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Zedoary contains bioactive compounds including curdione, curcumenol, furanodiene, and zedoarone, which contribute to its therapeutic effects. These compounds demonstrate anti-inflammatory, antioxidant, and potential anticancer properties in laboratory studies. In traditional medicine, zedoary is believed to promote blood circulation, resolve blood stasis, and stimulate digestive function. The volatile oils in the rhizome appear to stimulate bile secretion and gastrointestinal motility. Evidence level: C (preliminary research with limited clinical trials).
Can I take zedoary with blood thinners?
Zedoary should not be combined with anticoagulant or antiplatelet medications. As a close relative of turmeric, zedoary may affect blood clotting and increase bleeding risk when taken with drugs like warfarin, aspirin, or clopidogrel. This herb is traditionally used to 'invigorate blood' and resolve stasis, which translates to potential anticoagulant effects. Patients on anticoagulant therapy should avoid zedoary entirely. Always consult your healthcare provider before combining herbs with prescription medications.
What is the recommended dosage of zedoary?
The typical adult dosage of zedoary is 3-9 grams of dried rhizome prepared as a decoction, or approximately 500mg of standardized extract daily. Traditional practitioners often adjust doses based on individual constitution and the condition being addressed. Standardized extracts should be taken according to manufacturer instructions. Consult a qualified herbalist or healthcare practitioner for personalized dosing guidance, as higher doses may increase the risk of gastrointestinal side effects.
Is zedoary safe during pregnancy?
Zedoary is contraindicated during pregnancy and should be strictly avoided. This herb has a long-standing reputation in both Ayurvedic and Traditional Chinese Medicine for promoting blood circulation and breaking up stagnation. These properties may stimulate uterine contractions and potentially lead to miscarriage or pregnancy complications. Women who are pregnant, trying to conceive, or breastfeeding should not use zedoary in any form. Additionally, zedoary is not recommended during heavy menstruation due to its blood-moving properties.
What is zedoary used for in herbal medicine?
Zedoary is traditionally used to address blood stasis, abdominal masses, digestive stagnation, and various types of pain. In Ayurveda and Traditional Chinese Medicine, it is valued for its ability to 'break up masses' and improve digestive function. Preliminary research (Evidence level C) has investigated zedoary's potential anticancer properties, particularly compounds like curcumenol and furanodiene. However, clinical evidence remains limited. This herb should be used under professional guidance rather than for self-treatment of serious conditions.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Zedoary (Curcuma zedoaria) is a perennial herb used in traditional medicine for treating cancer, liver disorders, and inflammatory conditions [PMID:19126292, PMID:30947655].
Contexte
Curcuma zedoaria, also known as white turmeric, is a perennial herb found in tropical regions including India, Japan, and Thailand [PMID:19126292]. In Traditional Chinese Medicine (TCM), it is referred to as Curcumae Rhizoma or Ezhu [PMID:36405057].
Usages traditionnels
Traditionally used in Ayurveda and folk medicine for diarrhea, cancer, flatulence, and dyspepsia [PMID:19126292]. In Asian countries including Korea, China, and Japan, it has been used to treat headache, fever, and hypertension-related symptoms [PMID:34093973]. TCM uses it to treat distending pain of the chest and belly, arthralgia, and conditions characterized by Qi stagnation and blood stasis [PMID:34592340, PMID:40615101].
Composés actifs
Major chemical constituents include Zedoary Turmeric Oil (ZTO) [PMID:40615101] and various sesquiterpenes such as curcumol, zedoarondiol, curcumenol, curzerenone, curdione, germacrone, and β-elemene [PMID:36405057]. Other identified compounds include curcumin [PMID:40615101], furanodiene, furanodienone [PMID:16901812], and the diphenylheptanoid zedoaroxane A [PMID:34787385].
Mécanisme d'action
Zedoary components act via multiple targets; for example, β-elemene promotes ferroptosis by inhibiting the OTUB1-GPX4 interaction in gastric cancer [PMID:39484165] and inhibits endometriosis via MAPK and STAT3 signaling pathways [PMID:39800242]. Curcumol modulates the Fas/RIPK1-mediated PANoptosis pathway to alleviate endometriosis [PMID:41341035]. ZTO may exert anti-hepatocellular carcinoma effects via EGFR/p53/Bcl-2 mediation [PMID:40615101].
Preuves cliniques
Preuve DAtherosclerosis
Dietary intake of C. zedoaria extract (100 mg/kg/day) in ApoE-deficient mice showed a 41.6% reduction of atherosclerosis and reduced serum triglycerides [PMID:34093973]
Preuve DCisplatin-induced kidney damage
Combined extracts of Curcuma longa and Curcuma zedoaria (100-400 mg/kg) in rats decreased TNF-α, KIM-1, and caspase-3 expression levels [PMID:4009217도, PMID:41509124]
Preuve BHypercholesterolemia
Zedoary herbal tea was evaluated for antihypercholesterolemic and antilipidemic perspectives [PMID:26920896]
Preuve DGastric Cancer
β-elemene reverses radioresistance and inhibits cell growth when combined with radiotherapy in gastric cancer cells [PMID:39484165]
Preuve DLiver Cancer
Zedoary turmeric oil and its components (e.g., curcumol) demonstrate anti-hepatoma effects through multi-target channels [PMID:36405057, PMID:40615101]
Sécurité et effets indésirables
Zedoary turmeric oil injection (ZTOI) has been associated with adverse drug reactions, specifically the induction of dyspnea, which is linked to the binding of β-elemene to hemoglobin and upregulation of HIF-1α [PMID:38042387, PMID:35318816]. A topical water-balm formulation containing 15% essential oil was well tolerated with no skin irritation in volunteers [PMID:42100665].
Synthèse des preuves
The evidence consists primarily of in vitro studies, animal models (mice/rats), and a few reviews, indicating strong pharmacological potential but limited high-level human clinical trial data.
Sources PubMed
1.PMID: 34592340 (2022) — Curcumin inhibits the invasion and metastasis of triple negative breast cancer via Hedgehog/Gli1 signaling pathway. · Journal of ethnopharmacology
2.PMID: 40615101 (2025) — Integrated network pharmacology and experimental validation reveal EGFR/p53/Bcl-2-mediated anti-hepatocellular carcinoma effects of Zedoary Turmeric Oil. · Journal of ethnopharmacology
3.PMID: 36405057 (2022) — Analysis on internal mechanism of zedoary turmeric in treatment of liver cancer based on pharmacodynamic substances and pharmacodynamic groups. · Chinese herbal medicines
4.PMID: 40092179 (2025) — Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats. · Open veterinary journal
5.PMID: 36158488 (2022) — Network pharmacology and molecular docking reveal zedoary turmeric-trisomes in Inflammatory bowel disease with intestinal fibrosis.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 34093973 (2021) — Extract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient mice. · Nutrition research and practice
7.PMID: 39484165 (2024) — β-Elemene promotes ferroptosis and reverses radioresistance in gastric cancer by inhibiting the OTUB1-GPX4 interaction. · Frontiers in pharmacology
8.PMID: 19126292 (2009) — Curcuma zedoaria Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties. · The Journal of pharmacy and pharmacology
9.PMID: 42100665 (2026) — Repellent efficacy of water-balm formulation against Aedes aegypti based on zedoary, Curcuma zedoaria. · Current research in parasitology & vector-borne diseases
10.PMID: 36703758 (2022) — Curcumae Rhizoma: A botanical drug against infectious diseases. · Frontiers in pharmacology
11.PMID: 40799052 (2025) — Dietary Supplementation With White and Common Turmeric Improves Resistance to Argulus siamensis in Labeo rohita. · Parasite immunology
12.PMID: 38338400 (2024) — The Extraction, Determination, and Bioactivity of Curcumenol: A Comprehensive Review. · Molecules (Basel, Switzerland)
13.PMID: 38042387 (2024) — β-Elemene in zedoary turmeric oil injection induces dyspnea by binding to hemoglobin and upregulating HIF-1α. · Journal of ethnopharmacology
14.PMID: 16901812 (2006) — Anti-inflammatory sesquiterpenes from Curcuma zedoaria. · Natural product research
15.PMID: 22083983 (2011) — Applications of nanoparticles in herbal medicine: zedoary turmeric oil and its active compound β-elemene. · The American journal of Chinese medicine
16.PMID: 26920896 (2016) — Phytopreventive antihypercholesterolmic and antilipidemic perspectives of zedoary (Curcuma Zedoaria Roscoe.) herbal tea. · Lipids in health and disease
17.PMID: 34787385 (2022) — A new diphenylheptanoid from the rhizomes of Curcuma zedoaria. · Zeitschrift fur Naturforschung. C, Journal of biosciences
18.PMID: 30534696 (2019) — Combination of curcuma zedoary and kelp inhibits growth and metastasis of liver cancer in vivo and in vitro via reducing endogenous H2S levels. · Food & function
19.PMID: 41341035 (2025) — Curcumol alleviates endometriosis via correcting the aberrant activation of Fas/RIPK1-mediated PANoptosis. · Frontiers in pharmacology
20.PMID: 30947655 (2019) — Ethnobotany, Phytochemistry and Traditional Uses of Curcuma spp. and Pharmacological Profile of Two Important Species (C. longa and C. zedoaria): A Review. · Current pharmaceutical design
21.PMID: 30884305 (2019) — Sesquiterpenes from Curcuma zedoaria rhizomes and their cytotoxicity against human gastric cancer AGS cells. · Bioorganic chemistry
22.PMID: 39800242 (2025) — β-elemene, a sesquiterpene constituent from Curcuma phaeocaulis inhibits the development of endometriosis by inducing ferroptosis via the MAPK and STAT3 signaling pathways. · Journal of ethnopharmacology
23.PMID: 15848035 (2005) — Antimicrobial activity of Curcuma zedoaria and Curcuma malabarica tubers. · Journal of ethnopharmacology
24.PMID: 41509124 (2025) — The extract of zedoary-turmeric protects rats' kidneys from damage caused by cisplatin. · Journal of advanced veterinary and animal research
25.PMID: 35318816 (2022) — Network pharmacology-based dissection of the underlying mechanisms of dyspnoea induced by zedoary turmeric oil. · Basic & clinical pharmacology & toxicology
26.PMID: 30200410 (2018) — Chemical Composition and Biological Activities of Essential Oils of Curcuma Species. · Nutrients
27.PMID: 31151312 (2019) — Identification of a Quality Marker of Vinegar-Processed Curcuma Zedoaria on Oxidative Liver Injury. · Molecules (Basel, Switzerland)