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Valeriana officinalis subsp. tiliifolia
A calming sedative herb used in Tibetan medicine for sleep disorders and nervous conditions.
Tibetan Valerian (Valeriana officinalis subsp. tiliifolia) is a sedative herb traditionally used in Tibetan medicine for insomnia, anxiety, and nervous tension. Its primary active compounds include valerenic acid, isovaleric acid, and valepotriates, which modulate GABAergic and other neurotransmitter pathways. Clinical evidence supports its use as a sedative and anxiolytic, with a recommended nightly dose of 300–600 mg of standardized extract.
Valerenic acid acts as a positive allosteric modulator of GABA-A receptors, enhancing chloride ion conductance and promoting neuronal inhibition. Isovaleric acid and valepotriates contribute to sedative effects via interaction with adenosine receptors and inhibition of voltage-gated calcium channels. Additionally, flavonoids in the herb may provide mild anxiolytic effects through modulation of the serotonergic system. These combined actions result in reduced neuronal excitability and promotion of sleep.
A calming sedative herb used in Tibetan medicine for sleep disorders and nervous conditions.
Tibetan Valerian (Valeriana officinalis subsp. tiliifolia) is a sedative herb traditionally used in Tibetan medicine for insomnia, anxiety, and nervous tension. Its primary active compounds include valerenic acid, isovaleric acid, and valepotriates, which modulate GABAergic and other neurotransmitter pathways. Clinical evidence supports its use as a sedative and anxiolytic, with a recommended nightly dose of 300–600 mg of standardized extract.
Valerenic acid acts as a positive allosteric modulator of GABA-A receptors, enhancing chloride ion conductance and promoting neuronal inhibition. Isovaleric acid and valepotriates contribute to sedative effects via interaction with adenosine receptors and inhibition of voltage-gated calcium channels. Additionally, flavonoids in the herb may provide mild anxiolytic effects through modulation of the serotonergic system. These combined actions result in reduced neuronal excitability and promotion of sleep.