Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Teucrium polium, also known as felty germander, is a medicinal plant from the Lamiaceae family used traditionally for diabetes and gastrointestinal issues [PMID:36186937, PMID:34986708]. It exhibits a range of biological activities, including antioxidant, antimicrobial, and hypoglycemic effects [PMID:36186937, PMID:34850466].
Contexte
Teucrium polium L. (syn Teucrium capitatum L. or felty germander) is a member of the Lamiaceae family widely distributed across Mediterranean countries, southwestern Asia, Europe, and North Africa [PMID:36186937, PMID:22344867].
Usages traditionnels
In traditional Iranian medicine (TIM), it is used to treat abdominal pain, indigestion, common cold, and type 2 diabetes [PMID:36186937, PMID:22344867]. Other traditional uses include applications as an antifungal, antipyretic, antispasmodic, and antibacterial agent [PMID:34850466], as well as for rheumatism [PMID:22344867].
Composés actifs
The plant contains terpenes, terpenoids (including neo-clerodane diterpenoids), and flavonoids [PMID:36186937, PMID:34986708]. Specific identified compounds include germacrene D, t-cadinol, alpha-pinene, carvacrol, bicyclogermacrene, alpha-pinene, and limonene [PMID:35268662], as well as E-nerolidol, geranyl acetone, and beta-caryophyllene [PMID:41038919].
Mécanisme d'action
T. polium has been shown to reduce glucose levels via an insulin-independent pathway [PMID:36404824]. It may improve endothelial dysfunction by regulating eNOS and VCAM-1 gene expression [PMID:29864938] and exhibits xanthine oxidase inhibitory activity [PMID:37828678].
Preuves cliniques
Preuve BDiabetic foot ulcers
Topical T. polium ointment combined with standard treatment accelerated the healing of grade 1 or 2 diabetic foot ulcers [PMID:34719966]
Preuve DType 2 Diabetes
Aqueous extract significantly reduced glucose levels in diabetic rats [PMID:36404824]
Preuve DNeurodegeneration/Alzheimer's
Preventive efficacy against amyloid beta-induced aberrant neuronal activity in the hippocampus and basolateral amygdala of rats [PMID:40148951]
Preuve DHepatotoxicity
Ethyl acetate extract showed protective effects against carbon tetrachloride-induced liver cirrhosis in rats [PMID:35888180]
Sécurité et effets indésirables
T. polium has been clearly linked to cases of acute liver failure due to its terpenoid content [PMID:18318821]. A case report described a 68-year-old woman who developed diabetic ketoacidosis, complete heart block, and acute liver and kidney damage after consuming large amounts of the plant [PMID:38694375].
Synthèse des preuves
The evidence consists primarily of in vitro studies, animal models (rats), and one randomized clinical trial for topical wound healing. While promising for metabolic and neuroprotective effects, there is a significant safety warning regarding hepatotoxicity and acute systemic toxicity with high doses.
Sources PubMed
1.PMID: 39055209 (2024) — Encapsulation of felty germander (Teucrium polium L.) extract using the freeze-drying method. · Food science & nutrition
2.PMID: 36186937 (2022) — Teucrium polium L: An updated review of phytochemicals and biological activities. · Avicenna journal of phytomedicine
3.PMID: 34850466 (2021) — Therapeutics studies and biological properties of Teucrium polium (Lamiaceae). · BioFactors (Oxford, England)
4.PMID: 34986708 (2022) — A review of the phytochemistry, ethnopharmacology and biological activities of Teucrium genus (Germander). · Natural product research
5.PMID: 38257059 (2024) — Physicochemical and Sensory Stability Evaluation of Gummy Candies Fortified with Mountain Germander Extract and Prebiotics.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 34788947 (2022) — Formulation and characterization of liposomal encapsulated systems of bioactive ingredients from traditional plant mountain germander (Teucrium montanum L.) for the incorporation into coffee drinks. · Food chemistry
7.PMID: 37375165 (2023) — Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia. · Molecules (Basel, Switzerland)
8.PMID: 33776756 (2020) — Ethnomedicinal Plants of Hasankeyf (Batman-Turkey). · Frontiers in pharmacology
9.PMID: 37852098 (2023) — LC-MS based metabolic profiling and wound healing activity of a chitosan nanoparticle-loaded formula of Teucrium polium in diabetic rats. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
10.PMID: 36404824 (2022) — Aqueous extract of Teucrium polium ameliorates diabetes and induced-prostatic complication. · Journal of diabetes and metabolic disorders
11.PMID: 27776515 (2016) — Protective effects of hydroponic Teucrium polium on hippocampal neurodegeneration in ovariectomized rats. · BMC complementary and alternative medicine
12.PMID: 22344867 (2012) — Phytochemistry and medicinal properties of Teucrium polium L. (Lamiaceae). · Phytotherapy research : PTR
13.PMID: 40148951 (2025) — Teucrium Polium ameliorates amyloid β-induced brain network disorders in rats: electrophysiological and behavioral studies. · BMC complementary medicine and therapies
14.PMID: 34719966 (2024) — Topical Administration of Teucrium polium on Diabetic Foot Ulcers Accelerates Healing: A Placebo-Controlled Randomized Clinical Study. · The international journal of lower extremity wounds
15.PMID: 35268662 (2022) — Teucrium polium (L.): Phytochemical Screening and Biological Activities at Different Phenological Stages. · Molecules (Basel, Switzerland)
16.PMID: 35053127 (2022) — Teucrium polium: Potential Drug Source for Type 2 Diabetes Mellitus. · Biology
17.PMID: 37828678 (2024) — A Review of Medicinal Plants and Phytochemicals for the Management of Gout. · Current rheumatology reviews
18.PMID: 18318821 (2008) — Hepatotoxic slimming aids and other herbal hepatotoxins. · Journal of gastroenterology and hepatology
19.PMID: 31478410 (2020) — Topical Application of Teucrium polium Can Improve Wound Healing in Diabetic Rats. · The international journal of lower extremity wounds
20.PMID: 41038919 (2025) — Assessing Teucrium polium L. from chemical profiling to antioxidant, anticancer, α-amylase, and lipase activities. · Scientific reports
21.PMID: 34287978 (2021) — Teucrium polium extract-loaded solid lipid nanoparticles: A design and in vitro anticancer study. · Journal of food biochemistry
22.PMID: 30353557 (2019) — Teucrium polium attenuates carbon tetrachloride-induced toxicity in the male reproductive system of rats. · Andrologia
23.PMID: 35888180 (2022) — Pharmacokinetics and Therapeutic Potential of Teucrium polium against Liver Damage Associated Hepatotoxicity and Oxidative Injury in Rats: Computational, Biochemical and Histological Studies. · Life (Basel, Switzerland)
24.PMID: 37597789 (2023) — Screening of the phytochemical constituents of Teucrium polium extract and evaluation of their prophylactic role against the oxidative damage and cytotoxicity of Aflatoxin B1 in rats. · Toxicon : official journal of the International Society on Toxinology
25.PMID: 29263631 (2017) — Teucrium polium-induced Vasorelaxation Mediated by Endothelium-dependent and Endothelium-independent Mechanisms in Isolated Rat Thoracic Aorta. · Pharmacognosy research
26.PMID: 29670848 (2018) — Teucrium polium Extract Enhances the Anti-Angiogenesis Effect of Tranilast on Human Umbilical Vein Endothelial Cells. · Advanced pharmaceutical bulletin
27.PMID: 38694375 (2024) — Teucrium polium: new toxic effects added to the literature: a case report. · Annals of medicine and surgery (2012)
28.PMID: 29864938 (2018) — Teucrium polium improves endothelial dysfunction by regulating eNOS and VCAM-1 genes expression and vasoreactivity in diabetic rat aorta. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
29.PMID: 41227593 (2025) — Development and Structural Characterization of Pullulan/Lecithin/Zein Composite Nanofibers Loaded with Mountain Germander (Teucrium montanum) Polyphenolic Extract. · Foods (Basel, Switzerland)
30.PMID: 36479862 (2023) — A comprehensive review on medicinal plants possessing antioxidant potential. · Clinical and experimental pharmacology & physiology