Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Tongkat Ali (Eurycoma longifolia) is a Southeast Asian shrub used traditionally for various conditions, including sexual dysfunction and malaria [PMID:39527684, PMID:26978330]. It is frequently marketed as a testosterone booster and ergogenic aid [PMID:39527684, PMID:22738233].
Contexte
Eurycoma longifolia, also known as Long Jack or Malaysian Ginseng, is a flowering, slow-growing shrubby tree native to Southeast Asia, including Indonesia, Malaysia, Vietnam, Cambodia, Myanmar, Laos, and Thailand [PMID:39527684, PMID:26978330, PMID:39701690].
Usages traditionnels
Traditionally, the leaves, roots, and bark are used to treat diabetes, arthritis, liver diseases, malaria, dysentery, erectile dysfunction, high blood pressure, diarrhea, fever, anxiety, and as an aphrodisiac [PMID:39527684, PMID:26978330, PMID:20434529].
Composés actifs
The plant contains bioactive compounds including quassinoids (notably eurycomanone, eurycomoside, eurycolactone, and eurycomalactone), canthin-6-one alkaloids, tirucallane triterpenes, squalene derivatives, bioactive steroids, and cinnamates [PMID:20434529, PMID:36687023, PMID:36781893, PMID:25914245].
Mécanisme d'action
Certain quassinoids, beta-carboline, and canthin-6-one alkaloids act as NF-kappaB inhibitors [PMID:24467387]. In prostate cancer cell lines, root extract appears to induce apoptosis via the PTEN/P13k/Akt pathway [PMID:38566865].
Preuves cliniques
Preuve AErectile Dysfunction
A meta-analysis of RCTs found no significant difference in the mean change of IIEF-5 scores between Tongkat Ali and placebo at week 12 [PMID:26365449].
Preuve ASerum Total Testosterone
A systematic review of testosterone boosters indicated that most, including Eurycoma longifolia, fail to significantly increase total testosterone [PMID:37697053].
Preuve CAthletic Performance
Research on endurance cycling and running performance reported no significant improvement after supplementation [PMID:22738233].
Preuve BAndrogen Deficiency of Aging Males (ADAM)
A 6-month RCT observed improvements in erectile function with both concurrent training and Eurycoma longifolia supplementation [PMID:33541567].
Sécurité et effets indésirables
Reports of clinically apparent liver injury have appeared in bodybuilders [PMID:39527684], and a case report detailed acute liver injury with jaundice and elevated enzymes following use [PMID:38646387]. Conversely, a rat study on infused coffee showed no clinical signs of toxicity [PMID:33066137].
Synthèse des preuves
Evidence is mixed; while some individual trials and reviews suggest benefits for sexual function and testosterone, systematic reviews and meta-analyses have failed to show significant efficacy for erectile dysfunction or total testosterone increase.
Sources PubMed
1.PMID: 39527684 (2012) — Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials. · CITED REFERENCE
2.PMID: 33541567 (2021) — A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males (ADAM). · Maturitas
3.PMID: 37697053 (2024) — Do "testosterone boosters" really increase serum total testosterone? A systematic review. · International journal of impotence research
4.PMID: 35845951 (2022) — A Systematic Review on Antimicrobial and Antiparasitic Activity of Eurycoma longifolia Jack (Tongkat Ali). · BioMed research international
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization.
· Nature communications
6.PMID: 26365449 (2015) — Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: systematic review and meta-analysis of randomized controlled trials. · Complementary therapies in medicine
7.PMID: 20434529 (2010) — Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. · Fitoterapia
8.PMID: 26978330 (2016) — Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology. · Molecules (Basel, Switzerland)
9.PMID: 34989200 (2021) — Anticancer Activity of Pasak Bumi Root Extract (Eurycoma longifolia Jack) on Raji Cells. · Pakistan journal of biological sciences : PJBS
10.PMID: 39701690 (2024) — [Literature research and discussion on properties of a new oversea-introduced traditional Chinese medicine Malaysian ginseng(Tongkat Ali)]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
11.PMID: 26082155 (2015) — Tongkat Ali (Eurycoma longifolia): a possible therapeutic candidate against Blastocystis sp. · Parasites & vectors
13.PMID: 22738233 (2012) — Herbs in exercise and sports. · Journal of physiological anthropology
14.PMID: 38566865 (2024) — Unveiling the Anticancer Potential of Pasak Bumi (Eurycoma Longifolia Jack) Root Extract in Prostate Cancer Treatment. · Medical archives (Sarajevo, Bosnia and Herzegovina)
15.PMID: 38646387 (2024) — A Rare Case of Tongkat Ali-Induced Liver Injury: A Case Report. · Cureus
16.PMID: 28721818 (2018) — Eurycoma longifolia, A Potential Phytomedicine for the Treatment of Cancer: Evidence of p53-mediated Apoptosis in Cancerous Cells. · Current drug targets
17.PMID: 36781893 (2023) — Integrated comparative metabolite profiling via NMR and GC-MS analyses for tongkat ali (Eurycoma longifolia) fingerprinting and quality control analysis. · Scientific reports
18.PMID: 23419023 (2013) — An evidence-based systematic review of tongkat ali (Eurycoma longifolia) by the Natural Standard Research Collaboration. · Journal of dietary supplements
19.PMID: 34987621 (2021) — Safety of Eurycoma longifolia (Tongkat Ali) root extract as a novel food pursuant to Regulation (EU) 2015/2283. · EFSA journal. European Food Safety Authority
20.PMID: 36687023 (2023) — A Multifaceted Review of Eurycoma longifolia Nutraceutical Bioactives: Production, Extraction, and Analysis in Drugs and Biofluids. · ACS omega
21.PMID: 24467387 (2014) — NF-κB inhibitors from Eurycoma longifolia. · Journal of natural products
22.PMID: 39369924 (2025) — Metabolome classification of Tongkat Ali (Eurycoma longifolia jack) and its commercial products via UHPLC-QTOF-MS-MS and its protective effect against 5-flurouracil-Induced testicular toxicity in male rats. · Journal of ethnopharmacology
23.PMID: 19919052 (2009) — Quassinoids from Eurycoma longifolia. · Journal of natural products
24.PMID: 37968729 (2023) — Eurycoma longifolia (Tongkat Ali) enhances wakefulness during active periods but facilitates sleep during resting periods in C57BL/6 mice. · The European journal of neuroscience
25.PMID: 25914245 (2015) — Simultaneous quantitation of six major quassinoids in Tongkat Ali dietary supplements by liquid chromatography with tandem mass spectrometry. · Journal of separation science
26.PMID: 39055967 (2024) — Eurycoma longifolia (Tongkat Ali) supplementation enhances sleep and wake consolidation in wild-type, but not in narcoleptic mice. · Sleep advances : a journal of the Sleep Research Society
27.PMID: 10803359 (2000) — Effects of Eurycoma longifolia Jack (Tongkat Ali) on the initiation of sexual performance of inexperienced castrated male rats. · Experimental animals