PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Methanolic, ethanolic, and aqueous extracts exhibit selective cytotoxicity against cancer cells (including prostate, melanoma, lung, and colorectal) while showing minimal impact on healthy cells [PMID:39512529, PMID:39408283, PMID:36430391, PMID:22181840].
Lanostane-type triterpene acids suppressed TPA-induced edema on mouse ears by 49-86% [PMID:12932134].
Water and methanol extracts did not induce significant apoptosis or necrosis of T cells and monocytes, nor did they significantly alter T-cell activation or dendritic cell maturation [PMID:30806295].
Acute and subchronic (14 days) oral administration of crude ethanolic extract, fractions, and stigmasterol did not alter mean arterial pressure, heart rate, or renal blood flow in normotensive male Wistar rats [PMID:28605341].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 28378220 (2017) — Fomitopsis betulina (formerly Piptoporus betulinus): the Iceman's polypore fungus with modern biotechnological potential. · World journal of microbiology & biotechnology
- 2.PMID: 39512529 (2024) — Cytotoxic activity of Fomitopsis betulina against normal and cancer cells - a comprehensive literature review. · Contemporary oncology (Poznan, Poland)
- 3.PMID: 39330376 (2024) — Secondary Metabolites of Fomitopsis betulina: Chemical Structures, Biological Activity and Application Prospects. · Journal of fungi (Basel, Switzerland)
- 4.PMID: 30806295 (2018) — Effects of Birch Polypore Mushroom, Piptoporus betulinus (Agaricomycetes), the "Iceman's Fungus", on Human Immune Cells. · International journal of medicinal mushrooms
- 5.PMID: 24786572