PubMed-compiled information sheet
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Compiled from 4 PubMed articles · model: gemma4:31b
Summary
Berberine is a poorly water-soluble alkaloid compound with anti-inflammatory characteristics [PMID:39091899] and the ability to increase glucose consumption in specific cell models [PMID:24361332].
Background
Berberine is an alkaloid compound found in medicinal herbs such as Rhizoma Coptidis [PMID:24361332, PMID:2350424].
Traditional uses
The combination of Radix Scutellariae and Rhizoma Coptidis (scutellaria-coptis herb couple) is known for heat clearing and detoxifying effects [PMID:24361332].
Active compounds
The primary active compound is berberine (often as berberine HCl), which is categorized as a coptis alkaloid [PMID:39091899, PMID:2350424].
Mechanism of action
Berberine reduces levels of pro-inflammatory and inflammatory cytokines, specifically tumour necrosis factor (TNF-α, IFN-γ) and interleukins (IL-23, IL-12) [PMID:39091899]. It also increases glucose consumption in 3T3-L1 adipocytes and HepG2 hepatocytes in a dose-dependent manner [PMID:24361332].
Clinical evidence
Evidence DInflammation
Shows significant anti-inflammatory characteristics by reducing pro-inflammatory cytokines [PMID:39091899]
Evidence DGlucose Uptake
Increased glucose consumption in 3T3-L1 adipocytes and HepG2 hepatocytes in a dose-dependent manner [PMID:24361332]
Evidence summary
The provided evidence is limited to in vitro cell studies and formulation research; no completed clinical trial results were provided.
PubMed sources
- 1.PMID: 39091899 (2024) — Berberine HCl and diacerein loaded dual delivery transferosomes: Formulation and optimization using Box-Behnken design. · ADMET & DMPK
- 2.PMID: 30616613 (2019) — Polyherbal dietary supplementation for prediabetic adults: study protocol for a randomized controlled trial. · Trials
- 3.PMID: 24361332 (2014) — Interaction of baicalin with berberine for glucose uptake in 3T3-L1 adipocytes and HepG2 hepatocytes. · Journal of ethnopharmacology
- 4.PMID: 2350424 (1990) — [Application of equal value derivative spectrophotometry to the determination of coptis alkali in wanshi niuhuang qingxin pills]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica