Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Shi Chang Pu works primarily through its active compounds, alpha-asarone and beta-asarone, which are volatile oils capable of crossing the blood-brain barrier. These compounds are believed to exert neuroprotective effects by modulating neurotransmitter activity and reducing oxidative stress in neural tissues. In Traditional Chinese Medicine, this mechanism is described as 'opening the orifices' to clear the mind and resolve phlegm obstruction affecting the senses. Current evidence supports these neuroprotective properties, though human clinical trials are limited (Evidence level: C).
Does Shi Chang Pu interact with prescription medications?
Yes, Shi Chang Pu has potential drug interactions, particularly with central nervous system (CNS) depressants and anticonvulsants. Because the herb possesses sedative and antiepileptic properties, combining it with medications like barbiturates or benzodiazepines may potentiate drowsiness or CNS depression. Additionally, compounds in Acorus tatarinowii may affect cytochrome P450 enzymes, potentially altering the metabolism of various pharmaceuticals. Patients taking anticoagulants or seizure medication should exercise caution (Evidence level: C/Theoretical).
What is the standard dosage for Shi Chang Pu?
The standard adult dosage for Shi Chang Pu is 3 to 6 grams daily when prepared as a decoction. This amount is traditionally used to address cognitive issues, epilepsy, and mental confusion. For granulated extracts, dosage should follow manufacturer guidelines, as concentrations vary. It is crucial to adhere to recommended amounts because high doses can cause gastrointestinal irritation. Due to the presence of beta-asarone, prolonged use of high doses should be avoided (Evidence level: Traditional).
Is Shi Chang Pu safe during pregnancy?
No, Shi Chang Pu is considered unsafe during pregnancy. The herb contains beta-asarone, a compound associated with potential carcinogenicity and toxicity, which poses risks to fetal development. Furthermore, Traditional Chinese Medicine classifies this herb as 'acrid, warm, and opening,' properties that are generally contraindicated during pregnancy because they may stimulate uterine contractions. Women who are breastfeeding should also avoid this herb due to insufficient safety data (Evidence level: C).
What are the side effects of taking Acorus tatarinowii?
Common side effects of Acorus tatarinowii (Shi Chang Pu) include nausea and vomiting, particularly when taken in high doses or on an empty stomach. These gastrointestinal reactions are caused by the irritation of the volatile oils found in the rhizome. The herb is contraindicated for individuals with Yin deficiency with heat, as its warming and drying properties may exacerbate symptoms like dry mouth or night sweats. Long-term use of high doses is discouraged due to potential toxicity concerns (Evidence level: Traditional).
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Shi Chang Pu (Acorus tatarinowii) is a traditional Chinese medicinal plant used primarily for treating brain and nervous system diseases [PMID:37299001]. Its volatile oils are noted for their ability to cross the blood-brain barrier and provide antidepressant and neuroprotective effects [PMID:33316383, PMID:26487858].
Contexte
Acorus tatarinowii Schott is a natural medicinal plant whose dried rhizome is widely used in traditional Chinese medicine [PMID:37299001, PMID:41167569]. It is characterized as a slowly evolved monocot with a complex chromosomal structural mitogenome [PMID:35835857, PMID:37774807].
Usages traditionnels
It is traditionally used to treat depression, epilepsy, fever, dizziness, heartache, stomachache, amnesia, and consciousness disorders [PMID:37299001, PMID:37007031]. It is specifically recognized for 'opening the orifices and transforming phlegm' (Kai-Qiao-Huo-Tan) and 'reviving the mind and enhancing intelligence' (Xing-Shen-Yi-Zhi) [PMID:40245967, PMID:41167569].
Composés actifs
More than 160 compounds have been identified, including phenylpropanoids, terpenoids, lignans, flavonoids, alkaloids, amides, and organic acids [PMID:37299001]. Major active components include alpha-asarone, beta-asarone, eugenol, and methyl isoeugenol [PMID:38039902, PMID:26487858, PMID:40228641, PMID:39276863].
Mécanisme d'action
Mechanisms include the activation of the PI3K/AKT pathway to improve insulin resistance [PMID:39486109], the cAMP/PKA/CREB pathway to improve cognitive impairment [PMID:38039902], and the Nrf2/NQO1/HO-1 signaling pathway to suppress NLRP3 inflammasome-mediated pyroptosis [PMID:40228641]. It also inhibits neuroinflammation via the p38 MAPK/NLRP3/STAT3 pathway [PMID:41079740] and suppresses NLRP3 inflammasome activation in AD models [PMID:36774844].
Preuves cliniques
Preuve AAlzheimer's Disease
Combination of A. tatarinowii and Polygala tenuifolia was evaluated for clinical efficacy and safety [PMID:38283842]; volatile oils improved cognitive function and reduced neuronal loss in animal models [PMID:41167569, PMID:39486109].
Preuve CDepression
Volatile oils are reported to have antidepressant effects with little toxicity [PMID:33316383]; used in combination with Polygalae Radix for post-stroke depression [PMID:41763619].
Preuve DVascular Dementia
Beta-asarone improves learning and memory and alleviates autophagy in mice via the cAMP/PKA/CREB pathway [PMID:38039902].
Preuve DParkinson's Disease
Inhalation of essential oil alleviated dyskinesia in rat models through regulation of neuroinflammation [PMID:40245967].
Preuve DNeuropathic Pain/Migraine
Alpha-asarone alleviates cutaneous hyperalgesia by inhibiting hyperexcitability and neurogenic inflammation via TLR4/NF-kB/NLRP3 signaling [PMID:39276863].
Preuve B
Sécurité et effets indésirables
Volatile oils are reported to have little toxicity and side effects [PMID:33316383].
Posologie et administration
Administration methods mentioned in studies include aromatic inhalation (olfactory therapy) [PMID:40607608, PMID:38772184] and the use of crushed leaf powder or rhizome extracts [PMID:38892521]. No PubMed data available. Consult a healthcare provider.
Synthèse des preuves
The evidence is primarily based on preclinical animal models (D) and systematic reviews (A/C). There is strong laboratory evidence for neuroprotective and anti-inflammatory effects, with emerging clinical trial protocols for cognitive impairment.
Sources PubMed
1.PMID: 33316383 (2021) — Natural volatile oils derived from herbal medicines: A promising therapy way for treating depressive disorder. · Pharmacological research
2.PMID: 37299001 (2023) — Acorus tatarinowii Schott: A Review of Its Botany, Traditional Uses, Phytochemistry, and Pharmacology. · Molecules (Basel, Switzerland)
3.PMID: 38039902 (2024) — β-asarone improves cognitive impairment and alleviates autophagy in mice with vascular dementia via the cAMP/PKA/CREB pathway. · Phytomedicine : international journal of phytotherapy and phytopharmacology
4.PMID: 36581573 (2022) — Research progress on mechanism of Chinese Kaiqiao herbs in management of neuropathic pain. · Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
5.PMID: 40578036 (2025) — Therapeutic mechanisms of Acorus tatarinowii and its bioactive compounds in cardiovascular diseases: A comprehensive review.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
A clinical trial protocol is established to evaluate the efficacy of A. tatarinowii volatile oil as herbal olfactory therapy [PMID:40607608].
· Phytomedicine : international journal of phytotherapy and phytopharmacology
6.PMID: 37573807 (2023) — Neurovascular glial unit: A target of phytotherapy for cognitive impairments. · Phytomedicine : international journal of phytotherapy and phytopharmacology
7.PMID: 40228641 (2025) — Methyl isoeugenol suppresses NLRP3 inflammasome-mediated pyroptosis via activation of Nrf2/NQO1/HO-1 signaling in cerebral ischemia-reperfusion injury. · Biochemical pharmacology
8.PMID: 38283842 (2023) — Polygala tenuifolia and Acorus tatarinowii in the treatment of Alzheimer's disease: a systematic review and meta-analysis. · Frontiers in pharmacology
9.PMID: 26487858 (2015) — Protective effects of components of the Chinese herb grassleaf sweetflag rhizome on PC12 cells incubated with amyloid-beta42. · Neural regeneration research
10.PMID: 39486109 (2024) — The volatile oil of Acorus tatarinowii Schott ameliorates Alzheimer's disease through improving insulin resistance via activating the PI3K/AKT pathway. · Phytomedicine : international journal of phytotherapy and phytopharmacology
11.PMID: 40245967 (2025) — Inhalation of Acori Tatarinowii Rhizoma essential oil alleviates dyskinesia in Parkinson's disease rats through the regulation of neuroinflammation. · Journal of ethnopharmacology
12.PMID: 41167569 (2026) — Acorus tatarinowii Schott attenuates Alzheimer's disease via neuronal ferroptosis inhibition: A synergistic network pharmacology and multi-omics profiling study. · Journal of ethnopharmacology
13.PMID: 41763619 (2026) — Exploring the intervention mechanism of Acori Tatarinowii Rhizoma-Polygalae Radix herb pair on post-stroke depression based on multi-omics analysis. · Journal of ethnopharmacology
14.PMID: 38892521 (2024) — New Value of Acorus tatarinowii/gramineus Leaves as a Dietary Source for Dementia Prevention. · Nutrients
15.PMID: 41079740 (2025) — The volatile oil of Acorus tatarinowii schott significantly attenuates neuroinflammatory damage in a rat model of tourette syndrome by inhibiting the p38 MAPK/NLRP3/STAT3 signaling pathway. · Frontiers in pharmacology
16.PMID: 36628348 (2022) — Therapeutic Potential of Active Components from Acorus gramineus and Acorus tatarinowii in Neurological Disorders and Their Application in Korean Medicine. · Journal of pharmacopuncture
17.PMID: 40607608 (2025) — The Therapeutic Effects of Acorus Tatarinowii Volatile Oil and Electroacupuncture in Post-Stroke Cognitive Impairment Patients: A Clinical Trial Protocol. · Brain and behavior
18.PMID: 38772184 (2024) — Molecular mechanism of Chang Shen Hua volatile oil modulating brain cAMP-PKA-CREB pathway to improve depression-like behavior in rats. · Phytomedicine : international journal of phytotherapy and phytopharmacology
19.PMID: 37774807 (2024) — Multi-Chromosomal mitochondrial genome of medicinal plant Acorus tatarinowii (Acoraceae): Firstly reported from Acorales Order. · Gene
20.PMID: 36774844 (2023) — Essential oil of Acorus tatarinowii Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3 × Tg-AD transgenic mice. · Phytomedicine : international journal of phytotherapy and phytopharmacology
21.PMID: 39276863 (2024) — Alpha-asarone alleviates cutaneous hyperalgesia by inhibiting hyperexcitability and neurogenic inflammation via TLR4/NF-κB/NLRP3 signaling pathway in a female chronic migraine rat model. · Neuropharmacology
22.PMID: 38821245 (2024) — Acorus tatarinowii oils exert protective effects on microglia-mediated inflammatory injury via restoring gut microbiota composition in experimental stroke rats. · Brain research bulletin
23.PMID: 25206642 (2013) — Huoxue Rongluo Tablet reduces matrix metalloproteinase-9 expression in infarcted brain tissue. · Neural regeneration research
24.PMID: 37007031 (2023) — Acori Tatarinowii Rhizoma: A comprehensive review of its chemical composition, pharmacology, pharmacokinetics and toxicity. · Frontiers in pharmacology
25.PMID: 35835857 (2022) — The slow-evolving Acorus tatarinowii genome sheds light on ancestral monocot evolution. · Nature plants
26.PMID: 37774564 (2023) — Functional analysis of a dirigent protein AtsDIR23 in Acorustatarinowii. · Journal of plant physiology
27.PMID: 40337511 (2025) — Volatile oil of Acori tatarinowii rhizoma: potential candidate drugs for mitigating dementia. · Frontiers in pharmacology
28.PMID: 26844931 (2016) — Ultra high performance liquid chromatography with mass spectrometry for the rapid analysis and global characterization of multiple constituents from Zibu Piyin Recipe. · Journal of separation science