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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Butterfly pea flower (Clitoria ternatea) is a leguminous plant used in traditional medicine and as a natural food colorant, possessing antioxidant, anti-inflammatory, and antimicrobial properties [PMID:33967304, PMID:34975979].
Background
Clitoria ternatea, also known as butterfly pea or blue pea, is a perennial leguminous herb native to tropical Asia [PMID:31191573, PMID:39598271]. It is grown as an ornamental plant and used in culinary applications, such as tea and rice coloring [PMID:34975979, PMID:37273557, PMID:34996311].
Traditional uses
Traditionally used in Ayurvedic and Southeast Asian medicine to treat indigestion, constipation, arthritis, skin diseases, liver and intestinal problems [PMID:33967304, PMID:41130581]. It has also been used as a memory enhancer, nootropic, antistress, anxiolytic, antidepressant, and sedative agent [PMID:18926895].
Active compounds
Key phytochemicals include anthocyanins (specifically polyacylated anthocyanins known as ternatins), kaempferol, quercetin, myricetin glycosides, steroids, triterpenoids, alkaloids, and tannins [PMID:33967304, PMID:34975979, PMID:18926895, PMID:39598271]. The plant also contains cyclotides, which are ultra-stable macrocyclic peptides [PMID:31191573].
Mechanism of action
The flower extracts demonstrate antioxidant activity via the reduction of oxidative stress [PMID:33801631, PMID:34622460]. In hypertensive models, it modulates the Ang II/AT1 R/TGF-β1 cascade and suppresses the renin-angiotensin system [PMID:34622460]. In arthritis models, it is associated with the downregulation of synovial matrix metalloproteases and TNFR1 neutralization [PMID:28826781].
Clinical evidence
Evidence BDandruff
A pretest-posttest control study compared 20% C. ternatea shampoo to 2% ketoconazole shampoo; however, the provided abstract notes that 2% ketoconazole significantly reduced Malassezia spp. DNA expression (full comparative result for C. ternatea not detailed in abstract) [PMID:39280272].
Evidence DHypertension (Animal Model)
CT extract (300 mg/kg/day) reduced blood pressure and attenuated cardiac hypertrophy and vascular dysfunction in hypertensive rats [PMID:33801631, PMID:34622460].
Evidence DCognitive Decline (Animal Model)
Bio-enhanced root extract (CTRF) and clitorienolactones A (CLA) restored cognitive deficits and reversed inhibition of neuroplasticity in chronic cerebral hypoperfusion rat models [PMID:37343678, PMID:38442748].
Anthocyanin-rich extracts lowered plasma glucose, LPS, and TNF-α levels and restored lipid metabolism in high-fat-diet mouse models [PMID:37526116].
Safety & adverse effects
In vitro safety assessments using OECD-validated methods (including MTT cytotoxicity and phototoxicity assays) were conducted to evaluate dermal safety [PMID:41130581].
Evidence summary
The current evidence consists primarily of in vitro studies, animal models (rats/mice), and reviews. There is limited human clinical data, with one pretest-posttest control study on dandruff shampoo.
PubMed sources
1.PMID: 33967304 (2021) — Extraction methods of butterfly pea (Clitoria ternatea) flower and biological activities of its phytochemicals. · Journal of food science and technology
2.PMID: 34975979 (2021) — Anthocyanins From Clitoria ternatea Flower: Biosynthesis, Extraction, Stability, Antioxidant Activity, and Applications. · Frontiers in plant science
3.PMID: 39280272 (2024) — Anti-dandruff effects of butterfly pea flowers (Clitoria ternatea)-based shampoo: A pretest-posttest control study. · Narra J
4.PMID: 37299340 (2023) — A Systematic Review of Butterfly Pea Flower (Clitoria ternatea L.): Extraction and Application as a Food Freshness pH-Indicator for Polymer-Based Intelligent Packaging. · Polymers
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Assessment of skin safety and anti-pollution activity of Clitoria ternatea L. (butterfly pea) flower extract.
· Journal of ethnopharmacology
6.PMID: 38328419 (2024) — Topical antifungal keratitis therapeutic potential of Clitoria ternatea Linn. flower extract: phytochemical profiling, in silico modelling, and in vitro biological activity assessment. · Frontiers in microbiology
7.PMID: 34996311 (2023) — Multivariate Analysis of Butterfly Pea (Clitoria ternatea L.) Genotypes With Potentially Healthy Nutraceuticals and Uses. · Journal of dietary supplements
8.PMID: 31191573 (2019) — Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine. · Frontiers in plant science
9.PMID: 37273557 (2023) — A natural blue colorant from butterfly pea (Clitoria ternatea) petals for traditional rice cooking. · Journal of food science and technology
10.PMID: 35812712 (2022) — Antibiofilm properties of Clitoria ternatea flower anthocyanin-rich fraction towards Pseudomonas aeruginosa. · Access microbiology
11.PMID: 37343678 (2023) — Bio-enhanced fraction from Clitoria ternatea root extract ameliorates cognitive functions and in vivo hippocampal neuroplasticity in chronic cerebral hypoperfusion rat model. · Ageing research reviews
12.PMID: 39598271 (2024) — Clitoria ternatea L. (Butterfly Pea) Flower Against Endometrial Pain: Integrating Preliminary In Vivo and In Vitro Experimentations Supported by Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation Studies. · Life (Basel, Switzerland)
13.PMID: 38442748 (2024) — Effects of clitorienolactones from Clitoria ternatea root on calcium channel mediating hippocampal long-term potentiation in rats induced chronic cerebral hypoperfusion. · Ageing research reviews
14.PMID: 39575021 (2024) — Neurohistopathological Alterations Induced by Clitoria Ternatea and Emblica Officinalis Extracts in Diabetic Male Wistar Rats. · Cureus
15.PMID: 42063109 (2026) — De novo transcriptome assembly of Clitoria ternatea flowers. · BMC research notes
16.PMID: 33801631 (2021) — Butterfly Pea Flower (Clitoria ternatea Linn.) Extract Ameliorates Cardiovascular Dysfunction and Oxidative Stress in Nitric Oxide-Deficient Hypertensive Rats. · Antioxidants (Basel, Switzerland)
17.PMID: 34622460 (2022) — Clitoria ternatea (Linn.) flower extract attenuates vascular dysfunction and cardiac hypertrophy via modulation of Ang II/AT1 R/TGF-β1 cascade in hypertensive rats. · Journal of the science of food and agriculture
18.PMID: 36050436 (2022) — Antioxidant, cytotoxic, and antibacterial activities of Clitoria ternatea flower extracts and anthocyanin-rich fraction. · Scientific reports
19.PMID: 28826781 (2018) — Clitoria ternatea flower petals: Effect on TNFR1 neutralization via downregulation of synovial matrix metalloproteases. · Journal of ethnopharmacology
20.PMID: 12895670 (2003) — Clitoria ternatea and the CNS. · Pharmacology, biochemistry, and behavior
21.PMID: 18926895 (2008) — The Ayurvedic medicine Clitoria ternatea--from traditional use to scientific assessment. · Journal of ethnopharmacology
22.PMID: 36422526 (2022) — Asian Pigeonwing Plants (Clitoria ternatea) Synergized Mesenchymal Stem Cells by Modulating the Inflammatory Response in Rats with Cisplatin-Induced Acute Kidney Injury. · Pharmaceuticals (Basel, Switzerland)
23.PMID: 37526116 (2023) — Anthocyanin-Rich Butterfly Pea Flower Extract Ameliorating Low-Grade Inflammation in a High-Fat-Diet and Lipopolysaccharide-Induced Mouse Model. · Journal of agricultural and food chemistry
24.PMID: 39335853 (2024) — Cookies Fortified with Clitoria ternatea Butterfly Pea Flower Petals: Antioxidant Capacity, Nutritional Composition, and Sensory Profile. · Foods (Basel, Switzerland)