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Scrophularia ningpoensis
TCM root used to clear heat, nourish yin, and detoxify, important in treating febrile disease with yin injury and throat conditions.
Xuan Shen (Scrophularia ningpoensis) is a traditional Chinese medicinal root used to clear heat, nourish yin, and detoxify, particularly in febrile diseases with yin injury and throat conditions. Its key active compounds include iridoid glycosides such as harpagoside and harpagide, as well as phenylethanoids, which contribute to its anti-inflammatory, antihypertensive, cardioprotective, and antibacterial properties.
The iridoid glycosides, especially harpagoside, inhibit pro-inflammatory mediators like COX-2 and NF-κB, reducing inflammation. Harpagoside also modulates the renin-angiotensin system and enhances nitric oxide production, leading to vasodilation and antihypertensive effects. Cardioprotective actions involve antioxidant activity and suppression of oxidative stress pathways. Antibacterial effects are attributed to aucubin and phenylethanoids disrupting bacterial cell membranes.
TCM root used to clear heat, nourish yin, and detoxify, important in treating febrile disease with yin injury and throat conditions.
Xuan Shen (Scrophularia ningpoensis) is a traditional Chinese medicinal root used to clear heat, nourish yin, and detoxify, particularly in febrile diseases with yin injury and throat conditions. Its key active compounds include iridoid glycosides such as harpagoside and harpagide, as well as phenylethanoids, which contribute to its anti-inflammatory, antihypertensive, cardioprotective, and antibacterial properties.
The iridoid glycosides, especially harpagoside, inhibit pro-inflammatory mediators like COX-2 and NF-κB, reducing inflammation. Harpagoside also modulates the renin-angiotensin system and enhances nitric oxide production, leading to vasodilation and antihypertensive effects. Cardioprotective actions involve antioxidant activity and suppression of oxidative stress pathways. Antibacterial effects are attributed to aucubin and phenylethanoids disrupting bacterial cell membranes.