PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Pretreatment with G. aparine (250 and 500 mg/kg) in rats significantly reduced liver necrosis and levels of ALT, AST, and bilirubin [PMID:36029804]
Dose-dependent increase in spleen weight, splenocyte proliferating activity, and NK cell activity in animal models [PMID:38474724]
Methanol extract showed cytotoxic and anti-proliferative effects in vitro [PMID:27085941]
Extracts demonstrated dose-dependent cytotoxicity and reduced cell metabolic activity in vitro [PMID:41493013]
Extracts showed significant inhibition against Staphylococcus aureus and Enterococcus strains with MIC values as low as 30 µg/mL [PMID:42075201]
Evidence summary
PubMed sources
- 1.PMID: 36029804 (2022) — Galium aparine L. protects against acetaminophen-induced hepatotoxicity in rats. · Chemico-biological interactions
- 2.PMID: 15574483 (2005) — Mechanical adaptations of cleavers (Galium aparine). · Annals of botany
- 3.PMID: 38474724 (2024) — Immuno-Enhancing Effects of Galium aparine L. in Cyclophosphamide-Induced Immunosuppressed Animal Models. · Nutrients
- 4.PMID: 21147808 (2011) — Always on the bright side: the climbing mechanism of Galium aparine. · Proceedings. Biological sciences
- 5.PMID: 32824103 (2020) — Immunomodulatory Activity and Phytochemical Profile of Infusions from Cleavers Herb.