How does White Peony work to relieve muscle spasms and cramps?

White Peony contains paeoniflorin, its primary active compound, which acts as an antispasmodic by relaxing smooth muscle tissue. Research suggests it modulates GABA receptors and inhibits involuntary muscle contractions, making it effective for abdominal and uterine cramping. In Traditional Chinese Medicine, it nourishes liver blood and softens tension to relieve spasms. Evidence Level: C.

Does White Peony interact with any medications?

White Peony may interact with anticoagulant and antiplatelet medications due to potential effects on blood clotting pathways. It may also enhance the effects of sedatives and drugs that act on GABA receptors, including benzodiazepines and barbiturates. Those taking blood thinners, antiplatelet drugs, or central nervous system depressants should consult a healthcare provider before use. Evidence Level: C.

What is the recommended dosage for White Peony root?

The typical adult dosage for White Peony is 6-15 grams of dried root prepared as a decoction, or approximately 500mg of standardized extract taken twice daily. In Traditional Chinese Medicine, it is frequently combined with other herbs in formulas, and dosages may vary based on the specific condition. Follow product label instructions or consult a qualified practitioner for personalized dosing.

Is White Peony safe to take during pregnancy?

White Peony is considered unsafe during pregnancy and should be avoided. Traditional use indicates it may stimulate uterine contractions and influence hormone levels, posing potential risks to pregnancy. Women who are pregnant, attempting to conceive, or breastfeeding should not use White Peony without explicit guidance from a qualified healthcare provider. Evidence Level: Traditional.

Can White Peony help regulate irregular menstrual cycles?

White Peony is one of the most widely used herbs in Traditional Chinese Medicine for menstrual regulation. It is traditionally employed to address irregular periods, particularly those associated with blood deficiency patterns, and may help normalize cycle timing while reducing associated cramping. Clinical evidence supporting this use is limited (Level C), but it remains a foundational herb in gynecological formulas.

What are the side effects of taking White Peony?

White Peony is generally well-tolerated at recommended doses. The most commonly reported side effect is mild gastrointestinal discomfort, including nausea or stomach upset. According to Traditional Chinese Medicine principles, it should be avoided in individuals with cold patterns without concurrent blood deficiency. Discontinue use if adverse reactions occur and consult a healthcare provider.

Pivoine blanche (Paeonia lactiflora)

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Paeonia lactiflora (White Peony) is a traditional Chinese medicinal herb used for its anti-inflammatory, analgesic, and neuroprotective properties [PMID:39471979, PMID:39053710].

Contexte

Paeonia lactiflora Pall., also known as Shaoyao or Paeoniae Radix Alba (baishao), is a common herb cultivated globally, particularly in China, Japan, and South Korea [PMID:39053710, PMID:32237400]. It is characterized by its roots, which are processed into medicinal forms [PMID:32237400, PMID:25151277].

Usages traditionnels

It has been used for over a thousand years in traditional Chinese medicine to de-stress the liver, relieve depression, treat gynecological diseases, and manage pain and infections [PMID:37295570, PMID:39053710]. It is also used to treat fever, rheumatoid arthritis, systemic lupus erythematosus, and hepatitis [PMID:36868693].

Composés actifs

Key bioactive constituents include monoterpene glycosides (such as paeoniflorin and albiflorin), polyphenols, tannins, phenolic acids, and paeonols [PMID:33558884, PMID:30144752]. Other identified components include polysaccharides, polydeoxyribonucleotide (PDRN), and triterpenoids [PMID:37295570, PMID:41516097, PMID:38685513].

Mécanisme d'action

Paeonia lactiflora and its components act through several pathways: inhibiting the NLRP3/ASC/Caspase-1 signaling pathway to alleviate depression [PMID:37295570], regulating autophagic dysfunction via AKT signaling for neuroprotection [PMID:41452493], and exerting antinociceptive, anti-inflammatory, and antioxidant activities [PMID:39471979]. Paeoniflorin specifically demonstrates immunomodulatory and anti-inflammatory effects [PMID:32682112, PMID:31610201].

Preuves cliniques

Preuve AIrritable Bowel Syndrome (IBS)

Formulas using Atractylodes macrocephala and Paeonia lactiflora as core pairs are effective for global IBS symptom relief [PMID:38186470]

Preuve BSkin Aging

Low-molecular-weight Paeonia lactiflora-derived PDRN enhanced skin cell proliferation, migration, and epidermal barrier formation [PMID:41516097]

Preuve DDepression

Paeonia lactiflora polysaccharide (PLP) alleviated depressive behavior in CUMS mice models [PMID:37295570]

Preuve DParkinson's Disease

Water extracts and PLE showed neuroprotective effects by regulating gut microbiota (Dubosiella) or improving autophagic flux in mouse models [PMID:40374370, PMID:41452493]

Sécurité et effets indésirables

A genotoxicity assessment indicated that hot-water extracts (PL-W) were not toxic to S. typhimurium or E. coli, but powder extracts (PL-P) produced a mutagenic response in TA100 (absence of S9 mix) and increased chromosomal aberrations in a concentration-dependent manner [PMID:36868693].

Synthèse des preuves

Evidence ranges from high-level systematic reviews for IBS (Level A) to preclinical animal and in vitro studies for neuroprotection and depression (Level D), and clinical assays for skin health (Level B).

Sources PubMed

1.PMID: 37295570 (2023) — Paeonia lactiflora Pall. Polysaccharide alleviates depression in CUMS mice by inhibiting the NLRP3/ASC/Caspase-1 signaling pathway and affecting the composition of their intestinal flora. · Journal of ethnopharmacology
2.PMID: 39227108 (2024) — Composite microneedles loaded with Astragalus membranaceus polysaccharide nanoparticles promote wound healing by curbing the ROS/NF-κB pathway to regulate macrophage polarization. · Carbohydrate polymers
3.PMID: 39471979 (2024) — Pharmacological Effects of Paeonia lactiflora Focusing on Painful Diabetic Neuropathy. · Planta medica
4.PMID: 41516097 (2025) — Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora. · International journal of molecular sciences
5.PMID: 36037599

Pivoine blanche

Sources et citations