Zatoun (Olea europaea (leaf)): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does olive leaf extract lower blood pressure?

Olive leaf (Olea europaea) works primarily through oleuropein, which acts as a natural ACE inhibitor, helping relax blood vessels and improve blood flow. The compound also reduces oxidative stress on blood vessel walls through its antioxidant properties. Hydroxytyrosol and luteolin contribute additional vasodilatory effects. Evidence Level C supports these mechanisms for hypertension management, though more clinical trials are needed to fully establish the pathway.

Can I take olive leaf with blood pressure medication?

Olive leaf may interact with antihypertensive medications, potentially causing additive effects and leading to hypotension (dangerously low blood pressure). If you take ACE inhibitors, beta-blockers, or calcium channel blockers, consult your healthcare provider before using olive leaf supplements. Close monitoring of blood pressure is recommended if combining these treatments. The interaction risk is supported by Evidence Level C data.

What is the recommended dosage for olive leaf extract?

For adults, the typical dosage is olive leaf tea consumed 2-3 cups daily, or 250-500mg of oleuropein-standardized extract per day. Standardized extracts ensure consistent oleuropein content, the primary active compound. Dosage may vary based on the condition being addressed. Start with lower doses to assess tolerance, and consult a qualified healthcare practitioner for personalized recommendations.

Is olive leaf extract safe during pregnancy?

Olive leaf extract is not recommended during pregnancy, particularly at therapeutic doses. Available evidence (Level C) and traditional use suggest potential risks, including hypoglycemic effects that could affect fetal development. Pregnant women should avoid medicinal doses of olive leaf, though culinary amounts of olives and olive oil are generally considered safe. Always consult your healthcare provider before using any herbal supplement during pregnancy.

What is olive leaf good for?

Olive leaf has been used traditionally in Mediterranean, North African, and Middle Eastern medicine for managing hypertension, diabetes, and infections. The active compounds oleuropein and hydroxytyrosol provide antioxidant, anti-inflammatory, and antimicrobial properties. Evidence Level C supports these traditional uses, with preliminary research suggesting benefits for blood sugar regulation, cardiovascular health, and immune support.

What are the side effects of olive leaf extract?

Common side effects include mild gastrointestinal discomfort, such as nausea or stomach upset, particularly when taken on an empty stomach. More significant effects can include hypoglycemia (low blood sugar) and hypotension (low blood pressure), especially in individuals with diabetes or those taking blood pressure medications. These effects are generally dose-dependent. Discontinue use if symptoms persist and consult a healthcare provider.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Olea europaea (olive) leaf is a source of bioactive polyphenols with antioxidant, anti-inflammatory, and antimicrobial properties [PMID:31901903, 33334001].

Contexte

Olea europaea leaves are a byproduct of the olive oil production chain and contain a higher concentration of antioxidant components than the fruit [PMID:28871681, 39631768].

Usages traditionnels

Olive tree leaves have been widely used in traditional herbal medicine, particularly in Mediterranean countries, to prevent and treat various diseases [PMID:31901903].

Composés actifs

The primary bioactive compounds are phenolic compounds, specifically oleuropein, hydroxytyrosol, and flavonoids [PMID:31901903, 36901783, 39631768].

Mécanisme d'action

Mechanisms include the modulation of NF-κB and Nrf2 to decrease neuroinflammation and oxidative stress [PMID:36901783], suppression of pro-inflammatory mediators (TNF-α, IL-6, IL-1β, NO, PGE2) in macrophages [PMID:33260769], and post-transcriptional suppression of the epithelial-mesenchymal transition (EMT) in gastric cancer cells [PMID:38467548].

Preuves cliniques

Preuve BPostmenopausal symptoms

Supplementation with 250 mg/day of olive leaf extract (OLE) for 12 weeks significantly improved overall MENQoL scores and bone mineral density in the right arm [PMID:39599665]

Preuve BStage-1 Hypertension

Olive leaf extract (500 mg twice daily) was evaluated for anti-hypertensive effects in comparison with Captopril [PMID:21036583]

Preuve BType 2 Diabetes Mellitus

A pilot randomized controlled trial found no statistically significant time-group interaction for HbA1c change after 24 weeks of OLE capsules [PMID:39818111]

Preuve BSmall Intestinal Bacterial Overgrowth (SIBO)

Olive leaf tea (1.7g leaf powder/250mL water twice daily) was studied for effects on gastrointestinal symptoms and body composition [PMID:40917089]

Sécurité et effets indésirables

Toxicity studies suggest that olive leaf is generally safe, even at high doses [PMID:31901903].

Synthèse des preuves

Evidence ranges from preclinical animal/in vitro models showing strong antioxidant and anti-inflammatory activity to pilot clinical trials with mixed results regarding glycemic control and positive results for postmenopausal quality of life.

Sources PubMed

1.PMID: 38933415 (2024) — Olea europaea leaf exosome-like nanovesicles encapsulated in a hyaluronic acid / tannic acid hydrogel dressing with dual "defense-repair" effects for treating skin photoaging. · Materials today. Bio
2.PMID: 31901903 (2020) — Olive Leaf (Olea europaea L. folium): Potential Effects on Glycemia and Lipidemia. · Annals of nutrition & metabolism
3.PMID: 25726243 (2014) — Polyphenols benefits of olive leaf (Olea europaea L) to human health. · Nutricion hospitalaria
4.PMID: 35614890 (2022) — Olea europaea L. (olive) leaf extract ameliorates learning and memory deficits in streptozotocin-induced diabetic rats. · Avicenna journal of phytomedicine
5.PMID: 39818111 (2025) — Efficacy and safety of olive leaf extract (Olea europaea L.) for glycaemic control in adults with type 2 diabetes mellitus (ESOLED): A pilot randomised controlled trial.

Zatoun

Sources et citations

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