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TM
Not CommonRésumée par IA
Tropaeolum Majus herbe
Tropaeolum majus
traitement des infections urinaires dans la médecine populaire européenne
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Tropaeolum majus (garden nasturtium) is a medicinal plant native to South America containing bioactive compounds with antimicrobial, anti-inflammatory, and antioxidant properties [PMID:29766690, PMID:27161402].
Contexte
Tropaeolum majus L., belonging to the family Tropaeolaceae, is an edible flower plant used for ornamental, medicinal, and food purposes [PMID:29766690, PMID:35336212, PMID:35465202].
Usages traditionnels
It has been used as a disinfectant, an antibiotic, and for wound healing [PMID:28659749]. It is also traditionally consumed and used in popular medicine [PMID:36615228].
Composés actifs
Key compounds include benzyl glucosinolate and its breakdown product benzyl isothiocyanate (BITC) [PMID:38792178, PMID:36816870, PMID:33862976]. Other bioactive constituents include anthocyanins, polyphenols, vitamin C, isoquercitrin, chlorogenic acid, and phylloxanthobilins [PMID:29766690, PMID:38843802, PMID:36293253]. It is also a source of micro elements (potassium, phosphorus, calcium, magnesium) and macro elements (zinc, copper, iron) [PMID:29766690].
Mécanisme d'action
The herb dually blocks the COX and LOX pathways in primary human immune cells [PMID:27161402]. Phylloxanthobilins exhibit anti-inflammatory effects via COX-1 and COX-2 enzyme inhibition [PMID:38843802]. In combination with low-dose gamma radiation, it suppresses liver carcinoma progression via the EGFR-HER2 signaling pathway and enhances proapoptotic markers (caspase-3 and Bax) while inhibiting the anti-apoptotic factor BCl2 [PMID:35834717].
Preuves cliniques
Preuve BAcute Bronchitis
A combination of Tropaeolum majus herb and Armoracia rusticana root showed a statistically significant accelerated healing of bronchitis symptoms after three days compared to placebo [PMID:37167822]
Preuve CUncomplicated Urinary Tract Infections (UTI) and Respiratory Infections
Isothiocyanates from nasturtium have demonstrated positive results and good compatibility in the therapy of uncomplicated UTI and respiratory infections, and are recommended in the German S3 guideline for recurrent UTI prophylaxis [PMID:32789672]
Preuve BLipid Regulator Prostaglandin E2
In a crossover study of healthy females, nasturtium intervention containing BITC resulted in an increase in mean PGE2 levels in serum samples and ex vivo stimulated peripheral blood mononuclear cells [PMID:37599682]
Sécurité et effets indésirables
A 90-day oral toxicity study in mice, rats, and rabbits using hydroethanolic extract of leaves showed no alterations in body weight gain, relative weight of liver, kidney, and spleen, or histopathological changes [PMID:29565700].
Synthèse des preuves
Evidence ranges from high-level clinical trials for respiratory infections (B) to preclinical in vitro and in vivo studies (D) demonstrating anticancer, antimalarial, and anti-adipogenic activities.
Sources PubMed
1.PMID: 29766690 (2018) — Garden nasturtium (Tropaeolum majus L.) - a source of mineral elements and bioactive compounds. · Roczniki Panstwowego Zakladu Higieny
2.PMID: 27161402 (2016) — Nasturtium (Indian cress, Tropaeolum majus nanum) dually blocks the COX and LOX pathway in primary human immune cells. · Phytomedicine : international journal of phytotherapy and phytopharmacology
3.PMID: 35336212 (2022) — Unraveling the Tropaeolum majus L. (Nasturtium) Root-Associated Bacterial Community in Search of Potential Biofertilizers. · Microorganisms
4.PMID: 38792178 (2024) — Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate. · Molecules (Basel, Switzerland)
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— A combination of Tropaeolum majus herb and Armoracia rusticana root for the treatment of acute bronchitis.
· Phytomedicine : international journal of phytotherapy and phytopharmacology
6.PMID: 36293253 (2022) — Tropaeolum majus R2R3 MYB Transcription Factor TmPAP2 Functions as a Positive Regulator of Anthocyanin Biosynthesis. · International journal of molecular sciences
7.PMID: 35834717 (2023) — Tropaeolum majus L. and low dose gamma radiation suppress liver carcinoma development via EGFR-HER2 signaling pathway. · Natural product research
8.PMID: 37599682 (2023) — A monocentric, randomized, double-blind, controlled crossover trial of nasturtium (Tropaeolum majus) on the lipid regulator prostaglandin E2. · Frontiers in nutrition
9.PMID: 38005794 (2023) — Significant Benefits of Environmentally Friendly Hydrosols from Tropaeolum majus L. Seeds with Multiple Biological Activities. · Plants (Basel, Switzerland)
10.PMID: 35465202 (2022) — Spermine reduces the harmful effects of salt stress in Tropaeolum majus. · Physiology and molecular biology of plants : an international journal of functional plant biology
11.PMID: 37057243 (2023) — Effect of Nasturtium Extract on Oral Cancer. · Advanced biomedical research
12.PMID: 28659749 (2017) — Anti-adipogenic effects of Tropaeolum majus (nasturtium) ethanol extract on 3T3-L1 cells. · Food & nutrition research
13.PMID: 36816870 (2022) — Chemical Composition and Biological Activity of Essential Oil and Extract from the Seeds of Tropaeolum majus L. var. altum. · Food technology and biotechnology
14.PMID: 29565700 (2018) — 90-Day Oral Toxicity Assessment of Tropaeolum majus L. in Rodents and Lagomorphs. · Journal of medicinal food
15.PMID: 26610401 (2016) — Bioavailability and metabolism of benzyl glucosinolate in humans consuming Indian cress (Tropaeolum majus L.). · Molecular nutrition & food research
16.PMID: 36615228 (2022) — Centranthus ruber (L.) DC. and Tropaeolum majus L.: Phytochemical Profile, In Vitro Anti-Denaturation Effects and Lipase Inhibitory Activity of Two Ornamental Plants Traditionally Used as Herbal Remedies. · Molecules (Basel, Switzerland)
17.PMID: 38843802 (2024) — Structural Characterization, and Antioxidative and Anti-inflammatory Activities of Phylloxanthobilins in Tropaeolum majus, a Plant with Relevance in Phytomedicine. · Planta medica
18.PMID: 33862976 (2000) — Differences in glucosinolate patterns and arbuscular mycorrhizal status of glucosinolate-containing plant species. · The New phytologist
19.PMID: 32789672 (2021) — [Uncomplicated urinary tract infections : Use of mustard oils]. · Der Urologe. Ausg. A