This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Arrabidaea chica (also known as Fridericia chica) is a medicinal vine native to the Amazon region used traditionally for inflammation, wound healing, and various systemic disorders [PMID:36139047, PMID:40474821].
Background
Arrabidaea chica (synonym Fridericia chica), commonly known as crajiru or pariri, is a plant species of the Bignoniaceae family widely distributed in Brazil and tropical America [PMID:31732026, PMID:40474821].
Traditional uses
Used in folk medicine as a tea or preparation for intestinal colic, diarrhea, anemia, inflammation, skin diseases, leukemia, blood disorders such as hemorrhage, and viral diseases including measles, chickenpox, and herpes [PMID:36139047, PMID:40474821, PMID:32756445, PMID:24009700].
Active compounds
The plant contains phenolic compounds, including flavonoids such as scutellarein (the main phenolic compound), luteolin, apigenin, isoscutellarein, 6-hydroxyluteolin, and hispidulin [PMID:31732026, PMID:34354593, PMID:24009700]. Other identified compounds include 3-desoxyanthocyanidins (carajurin, carajurone), carotenoids (lutein, $\beta$-carotene, $\alpha$-carotene), ascorbic acid, and various quinones [PMID:11324913, PMID:31732026, PMID:21772750].
Mechanism of action
The herb demonstrates antioxidant activity by scavenging reactive oxygen species (ROS) and nitrogen species (RNS) [PMID:36290636, PMID:29156345]. It promotes wound healing by favoring fibroblast proliferation and collagen production [PMID:36139047, PMID:18573628]. Specific compounds like carajurin inhibit the transcription factor NF-kappaB [PMID:11324913], and certain fractions preferentially inhibit COX-2 [PMID:33881683].
Clinical evidence
Evidence BOral Mucositis
A mucoadhesive gel containing 2.5% A. chica extract was evaluated for wound healing potential in oncohematological patients undergoing bone marrow transplantation [PMID:41394293].
Evidence DWound Healing (Animal/In Vitro)
Extracts stimulated fibroblast growth and reduced wound area in rat models [PMID:18573628, PMID:36139047].
Evidence DBreast Cancer (Animal/In Vitro)
Oral administration of extract significantly reduced breast tumor incidence in DMBA-induced rat models [PMID:31826147] and modulated estrogen and androgen receptors in luminal breast cancer cells [PMID:35057779].
Evidence DLeishmaniasis (In Vitro)
Crude extracts and isolated anthocyanidins (carajurin) showed activity against promastigote and amastigote forms of Leishmania amazonensis [PMID:34323692, PMID:34354593].
Evidence DHepatotoxicity (Animal)
Hydroethanolic extract reduced GPT, GOT, and bilirubin levels in CCl4-induced liver injury rats [PMID:21772750].
Evidence D
Safety & adverse effects
Acute and subchronic toxicity evaluations in mice and rats using hydroethanolic extract did not indicate significant toxicity at doses up to the tested levels [PMID:24070833].
Evidence summary
The evidence is primarily based on in vitro studies and animal models (Level D), with emerging randomized clinical trial data (Level B) specifically for the treatment of oral mucositis via mucoadhesive gel.
PubMed sources
1.PMID: 36139047 (2022) — Therapeutic Potential of Leaves from Fridericia chica (Bonpl.) L. G. Lohmann: Botanical Aspects, Phytochemical and Biological, Anti-Inflammatory, Antioxidant and Healing Action. · Biomolecules
2.PMID: 40474821 (2025) — Fridericia chica (Bonpl.) L.G. Lohmann: An Overview of Medicinal Plant Studies. · Journal of medicinal food
3.PMID: 32848479 (2020) — Standardized Arrabidaea chica Extract Shows Cytoprotective Effects in Zoledronic Acid-Treated Fibroblasts and Osteoblasts. · Clinical, cosmetic and investigational dentistry
4.PMID: 38931948 (2024) — Immunomodulatory and Anticancer Effects of Fridericia chica Extract-Loaded Nanocapsules in Myeloid Leukemia. · Pharmaceutics
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Standardized extract showed cytoprotective effects on fibroblasts and osteoblasts exposed to zoledronic acid [PMID:32848479].
(2019)
— Profile of phenolic compounds and carotenoids of Arrabidaea chica leaves and the in vitro singlet oxygen quenching capacity of their hydrophilic extract.
· Food research international (Ottawa, Ont.)
6.PMID: 11324913 (2001) — 3-Desoxyanthocyanidins from Arrabidaea chica. · Phytochemistry
7.PMID: 25683298 (2015) — Evaluation of anti-inflammatory, antiangiogenic and antiproliferative activities of Arrabidaea chica crude extracts. · Journal of ethnopharmacology
8.PMID: 32756445 (2020) — The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes. · Molecules (Basel, Switzerland)
9.PMID: 34354593 (2021) — Antileishmanial Activity of Flavones-Rich Fraction From Arrabidaea chica Verlot (Bignoniaceae). · Frontiers in pharmacology
10.PMID: 21772750 (2011) — Liver protective activity of a hydroethanolic extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri). · Pharmacognosy research
11.PMID: 31826147 (2019) — Effect of Arrabidaea chica extract against chemically induced breast cancer in animal model. · Acta cirurgica brasileira
12.PMID: 35057779 (2022) — Arrabidaea chica chloroform extract modulates estrogen and androgen receptors on luminal breast cancer cells. · BMC complementary medicine and therapies
13.PMID: 18573628 (2008) — Evaluation of wound healing properties of Arrabidaea chica Verlot extract. · Journal of ethnopharmacology
14.PMID: 37623634 (2023) — Antimicrobial and Antioxidant Activities of Endophytic Fungi Associated with Arrabidaea chica (Bignoniaceae). · Journal of fungi (Basel, Switzerland)
15.PMID: 35335440 (2022) — Cost Function Analysis Applied to Different Kinetic Release Models of Arrabidaea chica Verlot Extract from Chitosan/Alginate Membranes. · Polymers
16.PMID: 26089666 (2015) — Chitosan-tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity. · International journal of nanomedicine
17.PMID: 24070833 (2013) — Evaluation of the toxicity and antimicrobial activity of hydroethanolic extract of Arrabidaea chica (Humb. & Bonpl.) B. Verl. · Journal of ethnopharmacology
18.PMID: 23047299 (2013) — Arrabidaea chica extract improves gait recovery and changes collagen content during healing of the Achilles tendon. · Injury
19.PMID: 30341109 (2018) — Arrabidaea chica for oral mucositis in patients with head and neck cancer: a protocol of a randomised clinical trial. · BMJ open
20.PMID: 41394293 (2025) — Healing Oral Mucositis With Arrabidaea chica Verlot Mucoadhesive Gel in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Randomized Controlled Clinical Trial. · BioMed research international
21.PMID: 36290636 (2022) — Scavenging Capacity of Extracts of Arrabidaea chica Leaves from the Amazonia against ROS and RNS of Physiological and Food Relevance. · Antioxidants (Basel, Switzerland)
22.PMID: 33881683 (2021) — Arrabidaea chica Verlot fractions reduce MIA-induced osteoarthritis progression in rat knees. · Inflammopharmacology
23.PMID: 32806286 (2020) — Polyphenol-enriched extract of Arrabidaea chica used as a dentin pretreatment or incorporated into a total-etching adhesive system: Effects on bonding stability and physical characterization. · Materials science & engineering. C, Materials for biological applications
24.PMID: 29156345 (2018) — The extended production of UV-induced reactive oxygen species in L929 fibroblasts is attenuated by posttreatment with Arrabidaea chica through scavenging mechanisms. · Journal of photochemistry and photobiology. B, Biology
25.PMID: 26729470 (2016) — Leishmanicidal, cytotoxicity and wound healing potential of Arrabidaea chica Verlot. · BMC complementary and alternative medicine
26.PMID: 38276023 (2024) — Isolation and Identification of Pigment-Producing Endophytic Fungi from the Amazonian Species Fridericia chica. · Journal of fungi (Basel, Switzerland)
27.PMID: 34323692 (2021) — Carajurin: a anthocyanidin from Arrabidaea chica as a potential biological marker of antileishmanial activity. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
29.PMID: 39412496 (2025) — Friedericia Chica, a Medicinal Plant from the Amazon Region, is Repellent Against Aedes Aegypti: In Vivo and Molecular Docking Evidence. · Chemistry & biodiversity
30.PMID: 24009700 (2013) — Antioxidant capacity of the leaf extract obtained from Arrabidaea chica cultivated in Southern Brazil. · PloS one