Kidney Injury by Inhibiting SETD2-Mediated Ferroptosis. · Phytotherapy research : PTR
25.PMID: 31836186 (2020) — Protective effects of polydatin on multiple organ ischemia-reperfusion injury. · Bioorganic chemistry
26.PMID: 36618923 (2022) — Emodin in cardiovascular disease: The role and therapeutic potential. · Frontiers in pharmacology
27.PMID: 23862567 (2013) — Polydatin: a review of pharmacology and pharmacokinetics. · Pharmaceutical biology
28.PMID: 41365191 (2026) — Polygonum cuspidatum alleviates hyperuricemia-induced renal injury via rectifying amino acid metabolism disorders. · Phytomedicine : international journal of phytotherapy and phytopharmacology
29.PMID: 42287223 (2026) — Functional Divergence of Three Segmentally Duplicated UGT71 Enzymes Reveals Distinct Glycosylation Strategies toward Resveratrol and Emodin in Polygonum cuspidatum. · Journal of agricultural and food chemistry
30.PMID: 32480216 (2020) — Polydatin for treating atherosclerotic diseases: A functional and mechanistic overview. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie