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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Evolvulus alsinoides, known as Shankhpushpi, is a medicinal plant used in Ayurvedic and Unani medicine primarily as a brain tonic to enhance memory and treat neurological disorders [PMID:38250531, 19912732].
Contexte
Evolvulus alsinoides is a medicinal shrub in the Convolvulaceae family [PMID:38250531, 39357200]. Although used in ancient Indian medicine, it is an American species that was likely introduced to the region in the 1500s or 1600s [PMID:18384986].
Usages traditionnels
It is traditionally used in India and other countries for neurological disorders including amnesia, as a brain tonic, and for ailments such as asthma, epilepsy, and cardiovascular disorders [PMID:38250531, 38159824].
Composés actifs
The plant contains scopoletin (a furanocoumarin), caffeic acid, chlorogenic acid, beta-carotene, and various alkaloids, flavonoids, and phenols including quercetin [PMID:21369458, 38882856, 23662279, 23554763]. Other identified components include evolvulic acids A, B, and C, as well as kaempferol glycosides [PMID:32131634, 17473466].
Mécanisme d'action
The herb demonstrates antioxidant activity by modulating oxidative alterations in the brain and blood plasma [PMID:19748554, 25480513]. Scopoletin shows binding affinities with ERAP1, SCN3A, and COMT [PMID:38883392], while caffeic acid shows binding affinity with molecules in the insulin signaling cascade [PMID:38882856]. It also inhibits alpha-amylase and alpha-glucosidase [PMID:38882856, 32345272].
Preuves cliniques
Preuve BPrimary Hypertension
A randomized controlled trial compared a hydro-alcoholic extract (630 mg daily) to ramipril (5 mg daily) for the treatment of hypertension [PMID:38159824].
Preuve DAmnesia (Animal Model)
Methanolic extract showed nootropic activity in mice with scopolamine-induced amnesia, significantly affecting time spent in maze zones [PMID:38250536, 31049081].
Preuve DWound Healing
The plant exhibits wound healing activity, with alkaloid-enriched ointments promoting dermal wound contraction in rats [PMID:30705787, 27267555].
Preuve DDiabetes (In Vitro)
Aqueous extracts demonstrate antidiabetic potential through the inhibition of alpha-amylase and alpha-glucosidase [PMID:38882856, 32345272].
Sécurité et effets indésirables
In vivo toxicity studies in Swiss albino mice using ethanolic extracts (up to 2000 mg/kg) were conducted to assess acute and sub-acute toxicity [PMID:31049083]. Methanolic extracts triggered apoptosis in human hepatoma HepG2 cells in a concentration-dependent manner [PMID:30456198].
Synthèse des preuves
The evidence consists primarily of preclinical animal models (D), in vitro studies (D), and reviews (C), with one randomized controlled trial (B) investigating antihypertensive effects. Most cognitive and antidiabetic claims are based on animal or laboratory data.
Sources PubMed
1.PMID: 38250531 (2023) — Biochemical analysis of methanolic extract from Evolvulus alsinoides. · Bioinformation
2.PMID: 19912732 (2009) — An update on Shankhpushpi, a cognition-boosting Ayurvedic medicine. · Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
3.PMID: 38250536 (2023) — Nootropic activity of methanolic extract from Evolvulus alsinoides Linn. in mice with scopolamine-induced amnesia. · Bioinformation
4.PMID: 18384986 (2008) — Evolvulus alsinoides (Convolvulaceae): an American herb in the Old World. · Journal of ethnopharmacology
5.PMID: 30705787 (2019) — Wound Healing Activity of Plants from the Convolvulaceae Family.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 29861767 (2018) — Ayurvedic Medicine for the Treatment of Dementia: Mechanistic Aspects. · Evidence-based complementary and alternative medicine : eCAM
7.PMID: 38882856 (2024) — Phytochemical Screening and Antidiabetic Activity of Aqueous Extract of Evolvulus Alsinoides Leaves: An In Vitro and In Silico Study. · Journal of pharmacy & bioallied sciences
8.PMID: 38159824 (2024) — Evaluation of the efficacy of hydro-alcoholic extract of Evolvulus alsinoides L. for the treatment of primary hypertension - A randomized controlled trial. · Journal of ethnopharmacology
9.PMID: 30456198 (2018) — Evolvulus alsinoides methanolic extract triggers apoptosis in HepG2 cells. · Avicenna journal of phytomedicine
10.PMID: 28597435 (2016) — Micro-morphological study of Evolvulus spp. (Convolvulaceae): the old world medicinal plants. · Botanical studies
12.PMID: 31049083 (2019) — In Vivo Toxicity Study of Ethanolic Extracts of Evolvulus alsinoides & Centella asiatica in Swiss Albino Mice. · Open access Macedonian journal of medical sciences
13.PMID: 25480513 (2014) — Antioxidant activity and functional group analysis of Evolvulus alsinoides. · Chinese journal of natural medicines
14.PMID: 27175337 (2016) — Internal transcribed spacer guided multiplex PCR for species identification of Convolvulus prostratus and Evolvulus alsinoides. · Acta pharmaceutica Sinica. B
15.PMID: 21369458 (2008) — Spectrofluorimetric Estimation of Scopoletin in Evolvulus alsinoides Linn. and Convulvulus pluricaulis Choisy. · Indian journal of pharmaceutical sciences
16.PMID: 34440513 (2021) — Genome Characterization, Comparison and Phylogenetic Analysis of Complete Mitochondrial Genome of Evolvulus alsinoides Reveals Highly Rearranged Gene Order in Solanales. · Life (Basel, Switzerland)
17.PMID: 38883392 (2024) — Exploring the neuropharmacological properties of scopoletin-rich Evolvulus alsinoides extract using in-silico and in-vitro methods. · American journal of translational research
18.PMID: 31049081 (2019) — Neuroprotective Activity of Evolvulus alsinoides & Centella asiatica Ethanolic Extracts in Scopolamine-Induced Amnesia in Swiss Albino Mice. · Open access Macedonian journal of medical sciences
19.PMID: 23554763 (2012) — Secondary metabolite credentials of Evolvulus alsinoides by high performance thin layer chromatography (HPTLC). · Journal of biomedical research
20.PMID: 32345272 (2020) — In vitro enzyme inhibitory and cytotoxic studies with Evolvulus alsinoides (Linn.) Linn. Leaf extract: a plant from Ayurveda recognized as Dasapushpam for the management of Alzheimer's disease and diabetes mellitus. · BMC complementary medicine and therapies
21.PMID: 33321899 (2020) — Indian Medicinal Herbs and Formulations for Alzheimer's Disease, from Traditional Knowledge to Scientific Assessment. · Brain sciences
22.PMID: 25694742 (2015) — GC-MS analysis of bioactive compounds from the whole plant ethanolic extract of Evolvulus alsinoides (L.) L. · Journal of food science and technology
23.PMID: 34539121 (2021) — Complete chloroplast genome of the medicinal plant Evolvulus alsinoides: comparative analysis, identification of mutational hotspots and evolutionary dynamics with species of Solanales. · Physiology and molecular biology of plants : an international journal of functional plant biology
24.PMID: 32131634 (2021) — Isolation of evolvulic acids B and C, two new components of crude resin glycoside fraction from Evolvulus alsinoides. · Natural product research
25.PMID: 17473466 (2007) — Anti-stress constituents of Evolvulus alsinoides: an ayurvedic crude drug. · Chemical & pharmaceutical bulletin
26.PMID: 21846173 (2011) — Nootropic, anxiolytic and CNS-depressant studies on different plant sources of shankhpushpi. · Pharmaceutical biology
27.PMID: 39357200 (2024) — Carbon dot unravels accumulation of triterpenoid in Evolvulus alsinoides hairy roots culture by stimulating growth, redox reactions and ANN machine learning model prediction of metabolic stress response. · Plant physiology and biochemistry : PPB
28.PMID: 23662279 (2013) — Antioxidant markers based TLC-DPPH differentiation on four commercialized botanical sources of Shankhpushpi (A Medhya Rasayana): A preliminary assessment. · Journal of advanced pharmaceutical technology & research
29.PMID: 27267555 (2016) — Dermal wound healing potency of single alkaloid (betaine) versus standardized crude alkaloid enriched-ointment of Evolvulus alsinoides. · Pharmaceutical biology
30.PMID: 26621800 (2016) — In vitro propagation and cell cultures of memory tonic herb Evolvulus alsinoides: a best source for elicited production of scopoletin. · Applied microbiology and biotechnology