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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Amorphophallus konjac is a perennial herb from the Araceae family, primarily valued for its bioactive polysaccharide, konjac glucomannan (KGM) [PMID:35242290, PMID:40117876].
Background
Amorphophallus konjac is a perennial tuberous plant native to Southeast Asia [PMID:40061034, PMID:39478464]. It is an economically important crop used in health products, biomaterials, and as a food source [PMID:38114626, PMID:20079822].
Traditional uses
In traditional Chinese medicine, konjac gel has been used for detoxification, tumor-suppression, blood stasis alleviation, and phlegm liquefaction; it has also been used for over 2000 years to treat asthma, cough, hernia, breast pain, burns, and haematological and skin disorders [PMID:20079822]. The genus is also used in Ayurveda and Unani medical practices [PMID:38068582].
Active compounds
The primary bioactive component is konjac glucomannan (KGM), a soluble, highly viscous dietary fiber polysaccharide derived from the corm/root [PMID:30000957, PMID:29606469, PMID:40117876]. The plant also contains polyphenolic compounds, alkaloids, steroids, fats, fixed oils, tannins, proteins, and carbohydrates [PMID:38068582].
Mechanism of action
KGM may promote weight loss by promoting satiety and fecal energy loss [PMID:16320857]. It can form a defensive covering on the surface of the intestine [PMID:30586587] and may exert prebiotic effects through colonic fermentation into short-chain fatty acids (SCFAs) [PMID:26676961, PMID:29971989]. In animal models, KGM has been shown to promote lymphocyte proliferation and increase cytokine levels (TNF-α, IgG, IL-2) [PMID:33598158].
Clinical evidence
Evidence CObesity/Weight Management
Doses of 2-4 g per day resulted in significant weight loss in overweight and obese individuals [PMID:16320857].
Evidence CMetabolic Health
KGM has been shown to improve lipid and lipoprotein parameters, glycemic status, and reduce cholesterol, triglycerides, and blood pressure [PMID:16320857, PMID:30586587, PMID:38823930].
Evidence CDiabetes
KGM is used to treat diabetes and stabilize blood glucose [PMID:30000957, PMID:40061034].
Evidence CConstipation
KGM is used to treat constipation [PMID:30000957].
Safety & adverse effects
KGM is reported to be well-tolerated at doses of 2-4 g per day [PMID:16320857]. It is described as having low toxicity and high biocompatibility [PMID:24607175, PMID:38320637].
Pregnancy & lactation
No data exist on the safety and efficacy of glucomannan in nursing mothers or infants; however, because it is not absorbable, it is unlikely to reach breastmilk or affect the nursing infant [PMID:30000957].
Evidence summary
The evidence is primarily based on reviews and animal studies (Level C and D), with some preliminary clinical evidence for weight loss and metabolic improvement.
PubMed sources
1.PMID: 30000957 (2006) — Konjac glucomannan, a promising polysaccharide of Amorphophallus konjac K. Koch in health care. · International journal of biological macromolecules
2.PMID: 26676961 (2016) — Beneficial health characteristics of native and hydrolysed konjac (Amorphophallus konjac) glucomannan. · Journal of the science of food and agriculture
3.PMID: 38114626 (2023) — Characteristics of Amorphophallus konjac as indicated by its genome. · Scientific reports
4.PMID: 32603265 (2020) — Taro koji of Amorphophallus konjac enabling hydrolysis of konjac polysaccharides to various biotechnological interest. · Bioscience, biotechnology, and biochemistry
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— A chromosome-level genome assembly of Amorphophallus konjac provides insights into konjac glucomannan biosynthesis.
· Computational and structural biotechnology journal
6.PMID: 29606469 (2018) — Modifications of konjac glucomannan for diverse applications. · Food chemistry
7.PMID: 16320857 (2005) — Glucomannan and obesity: a critical review. · Alternative therapies in health and medicine
8.PMID: 33598158 (2021) — Konjac Glucomannan from Amorphophallus konjac enhances immunocompetence of the cyclophosphamide-induced immunosuppressed mice. · Food science & nutrition
9.PMID: 40061034 (2025) — Amorphophallus konjac: traditional uses, bioactive potential, and emerging health applications. · Frontiers in plant science
10.PMID: 35808596 (2022) — Review on Modification of Glucomannan as an Excipient in Solid Dosage Forms. · Polymers
11.PMID: 29971989 (2018) — Depolymerized konjac glucomannan: preparation and application in health care. · Journal of Zhejiang University. Science. B
12.PMID: 37473898 (2023) — Konjac glucomannan-based hydrogels with health-promoting effects for potential edible electronics applications: A mini-review. · International journal of biological macromolecules
13.PMID: 24607175 (2014) — Konjac glucomannan, a promising polysaccharide for OCDDS. · Carbohydrate polymers
14.PMID: 38068582 (2023) — Genus Amorphophallus: A Comprehensive Overview on Phytochemistry, Ethnomedicinal Uses, and Pharmacological Activities. · Plants (Basel, Switzerland)
15.PMID: 38320637 (2024) — Advances in the construction and application of konjac glucomannan-based delivery systems. · International journal of biological macromolecules
16.PMID: 30586587 (2019) — Health-promoting effects of konjac glucomannan and its practical applications: A critical review. · International journal of biological macromolecules
18.PMID: 40117876 (2025) — Extraction, structure, activity and application of konjac glucomannan. · Ultrasonics sonochemistry
19.PMID: 38823930 (2024) — Konjac glucomannan: A comprehensive review of its extraction, health benefits, and pharmaceutical applications. · Carbohydrate polymers
20.PMID: 39478464 (2024) — Genome-wide analysis of the Amorphophallus konjac AkCSLA gene family and its functional characterization in drought tolerance of transgenic arabidopsis. · BMC plant biology
21.PMID: 20079822 (2010) — Traditional uses and potential health benefits of Amorphophallus konjac K. Koch ex N.E.Br. · Journal of ethnopharmacology