Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Rue contains alkaloids like graveoline and volatile oils that stimulate smooth muscle contractions in the uterus, which explains its traditional use as an emmenagogue to induce menstruation (Evidence Level: Traditional). Additionally, it contains rutin, a flavonoid that strengthens capillary walls and reduces permeability. These combined actions support its historical use for delayed menses and circulatory issues, though the uterine stimulation makes it dangerous for pregnant women.
Is Rue herb safe to take during pregnancy?
Rue is unsafe during pregnancy and is strictly contraindicated (Evidence Level: C). It acts as a powerful uterine stimulant and abortifacient, meaning it can cause uterine contractions and induce miscarriage. Historical texts document its use to terminate pregnancies, and modern case reports confirm these risks. Due to the potential for fetal harm and maternal toxicity, including liver and kidney damage, it must be avoided by pregnant women.
What is the recommended dosage for Rue herb?
Due to its narrow therapeutic window, Rue requires very small doses. Traditional guidelines suggest a dosage of 0.5 to 1 gram of dried herb equivalent per day (Evidence Level: Traditional). It is often prepared as a weak infusion rather than a strong decoction. Because of the risks of hepatotoxicity and phototoxicity, internal use should be short-term and supervised by a qualified herbalist; overdose can lead to severe gastrointestinal bleeding.
Does Rue herb interact with blood thinners?
Rue has significant interaction risks, particularly with anticoagulant medications like warfarin (Evidence Level: C/Theoretical). The herb affects blood clotting and capillary strength, which may potentiate the effects of blood thinners and increase bleeding risk. Furthermore, Rue contains furanocoumarins that cause phototoxicity; combining it with other photosensitizing drugs increases skin damage risk. It should also be avoided with hepatotoxic drugs to prevent cumulative liver damage.
What are the side effects of Rue herb?
The most notable side effect of Rue is phototoxicity, causing severe skin burns or blisters upon contact with the plant followed by sun exposure (Evidence Level: C). Internal overdose can result in hepatotoxicity (liver damage), kidney failure, and gastrointestinal bleeding. Symptoms of toxicity include severe stomach pain, nausea, vomiting, and dizziness. Due to these serious risks, handling the plant requires gloves, and internal consumption demands strict adherence to safety limits.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Ruta graveolens (common rue) is a medicinal herb from the Rutaceae family used traditionally for various ailments, though it is associated with significant toxicity and phototoxicity [PMID:34443352, 17364636, 17303046].
Contexte
Ruta graveolens, also known as common rue, is a species of the citrus family (Rutaceae) primarily distributed in the Mediterranean region [PMID:34443352, 36840175].
Usages traditionnels
Traditional uses include treatment of fever caused by cold, wind-fire toothache, headache, bruises, sprains, irregular menstruation, infantile eczema [PMID:39758226], as well as use as an abortifacient, emmenagogue, and for lung diseases and microbial infections [PMID:34443352]. It is also used traditionally to treat vitiligo [PMID:34861325, 37627575].
Composés actifs
The herb contains essential oils rich in aliphatic ketones (e.g., 2-undecanone, 2-nonanone) [PMID:34443352], coumarins, furanocoumarins (such as psoralen, xanthotoxin, bergapten, and isopimpinellin) [PMID:18211259, 35326242], quinoline/furoquinoline alkaloids (e.g., graveoline, skimmianine) [PMID:18211259, 15161195], and flavonoids [PMID:18211259].
Mécanisme d'action
Certain compounds promote melanogenesis via the Akt/GSK-3β/β-catenin pathway [PMID:34861325] or by downregulating endoplasmic reticulum stress and pro-inflammatory cytokines through IL-6 regulation [PMID:37627575]. Some extracts exhibit prooxidant activity at high concentrations, which may contribute to cytocidal action in tumors [PMID:17059340].
Preuves cliniques
Preuve DVitiligo
Isolated compounds from R. graveolens promote melanin production and protect melanocytes against oxidative damage in vitro [PMID:34861325, 37627575]
Preuve DBacterial/Fungal Infections
Ethanolic extracts show bactericidal activity against staphylococci and P. acnes [PMID:37622509] and inhibit biofilm formation in MRSA [PMID:36510590]; essential oils show fungicidal/fungistatic effects against Candida species [PMID:34069001].
Preuve DTumors
Extracts demonstrated cytotoxicity against Dalton's lymphoma ascites and Ehrlich ascites carcinoma in culture and increased lifespan of tumor-bearing animals [PMID:17059340]
Preuve DFertility
Chloroform extracts showed significant anti-fertility activity in rats, with chalepensin identified as the active component acting at early stages of pregnancy [PMID:2748734]
Sécurité et effets indésirables
Ruta graveolens can cause multi-organ toxicity, including bradycardia, acute renal failure with hyperkalemia, and coagulopathy [PMID:17364636]. It is associated with phytophotodermatitis, a non-immunologic skin reaction (erythema, blisters, edema) occurring when psoralens on the skin are exposed to ultraviolet A light [PMID:17303046, 39202761, 34391344].
Grossesse et allaitement
Ruta species have been used traditionally as abortifacients [PMID:34443352], and extracts have shown significant anti-fertility activity in rats [PMID:2748734].
Synthèse des preuves
The available evidence is primarily based on in vitro studies, animal models, and case reports of toxicity; there are no high-level clinical trials (RCTs or meta-analyses) provided.
3.PMID: 18211259 (2008) — Application of chitin and chitosan as elicitors of coumarins and fluoroquinolone alkaloids in Ruta graveolens L. (common rue). · Biotechnology and applied biochemistry
4.PMID: 39758226 (2024) — Traditional Uses, Phytochemistry, Pharmacology and Toxicology of Ruta graveolens L.: A Critical Review and Future Perspectives. · Drug design, development and therapy
5.PMID: 39202761 (2024) — New Insights Concerning Phytophotodermatitis Induced by Phototoxic Plants. · Life (Basel, Switzerland)
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 36510590 (2022) — Effect of Ruta graveolens Extract on the Major Virulence Factors in Methicillin Resistant Staphylococcus aureus. · Infection and drug resistance
7.PMID: 17303046 (2007) — Rue the herb: Ruta graveolens--associated phytophototoxicity. · Dermatitis : contact, atopic, occupational, drug
8.PMID: 34861325 (2022) — Chemical constituents of Ruta graveolens L. and their melanogenic effects and action mechanism. · Fitoterapia
10.PMID: 17059340 (2006) — Anti-tumour activity of Ruta graveolens extract. · Asian Pacific journal of cancer prevention : APJCP
11.PMID: 34069001 (2021) — Colombian Essential Oil of Ruta graveolens against Nosocomial Antifungal Resistant Candida Strains. · Journal of fungi (Basel, Switzerland)
12.PMID: 35326242 (2022) — Phytochemical Characterization, and Antioxidant and Antimicrobial Properties of Agitated Cultures of Three Rue Species: Ruta chalepensis, Ruta corsica, and Ruta graveolens. · Antioxidants (Basel, Switzerland)
13.PMID: 15161195 (2004) — Phytotoxins from the leaves of Ruta graveolens. · Journal of agricultural and food chemistry
14.PMID: 37622509 (2023) — THE EFFECT OF RUTA GRAVEOLENS L. ETHANOLIC EXTRACTS ON SKIN ISOLATES OF STAPHYLOCOCCI AND PROPIONIBACTERIUM ACNES. · Wiadomosci lekarskie (Warsaw, Poland : 1960)
15.PMID: 37627575 (2023) — Ruta graveolens: Boost Melanogenic Effects and Protection against Oxidative Damage in Melanocytes. · Antioxidants (Basel, Switzerland)